HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: NED4L (Q96PU5)
E3 ubiquitin-protein ligase NEDD4-like (EC 2.3.2.26) (EC 2.3.2.36) (HECT-type E3 ubiquitin transferase NED4L) (NEDD4.2) (Nedd4-2)
Gene: NEDD4L

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	33762435
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1210 Hs			1 975
+	Hs
		601981 ERBB3_HUMAN (1-1210): 0: 1080: 40.95		NED4L_HUMAN (1-975): 0: 1033: 100.00
+	Hs
		338959 EGFR_HUMAN (1-1210): 0: 1241: 100.00		WWP1_HUMAN (1-972): 0: 781: 33.13
+	Hs
		338840 EGFR_HUMAN (1-1210): 0: 1241: 100.00		ITCH_HUMAN (9-972): 0: 772: 33.16
+	Hs
		338105 EGFR_HUMAN (1-1210): 0: 1241: 100.00		NEDD4_HUMAN (94-975): 0: 724: 49.78
+	Hs
		1071010 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		WWP1_HUMAN (1-972): 0: 781: 33.13
+	Hs
		1070998 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		ITCH_HUMAN (9-972): 0: 772: 33.16
+	Hs
		808132 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		NEDD4_HUMAN (94-975): 0: 724: 49.78
+	Hs
		601974 ERBB3_HUMAN (1-1210): 0: 1080: 40.95		ITCH_HUMAN (9-972): 0: 772: 33.16
+	Hs
		601847 ERBB3_HUMAN (1-1210): 0: 1080: 40.95		NEDD4_HUMAN (94-975): 0: 724: 49.78
+	Hs
		338634 EGFR_HUMAN (1-1210): 0: 1241: 100.00		HUWE1_HUMAN (358-973): 3.88e-170: 554: 32.26
+	Hs
		339005 EGFR_HUMAN (1-1210): 0: 1241: 100.00		SMUF1_HUMAN (17-499): 1.65e-30: 131: 15.71
+	Hs
		338999 EGFR_HUMAN (1-1210): 0: 1241: 100.00		SMUF2_HUMAN (21-324): 2e-29: 127: 22.56
+	Hs
		339072 EGFR_HUMAN (1-1210): 0: 1241: 100.00		HECW2_HUMAN (200-564): 1.39e-10: 67.7: 12.84
+	Hs
		992601 ACK1_HUMAN (691-967): 4.54e-56: 214: 39.58		NED4L_HUMAN (1-975): 0: 1033: 100.00
+	Hs
		383984 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		SMUF2_HUMAN (21-324): 2e-29: 127: 22.56
+	Hs
		434157 RET_HUMAN (420-1058): 5.61e-129: 425: 22.69		NEDD4_HUMAN (94-975): 0: 724: 49.78
+	Hs
		808104 ACK1_HUMAN (691-967): 4.54e-56: 214: 39.58		NEDD4_HUMAN (94-975): 0: 724: 49.78
+	Hs
		125405 ACK1_HUMAN (691-967): 4.54e-56: 214: 39.58		WWP2_HUMAN (228-972): 0: 719: 37.80
+	Hs
		992607 ACK1_HUMAN (691-967): 4.54e-56: 214: 39.58		SMUF1_HUMAN (17-499): 1.65e-30: 131: 15.71
+	Hs
		992589 ACK1_HUMAN (691-967): 4.54e-56: 214: 39.58		HECW1_HUMAN (144-528): 1.92e-09: 64.2: 13.73