Protein: EXOS7
Exosome complex component RRP42 (Exosome component 7) (Ribosomal RNA-processing protein 42) (p8)

Gene: EXOS7, EXOSC7
Organism: Homo sapiens
Interactions: 126
UniProt ID: Q15024

Gene Ontology (top 5):
GO:0000175 - 3'-5'-RNA exonuclease activity
GO:0000176 - nuclear exosome (RNase complex)
GO:0000177 - cytoplasmic exosome (RNase complex)
GO:0000178 - exosome (RNase complex)
GO:0000467 - exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1137671

EXOS4
Exosome complex component RRP41

10

19

Small-scale

0.977

High

1118279

EXOS2
Exosome complex component RRP4

9

20

Small-scale

0.973

High

1137689

EXOS1
Exosome complex component CSL4

8

20

Small-scale

0.972

High

1054464

EXOS9
Exosome complex component RRP45

7

18

Small-scale

0.963

High

1137624

EXOS6
Exosome complex component MTR3

7

18

Small-scale

0.961

High

1137675

EXOS3
Exosome complex component RRP40

6

12

Small-scale

0.949

High

1137674

EXOS5
Exosome complex component RRP46

5

19

High-throughput

0.932

High

1137646

DI3L1
DIS3-like exonuclease 1

5

19

Small-scale

0.930

High

1137652

EXOS8
Exosome complex component RRP43

5

17

High-throughput

0.923

High

1032167

EXOSX
Exosome complex component 10

8

12

Small-scale

0.748

High

1137691

RBM7
RNA-binding protein 7

6

8

High-throughput

0.734

High

1137660

MPH6
M-phase phosphoprotein 6

5

7

Small-scale

0.716

High

1137690

HBS1L
HBS1-like protein

4

4

Small-scale

0.696

High

838723

MTREX
Exosome RNA helicase MTR4

4

15

High-throughput

0.694

High

1137629

ZCHC8
Zinc finger CCHC domain-containing protein 8

4

3

High-throughput

0.694

High

1137688

RRP44
Exosome complex exonuclease RRP44

1

19

Small-scale

0.691

High

244701

ZC3H1
Zinc finger C3H1 domain-containing protein

3

5

High-throughput

0.667

High

1119055

C1D
Nuclear nucleic acid-binding protein C1D

3

3

High-throughput

0.667

High

1137632

UBP30
Ubiquitin carboxyl-terminal hydrolase 30

3

6

High-throughput

0.667

High

588732

RFA2
Replication protein A 32 kDa subunit

3

4

High-throughput

0.642

High

1137649

IP6K1
Inositol hexakisphosphate kinase 1

3

0

High-throughput

0.639

High

976895

ERR3
Estrogen-related receptor gamma

2

8

High-throughput

0.606

High

695495

RFA1
Replication protein A 70 kDa DNA-binding subunit

2

2

High-throughput

0.584

High

1137630

GGYF2
GRB10-interacting GYF protein 2

2

3

High-throughput

0.584

High

957600

UBE2K
Ubiquitin-conjugating enzyme E2 K

2

0

High-throughput

0.580

High

396138

ESR1
Estrogen receptor

2

8

High-throughput

0.571

High

624063

E2AK2
Interferon-induced, double-stranded RNA-activated protein kinase

1

2

High-throughput

0.536

High

833115

MNDA
Myeloid cell nuclear differentiation antigen

1

5

High-throughput

0.536

High

854064

KI67
Proliferation marker protein Ki-67

1

2

High-throughput

0.536

High

969869

RS16
Small ribosomal subunit protein uS9

1

2

High-throughput

0.536

High

992760

RACK1
Small ribosomal subunit protein RACK1

1

5

High-throughput

0.536

High

1109738

HDAC1
Histone deacetylase 1

1

1

High-throughput

0.536

High

1137637

LYRIC
Protein LYRIC

1

1

High-throughput

0.536

High

1137648

PSPC1
Paraspeckle component 1

1

5

High-throughput

0.536

High

1137664

AICDA
Single-stranded DNA cytosine deaminase

1

3

Small-scale

0.536

High

1137687

DRG1
Developmentally-regulated GTP-binding protein 1

1

3

High-throughput

0.536

High

724476

GDIA
Rab GDP dissociation inhibitor alpha

1

0

High-throughput

0.513

High

1065838

MZT1
Mitotic-spindle organizing protein 1

1

0

High-throughput

0.513

High

1137642

RM50
Large ribosomal subunit protein mL50

1

0

High-throughput

0.513

High

1137661

TSNAX
Translin-associated protein X

1

0

High-throughput

0.513

High

305840

DXO
Decapping and exoribonuclease protein

1

1

High-throughput

0.508

High

951680

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

1

High-throughput

0.501

High

1137640

PARP8
Protein mono-ADP-ribosyltransferase PARP8

1

1

High-throughput

0.489

High

223053

PRC1
Protein regulator of cytokinesis 1

1

1

High-throughput

0.481

High

321534

PRP6
Pre-mRNA-processing factor 6

1

5

High-throughput

0.481

High

1110989

SNW1
SNW domain-containing protein 1

1

1

High-throughput

0.481

High

1137621

DPYL2
Dihydropyrimidinase-related protein 2

1

3

High-throughput

0.481

High

1137623

PRC2B
Protein PRRC2B

1

2

High-throughput

0.481

High

1137625

KIF24
Kinesin-like protein KIF24

1

1

High-throughput

0.481

High

1137636

RALYL
RNA-binding Raly-like protein

1

3

High-throughput

0.481

High

1137653

ESS2
Splicing factor ESS-2 homolog

1

1

High-throughput

0.481

High

1137657

EHMT2
Histone-lysine N-methyltransferase EHMT2

1

1

High-throughput

0.481

High

1137667

UNKL
Putative E3 ubiquitin-protein ligase UNKL

1

2

High-throughput

0.481

High

1137678

RBM22
Pre-mRNA-splicing factor RBM22

1

3

High-throughput

0.481

High

1137682

TFP11
Tuftelin-interacting protein 11

1

1

High-throughput

0.481

High

422122

A4
Amyloid-beta precursor protein

1

0

High-throughput

0.480

High

129096

MEN1
Menin

1

3

High-throughput

0.479

High

218196

TGON2
Trans-Golgi network integral membrane protein 2

1

1

High-throughput

0.479

High

252068

IF4E2
Eukaryotic translation initiation factor 4E type 2

1

3

High-throughput

0.479

High

272191

OBSL1
Obscurin-like protein 1

1

2

High-throughput

0.479

High

315598

RECQ4
ATP-dependent DNA helicase Q4

1

4

High-throughput

0.479

High

335129

ARI2
E3 ubiquitin-protein ligase ARIH2

1

3

High-throughput

0.479

High

345840

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

7

High-throughput

0.479

High

372066

MYC
Myc proto-oncogene protein

1

3

High-throughput

0.479

High

406196

MYCN
N-myc proto-oncogene protein

1

3

High-throughput

0.479

High

413857

P53
Cellular tumor antigen p53

1

2

High-throughput

0.479

High

472749

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

8

High-throughput

0.479

High

537189

HSP7C
Heat shock cognate 71 kDa protein

1

1

High-throughput

0.479

High

768230

RFA3
Replication protein A 14 kDa subunit

1

2

High-throughput

0.479

High

872346

SOX2
Transcription factor SOX-2

1

1

High-throughput

0.479

High

881774

DHYS
Deoxyhypusine synthase

1

1

High-throughput

0.479

High

914946

THOP1
Thimet oligopeptidase

1

3

High-throughput

0.479

High

970524

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

3

High-throughput

0.479

High

1092131

NFX1
Transcriptional repressor NF-X1

1

3

High-throughput

0.479

High

1137619

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

4

High-throughput

0.479

High

1137622

IF16
Gamma-interferon-inducible protein 16

1

5

High-throughput

0.479

High

1137626

A16L1
Autophagy-related protein 16-1

1

7

High-throughput

0.479

High

1137634

ZCCHV
Zinc finger CCCH-type antiviral protein 1

1

1

Small-scale

0.479

High

1137638

ZCH18
Zinc finger CCCH domain-containing protein 18

1

5

High-throughput

0.479

High

1137639

LRC47
Leucine-rich repeat-containing protein 47

1

2

High-throughput

0.479

High

1137643

SIR6
NAD-dependent protein deacylase sirtuin-6

1

2

High-throughput

0.479

High

1137644

BICD2
Protein bicaudal D homolog 2

1

2

High-throughput

0.479

High

1137645

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

3

High-throughput

0.479

High

1137650

ESR2
Estrogen receptor beta

1

8

High-throughput

0.479

High

1137655

DDRGK
DDRGK domain-containing protein 1

1

3

High-throughput

0.479

High

1137656

RSRC1
Serine/Arginine-related protein 53

1

2

High-throughput

0.479

High

1137672

BRD7
Bromodomain-containing protein 7

1

2

High-throughput

0.479

High

1137676

ANLN
Anillin

1

3

High-throughput

0.479

High

1137680

UBP36
Ubiquitin carboxyl-terminal hydrolase 36

1

4

High-throughput

0.479

High

1137683

ZRAN1
Ubiquitin thioesterase ZRANB1

1

4

High-throughput

0.479

High

1137686

FZR1
Fizzy-related protein homolog

1

7

High-throughput

0.479

High

130471

SPT5H
Transcription elongation factor SPT5

1

0

High-throughput

0.460

High

474686

VIME
Vimentin

1

0

High-throughput

0.460

High

570890

MIF
Macrophage migration inhibitory factor

1

0

High-throughput

0.460

High

859610

RL21
Large ribosomal subunit protein eL21

1

0

High-throughput

0.460

High

1137620

K1H1
Keratin, type I cuticular Ha1

1

0

High-throughput

0.460

High

1137627

SNR48
U11/U12 small nuclear ribonucleoprotein 48 kDa protein

1

0

High-throughput

0.460

High

1137633

LARP4
La-related protein 4

1

0

High-throughput

0.460

High

1137651

RBPMS
RNA-binding protein with multiple splicing

1

0

High-throughput

0.460

High

1137654

THOC1
THO complex subunit 1

1

0

High-throughput

0.460

High

1137658

DMRTB
Doublesex- and mab-3-related transcription factor B1

1

0

High-throughput

0.460

High

1137663

MMTA2
Multiple myeloma tumor-associated protein 2

1

0

High-throughput

0.460

High

1137677

4ET
Eukaryotic translation initiation factor 4E transporter

1

0

High-throughput

0.460

High

1137679

TAP26
Thyroid transcription factor 1-associated protein 26

1

0

High-throughput

0.460

High

1137662

VRK1
Serine/threonine-protein kinase VRK1

1

0

High-throughput

0.458

High

1137669

NMRL1
NmrA-like family domain-containing protein 1

1

0

High-throughput

0.458

High

1137673

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

0

High-throughput

0.458

High

1112430

MTMR3
Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR3

1

1

Small-scale

0.457

High

1137635

UB2Q1
Ubiquitin-conjugating enzyme E2 Q1

1

1

High-throughput

0.457

High

1137647

UB2Q2
Ubiquitin-conjugating enzyme E2 Q2

1

1

High-throughput

0.457

High

429915

JUN
Transcription factor Jun

1

3

High-throughput

0.445

High

1137628

PKHA7
Pleckstrin homology domain-containing family A member 7

1

8

High-throughput

0.445

High

1137665

COMD4
COMM domain-containing protein 4

1

1

High-throughput

0.445

High

1137668

LN28A
Protein lin-28 homolog A

1

5

High-throughput

0.445

High

1137670

ALG13
UDP-N-acetylglucosamine transferase subunit ALG13

1

1

High-throughput

0.439

High

317571

SLIT2
Slit homolog 2 protein

1

2

High-throughput

0.437

High

908607

LUM
Lumican

1

2

High-throughput

0.437

High

1137631

TRI67
Tripartite motif-containing protein 67

1

4

High-throughput

0.437

High

1137641

FBXL6
F-box/LRR-repeat protein 6

1

1

High-throughput

0.437

High

1137666

PKHA4
Pleckstrin homology domain-containing family A member 4

1

5

High-throughput

0.437

High

1137681

HECW2
E3 ubiquitin-protein ligase HECW2

1

3

High-throughput

0.437

High

1137685

HECD1
E3 ubiquitin-protein ligase HECTD1

1

8

High-throughput

0.437

High

1137659

NUDC1
NudC domain-containing protein 1

1

0

High-throughput

0.426

High

608272

EGLN
Endoglin

1

0

High-throughput

0.279

Low

1137684

HOOK1
Protein Hook homolog 1

1

0

High-throughput

0.251

Low

62526

S35F4
Solute carrier family 35 member F4

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025