HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: MUC16 (Q8WXI7)
Mucin-16 (MUC-16) (Ovarian cancer-related tumor marker CA125) (CA-125) (Ovarian carcinoma antigen CA125)
Gene: MUC16

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	28065597
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1210 Hs			1 14507
+	Hs
		338878 EGFR_HUMAN (1-1210): 0: 1241: 100.00		MUC4_HUMAN (8258-12456): 3.06e-150: 535: 12.93
+	Hs
		1071005 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		MUC4_HUMAN (8258-12456): 3.06e-150: 535: 12.93
+	Hs
		383946 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		MUC4_HUMAN (8258-12456): 3.06e-150: 535: 12.93
+	Hs
		601984 ERBB3_HUMAN (1-1210): 0: 1080: 40.95		MUC4_HUMAN (8258-12456): 3.06e-150: 535: 12.93
+	Hs
		337733 EGFR_HUMAN (1-1210): 0: 1241: 100.00		FINC_HUMAN (6419-8055): 4.15e-90: 334: 8.55
+	Hs
		338965 EGFR_HUMAN (1-1210): 0: 1241: 100.00		TARA_HUMAN (5059-6767): 8.38e-24: 115: 7.76
+	Hs
		338874 EGFR_HUMAN (1-1210): 0: 1241: 100.00		MINT_HUMAN (2-1360): 3.26e-20: 104: 6.82
+	Hs
		337875 EGFR_HUMAN (1-1210): 0: 1241: 100.00		MUC1_HUMAN (53-1096): 1.41e-16: 91.9: 14.10
+	Hs
		338292 EGFR_HUMAN (1-1210): 0: 1241: 100.00		ANK2_HUMAN (10904-11798): 4.37e-13: 80.7: 11.91
+	Hs
		339147 EGFR_HUMAN (1-1210): 0: 1241: 100.00		SRRM2_HUMAN (10902-12233): 1.31e-12: 79.1: 10.16
+	Hs
		554307 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		MUC1_HUMAN (53-1096): 1.41e-16: 91.9: 14.10
+	Rn
		1143998 ERBB4_RAT (7-1199): 0: 1138: 49.38		PTPRZ_RAT (2653-3837): 1.81e-11: 75.3: 12.90
+	Hs
		383583 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		MUC1_HUMAN (53-1096): 1.41e-16: 91.9: 14.10
+	Hs
		554266 ERBB3_HUMAN (1-1210): 0: 1080: 40.95		MUC1_HUMAN (53-1096): 1.41e-16: 91.9: 14.10
+	Rn
		392799 INSR_RAT (579-1032): 2.5e-106: 367: 23.66		FINC_RAT (6419-8066): 1.31e-92: 343: 8.86
+	Rn
		544874 INSR_RAT (579-1032): 2.5e-106: 367: 23.66		Q63460_RAT (8003-12399): 3.56e-75: 286: 8.61
+	Hs
		311786 RET_HUMAN (420-1058): 5.61e-129: 425: 22.69		TACC2_HUMAN (3-2477): 1.03e-32: 145: 8.86
+	Hs
		665581 EPHB2_HUMAN (642-1067): 4.6e-119: 397: 28.76		ANK2_HUMAN (10904-11798): 4.37e-13: 80.7: 11.91
+	Mm
		975153 EPHA4_MOUSE (660-1016): 1.38e-120: 399: 31.52		NCOR2_MOUSE (10-1461): 1.41e-10: 72.2: 9.00
+	Mm
		222869 ACK1_MOUSE (691-967): 2.4e-53: 206: 38.87		ANK2_MOUSE (6-1177): 3.86e-11: 74.1: 13.33