HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: CNKR2 (Q8WXI2)
Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR 2) (CNK homolog protein 2) (CNK2)
Gene: CNKSR2

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.752

Property	Details
Experiments	27956147
Identification Methods	two hybrid, affinity chromatography technology, ubiquitin reconstruction, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	PH~PK_Tyr_Ser-Thr, PK_Tyr_Ser-Thr~SAM_1
Common GO terms	GO:0005737 - cytoplasm GO:0005886 - plasma membrane GO:0019901 - protein kinase binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1210 Hs			1 1034
+	Hs
		338350 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTN13_HUMAN (46-953): 1.05e-82: 297: 13.20
+	Hs
		338585 EGFR_HUMAN (1-1210): 0: 1241: 100.00		MPRIP_HUMAN (353-1025): 2.87e-63: 235: 13.90
+	Hs
		338819 EGFR_HUMAN (1-1210): 0: 1241: 100.00		DOC10_HUMAN (517-1031): 1.45e-59: 226: 13.63
+	Hs
		338561 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PKHA7_HUMAN (446-940): 1.89e-46: 183: 15.17
+	Hs
		338998 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PKHA5_HUMAN (446-918): 2.94e-45: 179: 15.29
+	Hs
		269508 EGFR_HUMAN (1-1210): 0: 1241: 100.00		SKAP2_HUMAN (477-736): 4.79e-43: 162: 16.11
+	Hs
		339151 EGFR_HUMAN (1-1210): 0: 1241: 100.00		GAB2_HUMAN (569-922): 4.27e-38: 154: 15.39
+	Mm
		1142641 ERBB4_MOUSE (7-1199): 0: 1146: 49.53		MAGI2_MOUSE (220-436): 8e-45: 178: 19.39
+	Hs
		1070980 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		MAGI2_HUMAN (220-575): 1.82e-42: 171: 15.12
+	Hs
		384030 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		GAB2_HUMAN (569-922): 4.27e-38: 154: 15.39
+	Hs
		434182 RET_HUMAN (420-1058): 5.61e-129: 425: 22.69		PTN13_HUMAN (46-953): 1.05e-82: 297: 13.20
+	Hs
		872638 EPHA4_HUMAN (660-1016): 3.35e-120: 398: 31.52		PTN13_HUMAN (46-953): 1.05e-82: 297: 13.20
+	Hs
		665589 EPHB2_HUMAN (642-1067): 4.6e-119: 397: 28.76		PTN13_HUMAN (46-953): 1.05e-82: 297: 13.20
+	Hs
		1020163 EPHA7_HUMAN (653-1072): 5.04e-118: 392: 27.23		PTN13_HUMAN (46-953): 1.05e-82: 297: 13.20
+	Hs
		665228 EPHA2_HUMAN (665-1016): 5.77e-117: 389: 32.79		PTN13_HUMAN (46-953): 1.05e-82: 297: 13.20
+	Hs
		665393 EPHA3_HUMAN (654-981): 7.78e-111: 372: 34.51		PTN13_HUMAN (46-953): 1.05e-82: 297: 13.20
+	Hs
		665271 EPHA2_HUMAN (665-1016): 5.77e-117: 389: 32.79		MPRIP_HUMAN (353-1025): 2.87e-63: 235: 13.90
+	Hs
		665661 EPHB2_HUMAN (642-1067): 4.6e-119: 397: 28.76		PKHA5_HUMAN (446-918): 2.94e-45: 179: 15.29
+	Hs
		1072602 EPHA7_HUMAN (653-1072): 5.04e-118: 392: 27.23		PKHA5_HUMAN (446-918): 2.94e-45: 179: 15.29
+	Hs
		872669 EPHA4_HUMAN (660-1016): 3.35e-120: 398: 31.52		MAGI2_HUMAN (220-575): 1.82e-42: 171: 15.12