HitPredict

Interactor 1: CHK2 (O96017)
Serine/threonine-protein kinase Chk2 (EC 2.7.11.1) (CHK2 checkpoint homolog) (Cds1 homolog) (Hucds1) (hCds1) (Checkpoint kinase 2)
Gene: CHEK2

Interactor 2: 2A5A (Q15172)
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform (PP2A B subunit isoform B'-alpha) (PP2A B subunit isoform B56-alpha) (PP2A B subunit isoform PR61-alpha) (PR61alpha) (PP2A B subunit isoform R5-alpha)
Gene: PPP2R5A

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.625

Property	Details
Experiments	37219487, 15380617
Identification Methods	unspecified method, two hybrid, pull down, phage display
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 543 Hs			1 486
+	Hs
		331288 CHK2_HUMAN (1-543): 1.66e-175: 508: 100.00		2A5D_HUMAN (12-477): 0: 712: 64.47
+	Hs
		331300 CHK2_HUMAN (1-543): 1.66e-175: 508: 100.00		2A5E_HUMAN (9-470): 0: 707: 78.36
+	Hs
		331293 CHK2_HUMAN (1-543): 1.66e-175: 508: 100.00		2A5B_HUMAN (2-465): 0: 705: 71.77
+	Hs
		331274 CHK2_HUMAN (1-543): 1.66e-175: 508: 100.00		2A5G_HUMAN (46-484): 0: 701: 68.32
+	Dm
		1213388 AKT1_DROME (7-536): 2.66e-146: 435: 23.50		Q9VB23_DROME (47-466): 0: 702: 77.91
+	Ce
		185206 AKT1_CAEEL (55-542): 5.71e-131: 393: 22.35		2A51_CAEEL (11-468): 0: 702: 67.25