HitPredict

Interactor 1: MYC (P01106)
Myc proto-oncogene protein (Class E basic helix-loop-helix protein 39) (bHLHe39) (Proto-oncogene c-Myc) (Transcription factor p64)
Gene: MYC

Interactor 2: AMRA1 (Q9C0C7)
Activating molecule in BECN1-regulated autophagy protein 1 (DDB1- and CUL4-associated factor 3)
Gene: AMBRA1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.60	0.60	0.601

Property	Details
Experiments	25438055, 29467282
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0006357 - regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 454 Hs			1 1298
+	Hs
		346404 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		WDR5_HUMAN (3-297): 2.47e-87: 289: 18.39
+	Hs
		347550 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		SNR40_HUMAN (45-329): 6.16e-55: 197: 11.75
+	Hs
		267729 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		TAF5L_HUMAN (57-304): 3.13e-36: 148: 15.14
+	Hs
		346159 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		LIS1_HUMAN (123-346): 3.66e-35: 141: 11.45
+	Hs
		379200 MYCN_HUMAN (12-451): 9.39e-59: 201: 33.40		WDR5_HUMAN (3-297): 2.47e-87: 289: 18.39
+	Hs
		347409 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		UTP15_HUMAN (27-201): 9.25e-21: 99.8: 16.85
+	Hs
		347517 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		FBXW7_HUMAN (164-329): 5.74e-18: 91.8: 9.58
+	Mm
		348444 MYC_MOUSE (1-454): 4.33e-119: 357: 89.01		FBXW7_MOUSE (164-329): 6.08e-18: 91.8: 9.58
+	Hs
		607803 USF1_HUMAN (175-453): 1.02e-39: 146: 18.40		WDR5_HUMAN (3-297): 2.47e-87: 289: 18.39
+	Hs
		903353 MGAP_HUMAN (151-449): 1.22e-27: 118: 17.71		WDR5_HUMAN (3-297): 2.47e-87: 289: 18.39
+	Hs
		379701 MYCN_HUMAN (12-451): 9.39e-59: 201: 33.40		SNR40_HUMAN (45-329): 6.16e-55: 197: 11.75
+	Mm
		659344 MAX_MOUSE (354-454): 3.52e-25: 102: 32.67		WDR5_MOUSE (3-297): 2.47e-87: 289: 18.39
+	Hs
		1218698 MGAP_HUMAN (151-449): 1.22e-27: 118: 17.71		SNR40_HUMAN (45-329): 6.16e-55: 197: 11.75
+	Hs
		267736 MYCL_HUMAN (29-449): 4.2e-42: 154: 30.11		TAF5L_HUMAN (57-304): 3.13e-36: 148: 15.14
+	Hs
		379688 MYCN_HUMAN (12-451): 9.39e-59: 201: 33.40		FBXW7_HUMAN (164-329): 5.74e-18: 91.8: 9.58
+	Hs
		267750 MAX_HUMAN (354-454): 1.39e-24: 101: 32.67		TAF5L_HUMAN (57-304): 3.13e-36: 148: 15.14
+	Mm
		1112323 SRBP2_MOUSE (124-446): 2.23e-37: 147: 13.60		FBXW7_MOUSE (164-329): 6.08e-18: 91.8: 9.58
+	Mm
		1257396 SRBP1_MOUSE (172-453): 4.45e-35: 140: 16.61		FBXW7_MOUSE (164-329): 6.08e-18: 91.8: 9.58
+	Hs
		738987 SRBP1_HUMAN (95-453): 2.54e-33: 135: 16.19		FBXW7_HUMAN (164-329): 5.74e-18: 91.8: 9.58
+	At
		189017 MYC2_ARATH (200-454): 1.78e-32: 132: 18.05		GBLPA_ARATH (1-123): 1.2e-16: 84.5: 20.13