HitPredict

Interactor 1: MYC (P01106)
Myc proto-oncogene protein (Class E basic helix-loop-helix protein 39) (bHLHe39) (Proto-oncogene c-Myc) (Transcription factor p64)
Gene: MYC

Interactor 2: ENPL (P14625)
Endoplasmin (94 kDa glucose-regulated protein) (GRP-94) (Heat shock protein 90 kDa beta member 1) (Heat shock protein family C member 4) (Tumor rejection antigen 1) (gp96 homolog)
Gene: HSP90B1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.640

Property	Details
Experiments	29467282, 35013218, 36424410
Identification Methods	affinity chromatography technology, proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0006974 - DNA damage response GO:0032991 - protein-containing complex GO:0043066 - negative regulation of apoptotic process
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 454 Hs			1 803
+	Hs
		345729 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		HS90B_HUMAN (75-783): 0: 997: 46.54
+	Hs
		345717 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		HS90A_HUMAN (60-783): 0: 990: 45.34
+	Hs
		378975 MYCN_HUMAN (12-451): 9.39e-59: 201: 33.40		ENPL_HUMAN (1-803): 0: 1073: 100.00
+	Hs
		378924 MYCN_HUMAN (12-451): 9.39e-59: 201: 33.40		HS90B_HUMAN (75-783): 0: 997: 46.54
+	Hs
		378917 MYCN_HUMAN (12-451): 9.39e-59: 201: 33.40		HS90A_HUMAN (60-783): 0: 990: 45.34
+	Hs
		437954 SRBP1_HUMAN (95-453): 2.54e-33: 135: 16.19		HS90B_HUMAN (75-783): 0: 997: 46.54
+	Hs
		431605 SRBP1_HUMAN (95-453): 2.54e-33: 135: 16.19		HS90A_HUMAN (60-783): 0: 990: 45.34
+	Hs
		438044 MAX_HUMAN (354-454): 1.39e-24: 101: 32.67		HS90B_HUMAN (75-783): 0: 997: 46.54
+	Hs
		431713 MAX_HUMAN (354-454): 1.39e-24: 101: 32.67		HS90A_HUMAN (60-783): 0: 990: 45.34
+	Sc
		367108 HMS1_YEAST (171-438): 1.88e-28: 118: 14.77		HSP82_YEAST (72-783): 0: 867: 47.17