HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: HSH2D (Q96JZ2)
Hematopoietic SH2 domain-containing protein (Hematopoietic SH2 protein) (Adaptor in lymphocytes of unknown function X)
Gene: HSH2D

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	22973453
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0007165 - signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1210 Hs			1 352
+	Mm
		403432 EGFR_MOUSE (1-1210): 0: 1258: 90.35		SRC_MOUSE (2-207): 3.48e-36: 139: 17.37
+	Hs
		337821 EGFR_HUMAN (1-1210): 0: 1241: 100.00		FGR_HUMAN (2-207): 1.19e-39: 148: 18.64
+	Mm
		964559 EGFR_MOUSE (1-1210): 0: 1258: 90.35		GRB2_MOUSE (14-150): 5.37e-35: 129: 24.66
+	Hs
		337789 EGFR_HUMAN (1-1210): 0: 1241: 100.00		YES_HUMAN (2-181): 3.84e-38: 144: 17.07
+	Rn
		1351588 Q9QX70_RAT (1-1210): 0: 1241: 90.34		SRC_RAT (2-207): 1.99e-36: 139: 17.37
+	Hs
		337850 EGFR_HUMAN (1-1210): 0: 1241: 100.00		SRC_HUMAN (2-207): 1.8e-36: 139: 17.37
+	Hs
		337769 EGFR_HUMAN (1-1210): 0: 1241: 100.00		LCK_HUMAN (2-207): 1.04e-35: 137: 19.57
+	Hs
		337804 EGFR_HUMAN (1-1210): 0: 1241: 100.00		HCK_HUMAN (15-207): 1.82e-35: 137: 17.97
+	Hs
		275158 EGFR_HUMAN (1-1210): 0: 1241: 100.00		GRAP2_HUMAN (3-162): 2.51e-36: 135: 23.21
+	Hs
		338251 EGFR_HUMAN (1-1210): 0: 1241: 100.00		GRB2_HUMAN (14-150): 1.34e-34: 127: 24.66
+	Hs
		338406 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTK6_HUMAN (30-149): 1.47e-32: 127: 28.46
+	Rn
		924998 Q9QX70_RAT (1-1210): 0: 1241: 90.34		GRB2_RAT (14-150): 1.34e-34: 127: 24.66
+	Hs
		337883 EGFR_HUMAN (1-1210): 0: 1241: 100.00		NCK1_HUMAN (1-121): 6.52e-31: 122: 28.46
+	Hs
		338546 EGFR_HUMAN (1-1210): 0: 1241: 100.00		SHE_HUMAN (33-128): 1.67e-25: 108: 25.00
+	Hs
		337886 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PLCG2_HUMAN (6-159): 1.15e-24: 107: 17.65
+	Hs
		337912 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PLCG1_HUMAN (4-147): 2.82e-24: 106: 21.25
+	Hs
		338084 EGFR_HUMAN (1-1210): 0: 1241: 100.00		FRK_HUMAN (24-136): 6.6e-23: 101: 28.80
+	Hs
		208970 EGFR_HUMAN (1-1210): 0: 1241: 100.00		NCK2_HUMAN (13-121): 6.71e-23: 100: 29.20
+	Hs
		338093 EGFR_HUMAN (1-1210): 0: 1241: 100.00		KSYK_HUMAN (33-142): 8.99e-18: 86.4: 27.59
+	Hs
		338092 EGFR_HUMAN (1-1210): 0: 1241: 100.00		ZAP70_HUMAN (33-139): 9.19e-17: 83.3: 29.20