HitPredict

Interactor 1: MYC (P01106)
Myc proto-oncogene protein (Class E basic helix-loop-helix protein 39) (bHLHe39) (Proto-oncogene c-Myc) (Transcription factor p64)
Gene: MYC

Interactor 2: PPIA (P62937)
Peptidyl-prolyl cis-trans isomerase A (PPIase A) (EC 5.2.1.8) (Cyclophilin A) (Cyclosporin A-binding protein) (Rotamase A) [Cleaved into: Peptidyl-prolyl cis-trans isomerase A, N-terminally processed]
Gene: PPIA

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	29467282, 36424410
Identification Methods	affinity chromatography technology, proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0032873 - negative regulation of stress-activated MAPK cascade GO:0032991 - protein-containing complex
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 454 Hs			1 165
+	Hs
		348237 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		PPIE_HUMAN (2-163): 2.08e-88: 262: 67.28
+	Hs
		345940 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		PPIB_HUMAN (2-165): 9.46e-88: 257: 63.64
+	Hs
		203487 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		PPIH_HUMAN (2-164): 1.38e-84: 247: 53.85
+	Hs
		346241 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		RBP2_HUMAN (3-164): 1.87e-73: 240: 66.67
+	Hs
		379247 MYCN_HUMAN (12-451): 9.39e-59: 201: 33.40		PPIA_HUMAN (1-165): 2.77e-91: 264: 100.00
+	Hs
		380019 MYCN_HUMAN (12-451): 9.39e-59: 201: 33.40		PPIE_HUMAN (2-163): 2.08e-88: 262: 67.28
+	Hs
		379021 MYCN_HUMAN (12-451): 9.39e-59: 201: 33.40		PPIB_HUMAN (2-165): 9.46e-88: 257: 63.64
+	Hs
		203491 MYCN_HUMAN (12-451): 9.39e-59: 201: 33.40		PPIH_HUMAN (2-164): 1.38e-84: 247: 53.85