Protein: M4K5
Mitogen-activated protein kinase kinase kinase kinase 5 (EC 2.7.11.1) (Kinase homologous to SPS1/STE20) (KHS) (MAPK/ERK kinase kinase kinase 5) (MEK kinase kinase 5) (MEKKK 5)

Gene: M4K5, MAP4K5
Organism: Homo sapiens
Interactions: 90
UniProt ID: Q9Y4K4

Gene Ontology (top 5):
GO:0004672 - protein kinase activity
GO:0004674 - protein serine/threonine kinase activity
GO:0005524 - ATP binding
GO:0005737 - cytoplasm
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1308767

M4K3
Mitogen-activated protein kinase kinase kinase kinase 3

4

17

High-throughput

0.896

High

988064

GRB2
Growth factor receptor-bound protein 2

10

20

Small-scale

0.754

High

364081

EGFR
Epidermal growth factor receptor

2

20

Small-scale

0.754

High

412875

NTRK1
High affinity nerve growth factor receptor

2

20

High-throughput

0.754

High

1462016

ALK
ALK tyrosine kinase receptor

2

20

High-throughput

0.754

High

473486

HCK
Tyrosine-protein kinase HCK

1

20

High-throughput

0.698

High

855821

CRK
Adapter molecule crk

4

20

Small-scale

0.691

High

855959

CRKL
Crk-like protein

3

20

Small-scale

0.664

High

1315170

ZN440
Zinc finger protein 440

1

5

High-throughput

0.625

High

473218

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

4

High-throughput

0.618

High

243391

PRKN
E3 ubiquitin-protein ligase parkin

1

18

High-throughput

0.618

High

341181

DIRA3
GTP-binding protein Di-Ras3

1

20

High-throughput

0.618

High

376140

RASK
GTPase KRas

1

20

High-throughput

0.618

High

440805

FYN
Tyrosine-protein kinase Fyn

1

20

High-throughput

0.618

High

463863

LYN
Tyrosine-protein kinase Lyn

1

20

High-throughput

0.618

High

541780

FGFR1
Fibroblast growth factor receptor 1

1

20

High-throughput

0.618

High

605863

KAPCA
cAMP-dependent protein kinase catalytic subunit alpha

1

17

High-throughput

0.618

High

710591

EPHA2
Ephrin type-A receptor 2

1

20

High-throughput

0.618

High

845874

MUC18
Cell surface glycoprotein MUC18

1

10

High-throughput

0.618

High

931919

EPHA5
Ephrin type-A receptor 5

1

20

High-throughput

0.618

High

976693

RB11A
Ras-related protein Rab-11A

1

7

High-throughput

0.618

High

978428

RHOB
Rho-related GTP-binding protein RhoB

1

20

High-throughput

0.618

High

988857

RAC1
Ras-related C3 botulinum toxin substrate 1

1

20

High-throughput

0.618

High

1004249

CXAR
Coxsackievirus and adenovirus receptor

1

5

High-throughput

0.618

High

1034388

ROR2
Tyrosine-protein kinase transmembrane receptor ROR2

1

20

High-throughput

0.618

High

1055113

TYRO3
Tyrosine-protein kinase receptor TYRO3

1

20

High-throughput

0.618

High

1087705

M4K2
Mitogen-activated protein kinase kinase kinase kinase 2

1

17

High-throughput

0.618

High

1108317

SQSTM
Sequestosome-1

1

11

High-throughput

0.618

High

1145195

RAB35
Ras-related protein Rab-35

1

16

High-throughput

0.618

High

1147471

EPHA7
Ephrin type-A receptor 7

1

20

High-throughput

0.618

High

1157121

NTRK3
NT-3 growth factor receptor

1

20

High-throughput

0.618

High

1158622

CDC37
Hsp90 co-chaperone Cdc37

1

11

High-throughput

0.618

High

1256250

TRI67
Tripartite motif-containing protein 67

1

20

High-throughput

0.618

High

1433020

DNJC5
DnaJ homolog subfamily C member 5

1

10

High-throughput

0.618

High

1434328

PKHA4
Pleckstrin homology domain-containing family A member 4

1

20

High-throughput

0.618

High

1332127

EIF1A
Probable RNA-binding protein EIF1AD

2

0

High-throughput

0.585

High

1491438

M4K5
Mitogen-activated protein kinase kinase kinase kinase 5

1

17

Small-scale

0.575

High

1124769

SRC8
Src substrate cortactin

1

20

High-throughput

0.561

High

1370497

CSN5
COP9 signalosome complex subunit 5

1

10

High-throughput

0.541

High

1099832

MD2L1
Mitotic spindle assembly checkpoint protein MAD2A

1

2

High-throughput

0.536

High

1293442

CARM1
Histone-arginine methyltransferase CARM1

1

3

High-throughput

0.536

High

1027879

HNRPU
Heterogeneous nuclear ribonucleoprotein U

1

7

High-throughput

0.515

High

572735

AK1A1
Aldo-keto reductase family 1 member A1

1

0

High-throughput

0.513

High

1139882

SETB1
Histone-lysine N-methyltransferase SETDB1

1

8

High-throughput

0.508

High

861857

NEDD4
E3 ubiquitin-protein ligase NEDD4

1

20

High-throughput

0.501

High

1439025

SMUF1
E3 ubiquitin-protein ligase SMURF1

1

20

Small-scale

0.501

High

528380

THIO
Thioredoxin

1

2

High-throughput

0.479

High

594152

NCK1
SH2/SH3 adapter protein NCK1

1

20

High-throughput

0.479

High

604288

CXA1
Gap junction alpha-1 protein

1

11

High-throughput

0.479

High

643161

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

6

High-throughput

0.479

High

643592

PIMT
Protein-L-isoaspartate(D-aspartate) O-methyltransferase

1

2

High-throughput

0.479

High

711442

SHC1
SHC-transforming protein 1

1

20

High-throughput

0.479

High

732435

PRDX2
Peroxiredoxin-2

1

6

High-throughput

0.479

High

880410

RL34
Large ribosomal subunit protein eL34

1

1

High-throughput

0.479

High

921589

PGTB2
Geranylgeranyl transferase type-2 subunit beta

1

1

High-throughput

0.479

High

967069

1433G
14-3-3 protein gamma

1

20

High-throughput

0.479

High

975340

ARF6
ADP-ribosylation factor 6

1

10

High-throughput

0.479

High

984600

RL30
Large ribosomal subunit protein eL30

1

3

High-throughput

0.479

High

985588

RL32
Large ribosomal subunit protein eL32

1

4

High-throughput

0.479

High

1041392

CAV1
Caveolin-1

1

10

High-throughput

0.479

High

1090993

TRAF2
TNF receptor-associated factor 2

1

20

Small-scale

0.479

High

1159918

OCLN
Occludin

1

6

High-throughput

0.479

High

1233611

LTOR1
Ragulator complex protein LAMTOR1

1

5

High-throughput

0.479

High

1246182

TRAF7
E3 ubiquitin-protein ligase TRAF7

1

18

High-throughput

0.479

High

1385105

PTER
N-acetyltaurine hydrolase

1

1

High-throughput

0.479

High

1404933

PARK7
Parkinson disease protein 7

1

1

High-throughput

0.479

High

1408386

SH3G1
Endophilin-A2

1

20

High-throughput

0.479

High

1437992

CYBP
Calcyclin-binding protein

1

3

High-throughput

0.479

High

1459441

ZRAN1
Ubiquitin thioesterase ZRANB1

1

11

High-throughput

0.479

High

1460652

DBNL
Drebrin-like protein

1

19

High-throughput

0.479

High

1491384

TCAF1
TRPM8 channel-associated factor 1

1

1

High-throughput

0.479

High

1491439

SNX9
Sorting nexin-9

1

6

High-throughput

0.479

High

596446

H12
Histone H1.2

1

4

High-throughput

0.470

High

693149

DPP4
Dipeptidyl peptidase 4

1

0

High-throughput

0.458

High

66699

RTL1
Retrotransposon-like protein 1

1

1

High-throughput

0.437

High

140040

RCAS1
Receptor-binding cancer antigen expressed on SiSo cells

1

3

High-throughput

0.437

High

373604

MYC
Myc proto-oncogene protein

1

16

High-throughput

0.437

High

590124

RFA2
Replication protein A 32 kDa subunit

1

10

High-throughput

0.437

High

696963

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

9

High-throughput

0.437

High

699290

CALX
Calnexin

1

1

High-throughput

0.437

High

769606

RFA3
Replication protein A 14 kDa subunit

1

7

High-throughput

0.437

High

1382018

CK052
Uncharacterized protein C11orf52

1

6

High-throughput

0.437

High

1435750

CH033
UPF0488 protein C8orf33

1

2

High-throughput

0.437

High

1403530

CDRTF
CMT1A duplicated region transcript 15 protein

3

0

High-throughput

0.347

High

480364

RU1C
U1 small nuclear ribonucleoprotein C

1

0

High-throughput

0.279

Low

65861

LR14B
Leucine-rich repeat-containing protein 14B

1

0

High-throughput

0.249

Low

553106

PIP
Prolactin-inducible protein

1

0

High-throughput

0.249

Low

963251

LYSC
Lysozyme C

1

0

High-throughput

0.249

Low

1445832

BPIA1
BPI fold-containing family A member 1

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025