HitPredict

Interactor 1: PLAK (P14923)
Junction plakoglobin (Catenin gamma) (Desmoplakin III) (Desmoplakin-3)
Gene: JUP

Interactor 2: FBXW7 (Q969H0)
F-box/WD repeat-containing protein 7 (Archipelago homolog) (hAgo) (F-box and WD-40 domain-containing protein 7) (F-box protein FBX30) (SEL-10) (hCdc4)
Gene: FBXW7

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	29408378, 33658012
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 745 Hs			1 707
+	Hs
		717264 CTNB1_HUMAN (1-731): 1.58e-173: 519: 67.38		FBXW7_HUMAN (1-707): 0: 571: 100.00
+	Hs
		239187 CTND1_HUMAN (203-728): 3.14e-90: 305: 16.25		FBXW7_HUMAN (1-707): 0: 571: 100.00
+	Mm
		970222 PLAK_MOUSE (1-745): 0: 553: 98.39		AHI1_MOUSE (119-704): 3.18e-91: 308: 17.70
+	Hs
		131484 IMA4_HUMAN (228-670): 5.34e-64: 224: 15.79		FBXW7_HUMAN (1-707): 0: 571: 100.00
+	Hs
		717329 CTNB1_HUMAN (1-731): 1.58e-173: 519: 67.38		TBL1R_HUMAN (251-570): 8.42e-66: 228: 18.58
+	Hs
		542260 PLAK_HUMAN (1-745): 0: 551: 100.00		WDR5_HUMAN (570-706): 2.64e-27: 115: 23.02
+	Hs
		716939 CTNB1_HUMAN (1-731): 1.58e-173: 519: 67.38		WDR5_HUMAN (570-706): 2.64e-27: 115: 23.02
+	Hs
		542482 PLAK_HUMAN (1-745): 0: 551: 100.00		FBW1A_HUMAN (614-705): 2.9e-12: 72: 26.09
+	Hs
		717419 CTNB1_HUMAN (1-731): 1.58e-173: 519: 67.38		FBXW2_HUMAN (574-692): 2.05e-17: 87.3: 26.89
+	Hs
		717449 CTNB1_HUMAN (1-731): 1.58e-173: 519: 67.38		FBW1A_HUMAN (614-705): 2.9e-12: 72: 26.09
+	Xl
		1193353 Q7ZX35_XENLA (1-740): 2.45e-173: 518: 67.51		TRCB_XENLA (614-705): 2.17e-12: 72: 26.09
+	Hs
		717413 CTNB1_HUMAN (1-731): 1.58e-173: 519: 67.38		FBW1B_HUMAN (614-705): 7.05e-12: 70.5: 25.00
+	Mm
		970129 CTNB1_MOUSE (1-731): 2.79e-173: 518: 67.38		FBW1A_MOUSE (614-705): 1.6e-11: 69.7: 26.09
+	Dm
		578711 ARM_DROME (2-730): 6.94e-161: 488: 60.33		Q9VDE3_DROME (607-705): 1.89e-12: 72.4: 22.00
+	Hs
		239105 CTND1_HUMAN (203-728): 3.14e-90: 305: 16.25		WDR5_HUMAN (570-706): 2.64e-27: 115: 23.02
+	Hs
		239228 CTND1_HUMAN (203-728): 3.14e-90: 305: 16.25		FBW1A_HUMAN (614-705): 2.9e-12: 72: 26.09
+	Ce
		1000138 BAR1_CAEEL (120-658): 1.54e-85: 289: 24.27		LIN23_CAEEL (614-705): 1.75e-10: 66.2: 22.83
+	Hs
		853759 IMA5_HUMAN (231-685): 6.58e-61: 215: 15.06		FBW1A_HUMAN (614-705): 2.9e-12: 72: 26.09
+	Hs
		853750 IMA5_HUMAN (231-685): 6.58e-61: 215: 15.06		FBW1B_HUMAN (614-705): 7.05e-12: 70.5: 25.00
+	Hs
		853512 IMA1_HUMAN (270-664): 6.19e-48: 179: 14.32		FBW1B_HUMAN (614-705): 7.05e-12: 70.5: 25.00