HitPredict

Interactor 1: NSD2 (O96028)
Histone-lysine N-methyltransferase NSD2 (EC 2.1.1.357) (Multiple myeloma SET domain-containing protein) (MMSET) (Nuclear SET domain-containing protein 2) (Protein trithorax-5) (Wolf-Hirschhorn syndrome candidate 1 protein)
Gene: NSD2

Interactor 2: H31 (P68431)
Histone H3.1 (Histone H3/a) (Histone H3/b) (Histone H3/c) (Histone H3/d) (Histone H3/f) (Histone H3/h) (Histone H3/i) (Histone H3/j) (Histone H3/k) (Histone H3/l)
Gene: H3C1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.92	1.00	0.960

Property	Details
Experiments	25281560, 26912663, 34079125, 34271259, 36089195, 19481544, 25494638, 37150325
Identification Methods	proximity labelling technology, pull down, unspecified method, enzymatic study
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	AWS~Histone, Histone~PWWP, Histone~SET
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1365 Hs			1 136
+	Hs
		331823 NSD2_HUMAN (1-1365): 0: 980: 100.00		H31T_HUMAN (1-136): 1.27e-61: 187: 97.06
+	Hs
		331787 NSD2_HUMAN (1-1365): 0: 980: 100.00		H33_HUMAN (1-136): 2.73e-61: 186: 96.32
+	Hs
		331833 NSD2_HUMAN (1-1365): 0: 980: 100.00		H32_HUMAN (1-136): 6.5e-61: 185: 99.27
+	Hs
		331748 NSD2_HUMAN (1-1365): 0: 980: 100.00		CENPA_HUMAN (9-133): 5.62e-45: 145: 50.00
+	Hs
		935205 NSD3_HUMAN (116-1340): 0: 758: 45.19		H31_HUMAN (1-136): 2.8e-62: 188: 100.00
+	Hs
		1086307 NSD3_HUMAN (116-1340): 0: 758: 45.19		H31T_HUMAN (1-136): 1.27e-61: 187: 97.06
+	Hs
		952607 NSD3_HUMAN (116-1340): 0: 758: 45.19		H33_HUMAN (1-136): 2.73e-61: 186: 96.32
+	Hs
		1157224 NSD3_HUMAN (116-1340): 0: 758: 45.19		H3C_HUMAN (1-136): 5.49e-58: 177: 93.38
+	Hs
		828367 NSD3_HUMAN (116-1340): 0: 758: 45.19		CENPA_HUMAN (9-133): 5.62e-45: 145: 50.00
+	Hs
		203659 SUV91_HUMAN (830-1202): 5.28e-73: 251: 20.52		H31_HUMAN (1-136): 2.8e-62: 188: 100.00
+	Hs
		203664 SUV91_HUMAN (830-1202): 5.28e-73: 251: 20.52		H33_HUMAN (1-136): 2.73e-61: 186: 96.32
+	Hs
		935237 SUV92_HUMAN (826-1203): 4.69e-72: 249: 20.84		H31_HUMAN (1-136): 2.8e-62: 188: 100.00
+	Hs
		203722 SUV91_HUMAN (830-1202): 5.28e-73: 251: 20.52		H32_HUMAN (1-136): 6.5e-61: 185: 99.27
+	Dm
		356118 ASH1_DROME (991-1237): 8.56e-67: 251: 37.65		H3_DROME (1-136): 6.5e-61: 185: 99.27
+	Hs
		952627 SUV92_HUMAN (826-1203): 4.69e-72: 249: 20.84		H33_HUMAN (1-136): 2.73e-61: 186: 96.32
+	Hs
		203706 SUV91_HUMAN (830-1202): 5.28e-73: 251: 20.52		H37_HUMAN (1-136): 5.62e-59: 180: 97.06
+	Hs
		203711 SUV91_HUMAN (830-1202): 5.28e-73: 251: 20.52		H3C_HUMAN (1-136): 5.49e-58: 177: 93.38
+	Hs
		935276 ASH1L_HUMAN (924-1232): 1.1e-57: 222: 31.75		H31_HUMAN (1-136): 2.8e-62: 188: 100.00
+	Sc
		755791 SET1_YEAST (995-1203): 4.99e-62: 233: 31.11		H3_YEAST (1-136): 1.16e-55: 172: 88.97
+	Sc
		810349 SET2_YEAST (972-1208): 9.39e-61: 225: 35.12		H3_YEAST (1-136): 1.16e-55: 172: 88.97