HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: LRSM1 (Q6UWE0)
E3 ubiquitin-protein ligase LRSAM1 (EC 2.3.2.27) (Leucine-rich repeat and sterile alpha motif-containing protein 1) (RING-type E3 ubiquitin transferase LRSAM1) (Tsg101-associated ligase) (hTAL)
Gene: LRSAM1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	15256501
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	GF_recep_IV~LRR_8, LRR_8~PK_Tyr_Ser-Thr
Common GO terms	GO:0005737 - cytoplasm GO:0016020 - membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1210 Hs			1 723
+	Hs
		338993 EGFR_HUMAN (1-1210): 0: 1241: 100.00		LRC40_HUMAN (30-251): 3.06e-16: 84.7: 18.60
+	Hs
		383931 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		LRCH3_HUMAN (11-433): 1.03e-53: 199: 19.38
+	Hs
		1071001 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		LRRC7_HUMAN (17-465): 1.12e-43: 172: 18.50
+	Hs
		383940 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		LRRC7_HUMAN (17-465): 1.12e-43: 172: 18.50
+	Hs
		601980 ERBB3_HUMAN (1-1210): 0: 1080: 40.95		LRRC7_HUMAN (17-465): 1.12e-43: 172: 18.50
+	Hs
		1071006 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		LRRC1_HUMAN (17-165): 2.67e-12: 71.6: 23.49
+	Hs
		383981 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		LRC40_HUMAN (30-251): 3.06e-16: 84.7: 18.60
+	At
		1352201 TMK3_ARATH (346-984): 2.89e-145: 464: 16.13		Y1723_ARATH (4-478): 3.21e-68: 245: 14.58
+	At
		795001 TMK1_ARATH (345-984): 1.18e-139: 449: 15.52		Y1723_ARATH (4-478): 3.21e-68: 245: 14.58
+	At
		84503 TMK3_ARATH (346-984): 2.89e-145: 464: 16.13		GSO1_ARATH (115-642): 2.85e-48: 186: 13.12
+	At
		84463 TMK1_ARATH (345-984): 1.18e-139: 449: 15.52		GSO1_ARATH (115-642): 2.85e-48: 186: 13.12
+	At
		1338064 TMK3_ARATH (346-984): 2.89e-145: 464: 16.13		RGI1_ARATH (224-646): 2.05e-31: 133: 10.78
+	At
		249715 TMK1_ARATH (345-984): 1.18e-139: 449: 15.52		BAME3_ARATH (173-612): 1.39e-34: 143: 14.32
+	At
		83709 Y5182_ARATH (429-1004): 1.84e-136: 439: 14.89		BAME3_ARATH (173-612): 1.39e-34: 143: 14.32
+	At
		221803 TMK3_ARATH (346-984): 2.89e-145: 464: 16.13		BAME1_ARATH (281-613): 7.82e-18: 90.3: 9.55
+	At
		1341092 TMK3_ARATH (346-984): 2.89e-145: 464: 16.13		BAME2_ARATH (343-674): 2.95e-14: 78.8: 12.05
+	At
		221760 TMK1_ARATH (345-984): 1.18e-139: 449: 15.52		BAME1_ARATH (281-613): 7.82e-18: 90.3: 9.55
+	At
		83702 Y5182_ARATH (429-1004): 1.84e-136: 439: 14.89		RGI3_ARATH (1-180): 1.69e-20: 99.2: 23.68
+	At
		83704 Y5182_ARATH (429-1004): 1.84e-136: 439: 14.89		Y4361_ARATH (302-666): 5.71e-19: 94.2: 9.24
+	At
		83707 Y5182_ARATH (429-1004): 1.84e-136: 439: 14.89		BAME1_ARATH (281-613): 7.82e-18: 90.3: 9.55