HitPredict

Interactor 1: THRB (P00734)
Prothrombin (EC 3.4.21.5) (Coagulation factor II) [Cleaved into: Activation peptide fragment 1; Activation peptide fragment 2; Thrombin light chain; Thrombin heavy chain]
Gene: F2

Interactor 2: HEP2 (P05546)
Heparin cofactor 2 (Heparin cofactor II) (HC-II) (Protease inhibitor leuserpin-2) (HLS2) (Serpin D1)
Gene: SERPIND1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	12169660
Identification Methods	x-ray crystallography
Interaction Type	association

Property	Details
Interacting Pfam domains	Serpin~Trypsin
Common GO terms	GO:0005576 - extracellular region GO:0005615 - extracellular space GO:0005788 - endoplasmic reticulum lumen GO:0007596 - blood coagulation GO:0008201 - heparin binding and 1 others more... GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 622 Hs			1 499
+	Mm
		581130 THRB_MOUSE (1-621): 0: 594: 80.90		SPA3C_MOUSE (125-499): 5.98e-161: 464: 31.66
+	Hs
		341138 THRB_HUMAN (1-622): 0: 611: 100.00		SPB6_HUMAN (123-496): 1.69e-150: 436: 29.95
+	Hs
		341117 THRB_HUMAN (1-622): 0: 611: 100.00		ANT3_HUMAN (102-496): 2.22e-145: 426: 30.39
+	Hs
		341126 THRB_HUMAN (1-622): 0: 611: 100.00		IPSP_HUMAN (132-496): 1.36e-145: 425: 28.65
+	Hs
		397654 HGFA_HUMAN (75-618): 1.92e-100: 321: 24.87		IPSP_HUMAN (132-496): 1.36e-145: 425: 28.65
+	Hs
		371455 FA11_HUMAN (89-619): 3.95e-100: 319: 23.16		IPSP_HUMAN (132-496): 1.36e-145: 425: 28.65
+	Hs
		371463 KLKB1_HUMAN (88-620): 2.03e-96: 310: 23.35		IPSP_HUMAN (132-496): 1.36e-145: 425: 28.65
+	Hs
		341545 TPA_HUMAN (129-618): 6.02e-86: 280: 21.44		SPB6_HUMAN (123-496): 1.69e-150: 436: 29.95
+	Hs
		341525 TPA_HUMAN (129-618): 6.02e-86: 280: 21.44		PAI2_HUMAN (123-496): 1e-149: 435: 28.61
+	Mm
		430527 Q9Z1R9_MOUSE (356-620): 3.63e-87: 273: 33.59		A1AT1_MOUSE (118-497): 2.95e-150: 437: 28.46
+	Hs
		341527 TPA_HUMAN (129-618): 6.02e-86: 280: 21.44		IPSP_HUMAN (132-496): 1.36e-145: 425: 28.65
+	Hs
		428671 TRY1_HUMAN (357-621): 3.34e-88: 275: 32.08		SPB8_HUMAN (123-496): 1.45e-146: 426: 30.39
+	Hs
		341564 TPA_HUMAN (129-618): 6.02e-86: 280: 21.44		ZPI_HUMAN (124-497): 1.05e-135: 401: 31.30
+	Hs
		714770 TRY3_HUMAN (357-621): 2.45e-82: 262: 32.08		SPB12_HUMAN (123-496): 2.47e-134: 396: 28.57
+	Hs
		344172 CTRL_HUMAN (363-617): 5.8e-36: 137: 36.72		A1AT_HUMAN (95-498): 4.47e-153: 444: 27.59
+	Hs
		341268 FA9_HUMAN (10-193): 2.91e-32: 131: 26.74		ANT3_HUMAN (102-496): 2.22e-145: 426: 30.39
+	Hs
		375826 PROC_HUMAN (22-166): 8.79e-31: 127: 27.33		IPSP_HUMAN (132-496): 1.36e-145: 425: 28.65
+	Hs
		341478 UROK_HUMAN (53-262): 5.01e-19: 91.8: 17.76		PAI2_HUMAN (123-496): 1e-149: 435: 28.61
+	Hs
		1304624 ST14_HUMAN (234-617): 5.31e-100: 325: 27.64		NEUS_HUMAN (131-496): 1.11e-47: 171: 29.13
+	Hs
		341558 TPA_HUMAN (129-618): 6.02e-86: 280: 21.44		NEUS_HUMAN (131-496): 1.11e-47: 171: 29.13