HitPredict

Interactor 1: MYC (P01106)
Myc proto-oncogene protein (Class E basic helix-loop-helix protein 39) (bHLHe39) (Proto-oncogene c-Myc) (Transcription factor p64)
Gene: MYC

Interactor 2: CHIP (Q9UNE7)
E3 ubiquitin-protein ligase CHIP (EC 2.3.2.27) (Antigen NY-CO-7) (CLL-associated antigen KW-8) (Carboxy terminus of Hsp70-interacting protein) (RING-type E3 ubiquitin transferase CHIP) (STIP1 homology and U box-containing protein 1)
Gene: STUB1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.79	0.60	0.692

Property	Details
Experiments	22543587, 28128329, 31155734, 35013218
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000165 - MAPK cascade GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0071456 - cellular response to hypoxia
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 454 Hs			1 303
+	Hs
		347882 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		UN45A_HUMAN (15-161): 8.39e-42: 155: 29.30
+	Hs
		252936 MITF_HUMAN (155-450): 1.47e-29: 123: 14.47		CHIP_HUMAN (1-303): 3.8e-69: 218: 100.00
+	Hs
		585131 TFEB_HUMAN (180-450): 2.56e-28: 118: 14.59		CHIP_HUMAN (1-303): 3.8e-69: 218: 100.00
+	Hs
		898194 MAX_HUMAN (354-454): 1.39e-24: 101: 32.67		UN45A_HUMAN (15-161): 8.39e-42: 155: 29.30
+	Dm
		1366986 MYC_DROME (210-454): 3.25e-30: 126: 26.74		Q9VH81_DROME (4-246): 6.54e-32: 125: 16.87
+	Dm
		1366985 Q9W4Q7_DROME (358-449): 5.64e-19: 91.7: 29.03		Q9VH81_DROME (4-246): 6.54e-32: 125: 16.87
+	Mm
		1100610 PK1L3_MOUSE (37-365): 1.8e-10: 65.6: 12.25		WDTC1_MOUSE (21-272): 7.36e-30: 120: 19.22