Protein: SEPT8
Septin-8

Gene: SEPT8, SEPTIN8
Organism: Homo sapiens
Interactions: 77
UniProt ID: Q92599

Gene Ontology (top 5):
GO:0003924 - GTPase activity
GO:0005525 - GTP binding
GO:0005940 - septin ring
GO:0008104 - intracellular protein localization
GO:0015630 - microtubule cytoskeleton

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1156399

SEPT7
Septin-7

8

20

High-throughput

0.967

High

1365294

SEP10
Septin-10

6

20

High-throughput

0.947

High

1365285

SEPT5
Septin-5

5

19

Small-scale

0.929

High

1136990

SEPT2
Septin-2

5

19

High-throughput

0.927

High

1365296

SEPT3
Neuronal-specific septin-3

5

19

High-throughput

0.925

High

1121191

SEPT6
Septin-6

4

20

High-throughput

0.903

High

1315274

SEP12
Septin-12

3

20

High-throughput

0.861

High

1361600

SEPT1
Septin-1

3

19

High-throughput

0.861

High

1365293

SEP11
Septin-11

3

19

High-throughput

0.855

High

1365297

SEPT9
Septin-9

2

19

Small-scale

0.789

High

1256417

SEP14
Septin-14

1

19

High-throughput

0.691

High

1365289

BORG4
Cdc42 effector protein 4

3

15

High-throughput

0.667

High

890671

RGS3
Regulator of G-protein signaling 3

3

9

High-throughput

0.662

High

210502

SEPT4
Septin-4

1

20

Small-scale

0.590

High

1365280

SEPT8
Septin-8

1

19

Small-scale

0.590

High

242459

PRKN
E3 ubiquitin-protein ligase parkin

2

11

High-throughput

0.584

High

914689

RM12
Large ribosomal subunit protein bL12m

2

9

High-throughput

0.574

High

530147

TAU
Microtubule-associated protein tau

2

15

High-throughput

0.571

High

422752

A4
Amyloid-beta precursor protein

1

5

High-throughput

0.515

High

1365286

SH3G1
Endophilin-A2

1

3

High-throughput

0.508

High

1365287

SH3G3
Endophilin-A3

1

4

High-throughput

0.508

High

322112

CDK14
Cyclin-dependent kinase 14

1

5

Small-scale

0.504

High

407674

S100B
Protein S100-B

1

0

High-throughput

0.493

High

158275

COPE
Coatomer subunit epsilon

1

4

High-throughput

0.489

High

773587

COPB2
Coatomer subunit beta'

1

9

High-throughput

0.489

High

1365284

ACAP3
Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3

1

10

High-throughput

0.489

High

1365288

CPVL
Probable serine carboxypeptidase CPVL

1

4

High-throughput

0.489

High

374104

RASN
GTPase NRas

1

20

High-throughput

0.479

High

374821

RASH
GTPase HRas

1

19

High-throughput

0.479

High

375790

RASK
GTPase KRas

1

20

High-throughput

0.479

High

439809

INSR
Insulin receptor

1

20

High-throughput

0.479

High

464023

RET
Proto-oncogene tyrosine-protein kinase receptor Ret

1

20

High-throughput

0.479

High

465595

IGF1R
Insulin-like growth factor 1 receptor

1

20

High-throughput

0.479

High

710872

EPHB2
Ephrin type-B receptor 2

1

14

High-throughput

0.479

High

955435

CDC42
Cell division control protein 42 homolog

1

13

High-throughput

0.479

High

1034307

ROR2
Tyrosine-protein kinase transmembrane receptor ROR2

1

20

High-throughput

0.479

High

369717

A2MG
Alpha-2-macroglobulin

1

1

High-throughput

0.464

High

1365298

KMT2B
Histone-lysine N-methyltransferase 2B

1

5

High-throughput

0.464

High

396624

ESR1
Estrogen receptor

1

12

Small-scale

0.457

High

720287

UFO
Tyrosine-protein kinase receptor UFO

1

20

High-throughput

0.457

High

1209459

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

5

High-throughput

0.445

High

1227175

A16L1
Autophagy-related protein 16-1

1

3

High-throughput

0.445

High

1028833

SPTB2
Spectrin beta chain, non-erythrocytic 1

1

2

Small-scale

0.439

High

106376

APRIO
Alternative prion protein

1

8

High-throughput

0.437

High

173150

XPO1
Exportin-1

1

12

High-throughput

0.437

High

181809

EPHB6
Ephrin type-B receptor 6

1

14

High-throughput

0.437

High

302594

RNF8
E3 ubiquitin-protein ligase RNF8

1

5

Small-scale

0.437

High

346134

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

6

High-throughput

0.437

High

363651

EGFR
Epidermal growth factor receptor

1

17

High-throughput

0.437

High

410973

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

19

High-throughput

0.437

High

484195

PGFRB
Platelet-derived growth factor receptor beta

1

18

High-throughput

0.437

High

540597

LAMP1
Lysosome-associated membrane glycoprotein 1

1

4

High-throughput

0.437

High

541616

FGFR1
Fibroblast growth factor receptor 1

1

20

High-throughput

0.437

High

582906

EZRI
Ezrin

1

3

High-throughput

0.437

High

648611

FGFR4
Fibroblast growth factor receptor 4

1

20

High-throughput

0.437

High

696085

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

5

High-throughput

0.437

High

761278

RYK
Tyrosine-protein kinase RYK

1

20

High-throughput

0.437

High

768782

RFA3
Replication protein A 14 kDa subunit

1

5

High-throughput

0.437

High

872589

SOX2
Transcription factor SOX-2

1

2

High-throughput

0.437

High

1067553

EP300
Histone acetyltransferase p300

1

6

High-throughput

0.437

High

1254872

TRI67
Tripartite motif-containing protein 67

1

14

High-throughput

0.437

High

1350391

BICD2
Protein bicaudal D homolog 2

1

7

High-throughput

0.437

High

1364481

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

4

High-throughput

0.437

High

1365281

SH3K1
SH3 domain-containing kinase-binding protein 1

1

7

High-throughput

0.437

High

1365283

LRCH3
DISP complex protein LRCH3

1

7

High-throughput

0.437

High

1365291

ANLN
Anillin

1

12

High-throughput

0.437

High

1365295

ZRAN1
Ubiquitin thioesterase ZRANB1

1

7

High-throughput

0.437

High

1365299

SRRM2
Serine/arginine repetitive matrix protein 2

1

4

High-throughput

0.437

High

653474

HEMH
Ferrochelatase, mitochondrial

1

2

High-throughput

0.407

High

1167091

WHAL1
Putative WASP homolog-associated protein with actin, membranes and microtubules-like protein 1

1

1

High-throughput

0.407

High

161830

RIOK3
Serine/threonine-protein kinase RIO3

1

0

High-throughput

0.279

Low

1365282

MUCL1
Mucin-like protein 1

1

0

High-throughput

0.279

Low

1365292

MBNL1
Muscleblind-like protein 1

1

0

High-throughput

0.279

Low

1234191

JADE1
Protein Jade-1

1

0

High-throughput

0.265

Low

1338155

PPHLN
Periphilin-1

1

0

High-throughput

0.265

Low

1365290

TPC
Mitochondrial thiamine pyrophosphate carrier

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025