HitPredict

Interactor 1: MYC (P01106)
Myc proto-oncogene protein (Class E basic helix-loop-helix protein 39) (bHLHe39) (Proto-oncogene c-Myc) (Transcription factor p64)
Gene: MYC

Interactor 2: ITF2 (P15884)
Transcription factor 4 (TCF-4) (Class B basic helix-loop-helix protein 19) (bHLHb19) (Immunoglobulin transcription factor 2) (ITF-2) (SL3-3 enhancer factor 2) (SEF-2)
Gene: TCF4

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

The method score is based on:

Property	Details
Experiments	35013218, 25659031
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association

The annotation score is based on:

Property	Details
Interacting Pfam domains	HLH~HLH, HLH~Myc-LZ
Common GO terms	GO:0000785 - chromatin GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific GO:0001228 - DNA-binding transcription activator activity, RNA polymerase II-specific GO:0003677 - DNA binding and 5 others more... GO:0005634 - nucleus GO:0006357 - regulation of transcription by RNA polymerase II GO:0045893 - positive regulation of DNA-templated transcription GO:0045944 - positive regulation of transcription by RNA polymerase II GO:0070888 - E-box binding
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1	454
Hs

1	667

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024