HitPredict

Interactor 1: RASH (P01112)
GTPase HRas (EC 3.6.5.2) (H-Ras-1) (Ha-Ras) (Transforming protein p21) (c-H-ras) (p21ras) [Cleaved into: GTPase HRas, N-terminally processed]
Gene: HRAS

Interactor 2: RAB5C (P51148)
Ras-related protein Rab-5C (EC 3.6.5.2) (L1880) (RAB5L)
Gene: RAB5C

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	30655611
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Ras~Ras
Common GO terms	GO:0003924 - GTPase activity GO:0003925 - G protein activity GO:0005525 - GTP binding GO:0005794 - Golgi apparatus GO:0005886 - plasma membrane and 2 others more... GO:0006897 - endocytosis GO:0019003 - GDP binding
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 189 Hs			1 216
+	Hs
		348601 RASN_HUMAN (1-188): 6.47e-88: 257: 85.64		RAB1A_HUMAN (12-214): 1.9e-93: 273: 41.18
+	Hs
		350037 RASK_HUMAN (1-188): 2.04e-84: 248: 86.24		RAB1A_HUMAN (12-214): 1.9e-93: 273: 41.18
+	Zm
		73944 B4FAE1_MAIZE (4-187): 6.22e-79: 235: 33.67		B4FAE1_MAIZE (14-215): 1.57e-95: 278: 41.38
+	Hs
		348682 RASN_HUMAN (1-188): 6.47e-88: 257: 85.64		RB11B_HUMAN (12-216): 8.62e-85: 252: 38.89
+	Hs
		350033 RASK_HUMAN (1-188): 2.04e-84: 248: 86.24		RB11A_HUMAN (12-216): 7.61e-88: 259: 39.25
+	Hs
		844470 RAB1A_HUMAN (4-186): 2.67e-75: 226: 31.28		RAB5C_HUMAN (1-216): 3.2e-94: 275: 100.00
+	Hs
		350197 RASK_HUMAN (1-188): 2.04e-84: 248: 86.24		RB11B_HUMAN (12-216): 8.62e-85: 252: 38.89
+	Hs
		918846 RAB1A_HUMAN (4-186): 2.67e-75: 226: 31.28		RAB1A_HUMAN (12-214): 1.9e-93: 273: 41.18
+	Hs
		844468 RB11A_HUMAN (4-178): 4.48e-74: 223: 33.90		RAB5C_HUMAN (1-216): 3.2e-94: 275: 100.00
+	Hs
		918944 RAB1A_HUMAN (4-186): 2.67e-75: 226: 31.28		RAB1B_HUMAN (14-214): 1.47e-90: 265: 40.30
+	Mm
		919000 RAB1A_MOUSE (4-186): 2.67e-75: 226: 31.28		RAB1B_MOUSE (14-214): 1.85e-90: 265: 40.30
+	Hs
		913992 RAB1A_HUMAN (4-186): 2.67e-75: 226: 31.28		RB11A_HUMAN (12-216): 7.61e-88: 259: 39.25
+	Hs
		913989 RB11A_HUMAN (4-178): 4.48e-74: 223: 33.90		RB11A_HUMAN (12-216): 7.61e-88: 259: 39.25
+	Hs
		918879 RAB1A_HUMAN (4-186): 2.67e-75: 226: 31.28		RB11B_HUMAN (12-216): 8.62e-85: 252: 38.89
+	Hs
		914093 RB11A_HUMAN (4-178): 4.48e-74: 223: 33.90		RB11B_HUMAN (12-216): 8.62e-85: 252: 38.89
+	Hs
		348506 RASN_HUMAN (1-188): 6.47e-88: 257: 85.64		RAB6A_HUMAN (16-213): 2.31e-51: 166: 40.59
+	Hs
		349871 RASK_HUMAN (1-188): 2.04e-84: 248: 86.24		RAB6A_HUMAN (16-213): 2.31e-51: 166: 40.59
+	Hs
		592649 RB11A_HUMAN (4-178): 4.48e-74: 223: 33.90		RAB6A_HUMAN (16-213): 2.31e-51: 166: 40.59