HitPredict

Interactor 1: MYC (P01106)
Myc proto-oncogene protein (Class E basic helix-loop-helix protein 39) (bHLHe39) (Proto-oncogene c-Myc) (Transcription factor p64)
Gene: MYC

Interactor 2: 1433B (P31946)
14-3-3 protein beta/alpha (Protein 1054) (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein beta/alpha, N-terminally processed]
Gene: YWHAB

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.78	0.60	0.686

Property	Details
Experiments	29467282, 35013218, 36424410, 17314511
Identification Methods	affinity chromatography technology, proximity labelling technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 454 Hs			1 246
+	Hs
		346416 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		1433E_HUMAN (3-243): 4.39e-144: 405: 65.43
+	Hs
		346464 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		1433Z_HUMAN (3-244): 1.49e-141: 398: 87.60
+	Hs
		345981 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		1433T_HUMAN (3-244): 3.24e-127: 361: 81.82
+	Hs
		346406 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		1433G_HUMAN (3-246): 1.91e-109: 317: 75.40
+	Hs
		346051 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		1433S_HUMAN (3-239): 3.38e-100: 293: 68.62
+	Hs
		379210 MYCN_HUMAN (12-451): 9.39e-59: 201: 33.40		1433E_HUMAN (3-243): 4.39e-144: 405: 65.43
+	Hs
		379060 MYCN_HUMAN (12-451): 9.39e-59: 201: 33.40		1433B_HUMAN (1-246): 3.48e-144: 404: 100.00
+	Hs
		379253 MYCN_HUMAN (12-451): 9.39e-59: 201: 33.40		1433Z_HUMAN (3-244): 1.49e-141: 398: 87.60
+	Hs
		910039 MLXIP_HUMAN (9-446): 1.64e-52: 191: 13.83		1433E_HUMAN (3-243): 4.39e-144: 405: 65.43
+	Hs
		683723 MLXIP_HUMAN (9-446): 1.64e-52: 191: 13.83		1433B_HUMAN (1-246): 3.48e-144: 404: 100.00
+	Hs
		927544 MLXIP_HUMAN (9-446): 1.64e-52: 191: 13.83		1433Z_HUMAN (3-244): 1.49e-141: 398: 87.60
+	Hs
		379040 MYCN_HUMAN (12-451): 9.39e-59: 201: 33.40		1433T_HUMAN (3-244): 3.24e-127: 361: 81.82
+	Hs
		297821 K0754_HUMAN (47-360): 3.79e-40: 156: 12.62		1433E_HUMAN (3-243): 4.39e-144: 405: 65.43
+	Hs
		297815 K0754_HUMAN (47-360): 3.79e-40: 156: 12.62		1433B_HUMAN (1-246): 3.48e-144: 404: 100.00
+	Hs
		297824 K0754_HUMAN (47-360): 3.79e-40: 156: 12.62		1433Z_HUMAN (3-244): 1.49e-141: 398: 87.60
+	Hs
		647289 MLXIP_HUMAN (9-446): 1.64e-52: 191: 13.83		1433T_HUMAN (3-244): 3.24e-127: 361: 81.82
+	Hs
		252907 MITF_HUMAN (155-450): 1.47e-29: 123: 14.47		1433B_HUMAN (1-246): 3.48e-144: 404: 100.00
+	Hs
		379202 MYCN_HUMAN (12-451): 9.39e-59: 201: 33.40		1433G_HUMAN (3-246): 1.91e-109: 317: 75.40
+	Hs
		905126 MLXIP_HUMAN (9-446): 1.64e-52: 191: 13.83		1433G_HUMAN (3-246): 1.91e-109: 317: 75.40
+	Hs
		982513 MLXIP_HUMAN (9-446): 1.64e-52: 191: 13.83		1433F_HUMAN (4-244): 2.7e-107: 311: 75.51