HitPredict

Interactor 1: VAPB (O95292)
Vesicle-associated membrane protein-associated protein B/C (VAMP-B/VAMP-C) (VAMP-associated protein B/C) (VAP-B/VAP-C)
Gene: VAPB

Interactor 2: OSBL2 (Q9H1P3)
Oxysterol-binding protein-related protein 2 (ORP-2) (OSBP-related protein 2)
Gene: OSBPL2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.91	0.60	0.742

Property	Details
Experiments	25416956, 26186194, 28514442, 33961781, 24885147, 31515488, unassigned3799
Identification Methods	two hybrid, affinity chromatography technology, two hybrid array, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0030301 - cholesterol transport GO:0098978 - glutamatergic synapse
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 243 Hs			1 480
+	Hs
		1200615 Q53XM7_HUMAN (1-243): 2.24e-87: 260: 100.00		OSBL2_HUMAN (1-480): 0: 601: 100.00
+	Hs
		1431181 VAPA_HUMAN (1-243): 1.03e-79: 241: 62.30		OSBL2_HUMAN (1-480): 0: 601: 100.00
+	Hs
		333172 VAPB_HUMAN (1-243): 2.24e-87: 260: 100.00		OSBL1_HUMAN (3-480): 0: 574: 64.52
+	Hs
		1417433 VAPA_HUMAN (1-243): 1.03e-79: 241: 62.30		OSBL1_HUMAN (3-480): 0: 574: 64.52
+	Hs
		333127 VAPB_HUMAN (1-243): 2.24e-87: 260: 100.00		OSBP2_HUMAN (1-480): 1.83e-168: 500: 34.80
+	Hs
		333201 VAPB_HUMAN (1-243): 2.24e-87: 260: 100.00		OSBL3_HUMAN (2-470): 7.48e-166: 492: 36.95
+	Hs
		1380935 VAPA_HUMAN (1-243): 1.03e-79: 241: 62.30		OSBP2_HUMAN (1-480): 1.83e-168: 500: 34.80
+	Hs
		333179 VAPB_HUMAN (1-243): 2.24e-87: 260: 100.00		OSBL6_HUMAN (2-470): 4.08e-161: 481: 35.98
+	Hs
		332867 VAPB_HUMAN (1-243): 2.24e-87: 260: 100.00		OSBP1_HUMAN (2-480): 8.12e-162: 479: 35.96
+	Hs
		1433831 VAPA_HUMAN (1-243): 1.03e-79: 241: 62.30		OSBL3_HUMAN (2-470): 7.48e-166: 492: 36.95
+	Hs
		1419841 VAPA_HUMAN (1-243): 1.03e-79: 241: 62.30		OSBL6_HUMAN (2-470): 4.08e-161: 481: 35.98
+	Hs
		643401 VAPA_HUMAN (1-243): 1.03e-79: 241: 62.30		OSBP1_HUMAN (2-480): 8.12e-162: 479: 35.96
+	Hs
		1419831 VAPA_HUMAN (1-243): 1.03e-79: 241: 62.30		OSBL7_HUMAN (2-469): 1.66e-154: 461: 34.31
+	Hs
		333151 VAPB_HUMAN (1-243): 2.24e-87: 260: 100.00		OSBL9_HUMAN (2-471): 2.24e-131: 399: 20.75
+	Hs
		333170 VAPB_HUMAN (1-243): 2.24e-87: 260: 100.00		OSB10_HUMAN (24-470): 5.33e-125: 383: 20.21
+	Hs
		1403115 VAPA_HUMAN (1-243): 1.03e-79: 241: 62.30		OSBL9_HUMAN (2-471): 2.24e-131: 399: 20.75
+	Hs
		333178 VAPB_HUMAN (1-243): 2.24e-87: 260: 100.00		OSBL8_HUMAN (9-479): 6.94e-121: 376: 23.43
+	Hs
		333169 VAPB_HUMAN (1-243): 2.24e-87: 260: 100.00		OSB11_HUMAN (4-470): 1.06e-118: 366: 17.59
+	Hs
		1416746 VAPA_HUMAN (1-243): 1.03e-79: 241: 62.30		OSB10_HUMAN (24-470): 5.33e-125: 383: 20.21
+	Hs
		1416729 VAPA_HUMAN (1-243): 1.03e-79: 241: 62.30		OSB11_HUMAN (4-470): 1.06e-118: 366: 17.59