HitPredict

Interactor 1: RASN (P01111)
GTPase NRas (EC 3.6.5.2) (Transforming protein N-Ras)
Gene: NRAS

Interactor 2: RGPS2 (Q86X27)
Ras-specific guanine nucleotide-releasing factor RalGPS2 (Ral GEF with PH domain and SH3-binding motif 2) (RalA exchange factor RalGPS2)
Gene: RALGPS2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	30194290
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PH~Ras, Ras~RasGEF
Common GO terms	GO:0005886 - plasma membrane GO:0007265 - Ras protein signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 189 Hs			1 583
+	Hs
		350308 RASK_HUMAN (16-189): 7.56e-85: 249: 85.71		RGPS2_HUMAN (1-583): 0: 643: 100.00
+	Hs
		350111 RASK_HUMAN (16-189): 7.56e-85: 249: 85.71		SOS1_HUMAN (18-469): 7.13e-103: 340: 19.83
+	Mm
		699619 RASK_MOUSE (1-189): 3.25e-85: 251: 87.90		RGL2_MOUSE (24-480): 2.79e-104: 333: 21.74
+	Ce
		612367 LET60_CAEEL (1-181): 1.39e-88: 259: 76.80		Q19770_CAEEL (4-481): 1.37e-100: 320: 17.73
+	Hs
		171533 RASK_HUMAN (16-189): 7.56e-85: 249: 85.71		RGL2_HUMAN (26-480): 5.4e-102: 327: 20.83
+	Hs
		348635 RASN_HUMAN (1-189): 9.9e-80: 236: 100.00		SOS1_HUMAN (18-469): 7.13e-103: 340: 19.83
+	Ce
		105960 LET60_CAEEL (1-181): 1.39e-88: 259: 76.80		RPGF_CAEEL (18-473): 5.95e-94: 316: 16.83
+	Hs
		350126 RASK_HUMAN (16-189): 7.56e-85: 249: 85.71		GNDS_HUMAN (9-458): 1.82e-99: 324: 19.27
+	Hs
		350385 RASK_HUMAN (16-189): 7.56e-85: 249: 85.71		RPGF6_HUMAN (18-462): 3.55e-96: 323: 15.79
+	Mm
		440302 RASN_MOUSE (1-189): 5.14e-80: 237: 98.41		RGL2_MOUSE (24-480): 2.79e-104: 333: 21.74
+	Hs
		171531 RASN_HUMAN (1-189): 9.9e-80: 236: 100.00		RGL2_HUMAN (26-480): 5.4e-102: 327: 20.83
+	Hs
		348818 RASN_HUMAN (1-189): 9.9e-80: 236: 100.00		RPGF6_HUMAN (18-462): 3.55e-96: 323: 15.79
+	Ce
		1089983 RAP1_CAEEL (1-189): 1.35e-78: 234: 52.11		Q19770_CAEEL (4-481): 1.37e-100: 320: 17.73
+	Hs
		348971 RASN_HUMAN (1-189): 9.9e-80: 236: 100.00		RGL1_HUMAN (16-462): 1.53e-97: 315: 20.42
+	Dm
		442998 RAS1_DROME (1-170): 2.87e-90: 263: 83.53		Q86BI2_DROME (43-442): 5.07e-87: 287: 20.14
+	Dm
		443004 RAS1_DROME (1-170): 2.87e-90: 263: 83.53		Q9GR11_DROME (43-442): 6.86e-87: 287: 20.14
+	Ce
		103461 LET60_CAEEL (1-181): 1.39e-88: 259: 76.80		G4SFM6_CAEEL (37-471): 1.61e-86: 288: 19.67
+	Hs
		156389 RASK_HUMAN (16-189): 7.56e-85: 249: 85.71		RGRF2_HUMAN (6-290): 4.32e-88: 298: 28.67
+	Ce
		612368 LET60_CAEEL (1-181): 1.39e-88: 259: 76.80		Q19852_CAEEL (37-471): 2.41e-86: 288: 19.67
+	Hs
		348697 RASN_HUMAN (1-189): 9.9e-80: 236: 100.00		RGL3_HUMAN (14-454): 1.13e-89: 293: 21.70