HitPredict

Interactor 1: BAG3 (O95817)
BAG family molecular chaperone regulator 3 (BAG-3) (Bcl-2-associated athanogene 3) (Bcl-2-binding protein Bis) (Docking protein CAIR-1)
Gene: BAG3

Interactor 2: Q96IS6 (Q96IS6)
Heat shock cognate 71 kDa protein (EC 3.6.4.10) (Heat shock 70 kDa protein 8)
Gene: HSPA8

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.44	0.80	0.594

Property	Details
Experiments	25416956
Identification Methods	two hybrid prey pooling approach, two hybrid array, validated two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	BAG~HSP70
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 575 Hs			1 587
+	Hs
		347555 BAG3_HUMAN (1-575): 0: 809: 100.00		HS71L_HUMAN (1-587): 0: 872: 81.26
+	Hs
		347494 BAG3_HUMAN (1-575): 0: 809: 100.00		HSP7C_HUMAN (1-587): 0: 868: 100.00
+	Hs
		347515 BAG3_HUMAN (1-575): 0: 809: 100.00		HSP76_HUMAN (1-587): 0: 864: 76.49
+	Hs
		347739 BAG3_HUMAN (1-575): 0: 809: 100.00		Q53FC7_HUMAN (1-587): 0: 860: 75.98
+	Hs
		347489 BAG3_HUMAN (1-575): 0: 809: 100.00		HS71A_HUMAN (1-587): 0: 851: 83.48
+	Hs
		347599 BAG3_HUMAN (1-575): 0: 809: 100.00		HSP72_HUMAN (1-587): 0: 844: 84.21
+	Mm
		989288 BAG3_MOUSE (1-575): 0: 762: 83.31		HSP7C_MOUSE (1-587): 0: 867: 99.83
+	Mm
		609032 BAG3_MOUSE (1-575): 0: 762: 83.31		HS71B_MOUSE (1-587): 0: 861: 82.96
+	Mm
		609028 BAG4_MOUSE (381-499): 1.39e-37: 146: 43.70		HS71B_MOUSE (1-587): 0: 861: 82.96
+	Hs
		336630 BAG4_HUMAN (381-499): 3.46e-33: 134: 43.70		HS71L_HUMAN (1-587): 0: 872: 81.26
+	Hs
		336616 BAG4_HUMAN (381-499): 3.46e-33: 134: 43.70		HSP7C_HUMAN (1-587): 0: 868: 100.00
+	Hs
		336621 BAG4_HUMAN (381-499): 3.46e-33: 134: 43.70		HSP76_HUMAN (1-587): 0: 864: 76.49
+	Hs
		336682 BAG4_HUMAN (381-499): 3.46e-33: 134: 43.70		Q53FC7_HUMAN (1-587): 0: 860: 75.98
+	Hs
		336646 BAG4_HUMAN (381-499): 3.46e-33: 134: 43.70		HSP72_HUMAN (1-587): 0: 844: 84.21
+	Hs
		761536 BAG5_HUMAN (418-498): 3.24e-17: 86.4: 41.98		HS71L_HUMAN (1-587): 0: 872: 81.26
+	Hs
		538096 BAG5_HUMAN (418-498): 3.24e-17: 86.4: 41.98		HSP7C_HUMAN (1-587): 0: 868: 100.00
+	Dm
		538284 Q9VU81_DROME (398-498): 1.21e-26: 116: 32.11		HSP7D_DROME (1-553): 0: 838: 85.35
+	Dm
		68638 A8JNS4_DROME (398-498): 1.34e-26: 116: 32.11		HSP7D_DROME (1-553): 0: 838: 85.35
+	Hs
		600958 BAG5_HUMAN (418-498): 3.24e-17: 86.4: 41.98		HSP76_HUMAN (1-587): 0: 864: 76.49
+	Hs
		931157 BAG5_HUMAN (418-498): 3.24e-17: 86.4: 41.98		HSP72_HUMAN (1-587): 0: 844: 84.21