HitPredict

Interactor 1: M4K4 (O95819)
Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1) (HPK/GCK-like kinase HGK) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (Nck-interacting kinase)
Gene: MAP4K4

Interactor 2: RHOB (P62745)
Rho-related GTP-binding protein RhoB (Rho cDNA clone 6) (h6)
Gene: RHOB

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	34079125, 31871319
Identification Methods	proximity labelling technology, affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Pkinase~Ras
Common GO terms	GO:0005925 - focal adhesion
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1239 Hs			1 196
+	Hs
		348102 M4K4_HUMAN (1-1239): 0: 1238: 100.00		RAC1_HUMAN (1-196): 1.47e-79: 236: 55.10
+	Hs
		348048 M4K4_HUMAN (1-1239): 0: 1238: 100.00		RAC2_HUMAN (1-196): 4.54e-77: 230: 53.57
+	Hs
		348108 M4K4_HUMAN (1-1239): 0: 1238: 100.00		RHOG_HUMAN (1-196): 3.36e-76: 228: 51.53
+	Hs
		348087 M4K4_HUMAN (1-1239): 0: 1238: 100.00		RAC3_HUMAN (1-179): 5.41e-75: 225: 57.54
+	Hs
		126423 M4K4_HUMAN (1-1239): 0: 1238: 100.00		RHOD_HUMAN (7-182): 3.38e-66: 203: 53.98
+	Mm
		988877 TNIK_MOUSE (1-1239): 0: 1135: 62.25		RAC1_MOUSE (1-196): 1.47e-79: 236: 55.10
+	Hs
		988524 MINK1_HUMAN (1-1239): 0: 1130: 59.29		RAC1_HUMAN (1-196): 1.47e-79: 236: 55.10
+	Hs
		978160 MINK1_HUMAN (1-1239): 0: 1130: 59.29		RHOB_HUMAN (1-196): 8.92e-78: 232: 100.00
+	Hs
		581164 MINK1_HUMAN (1-1239): 0: 1130: 59.29		RAC2_HUMAN (1-196): 4.54e-77: 230: 53.57
+	Hs
		953560 MINK1_HUMAN (1-1239): 0: 1130: 59.29		RAC3_HUMAN (1-179): 5.41e-75: 225: 57.54
+	Hs
		978391 TNIK_HUMAN (1-1239): 0: 1115: 60.45		RHOB_HUMAN (1-196): 8.92e-78: 232: 100.00
+	Hs
		601371 MINK1_HUMAN (1-1239): 0: 1130: 59.29		RHOQ_HUMAN (2-195): 6.74e-68: 207: 51.74
+	Hs
		126695 MINK1_HUMAN (1-1239): 0: 1130: 59.29		RHOD_HUMAN (7-182): 3.38e-66: 203: 53.98
+	Hs
		988444 MRCKG_HUMAN (13-974): 4.84e-143: 473: 17.19		RAC1_HUMAN (1-196): 1.47e-79: 236: 55.10
+	Hs
		955289 MRCKG_HUMAN (13-974): 4.84e-143: 473: 17.19		CDC42_HUMAN (1-196): 7.26e-75: 225: 49.49
+	Dm
		828064 GEK_DROME (16-983): 5.99e-141: 469: 13.49		CDC42_DROME (1-196): 1.51e-74: 224: 49.49
+	Hs
		601331 MRCKG_HUMAN (13-974): 4.84e-143: 473: 17.19		RHOQ_HUMAN (2-195): 6.74e-68: 207: 51.74
+	Hs
		580880 MARK3_HUMAN (16-680): 1.75e-129: 417: 15.10		RAC2_HUMAN (1-196): 4.54e-77: 230: 53.57
+	Hs
		466114 MARK3_HUMAN (16-680): 1.75e-129: 417: 15.10		RHOC_HUMAN (1-196): 8.71e-76: 227: 83.16
+	Hs
		126466 MARK3_HUMAN (16-680): 1.75e-129: 417: 15.10		RHOD_HUMAN (7-182): 3.38e-66: 203: 53.98