HitPredict

Interactor 1: MYC (P01106)
Myc proto-oncogene protein (Class E basic helix-loop-helix protein 39) (bHLHe39) (Proto-oncogene c-Myc) (Transcription factor p64)
Gene: MYC

Interactor 2: RB (P06400)
Retinoblastoma-associated protein (p105-Rb) (p110-RB1) (pRb) (Rb) (pp110)
Gene: RB1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.77	0.60	0.680

The method score is based on:

Property	Details
Experiments	29467282, 30415952, 28205554, 7838535
Identification Methods	affinity chromatography technology, proximity labelling technology, fluorescent resonance energy transfer, two hybrid
Interaction Type	physical association, direct interaction

The annotation score is based on:

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000082 - G1/S transition of mitotic cell cycle GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0000785 - chromatin GO:0005634 - nucleus GO:0005654 - nucleoplasm and 5 others more... GO:0006338 - chromatin remodeling GO:0045944 - positive regulation of transcription by RNA polymerase II GO:0051276 - chromosome organization GO:0071466 - cellular response to xenobiotic stimulus GO:0140297 - DNA-binding transcription factor binding
Homologous interactions	2

Homologous interactions

Color coding for hit scores

	1	454
Hs

1	928

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024