HitPredict

Interactor 1: H3 (P02299)
Histone H3
Gene: H3, His3;

Interactor 2: TRX (P20659)
Histone-lysine N-methyltransferase trithorax (EC 2.1.1.355) (Cysteine methyltransferase KMT2A) (EC 2.1.1.-) (Lysine N-methyltransferase 2A)
Gene: TRX

Species: Drosophila melanogaster

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.83	1.00	0.914

Property	Details
Experiments	12408863, 24235145, 24550119, 14730313, unassigned4
Identification Methods	enzymatic study, experimental interaction detection
Interaction Type	direct interaction, methylation reaction, physical association

Property	Details
Interacting Pfam domains	Histone~SET
Common GO terms	GO:0005700 - polytene chromosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 136 Dm			1 3726
+	Hs
		935276 H31_HUMAN (1-136): 1.98e-62: 189: 99.27		ASH1L_HUMAN (2461-3725): 4.44e-91: 336: 14.12
+	Hs
		935205 H31_HUMAN (1-136): 1.98e-62: 189: 99.27		NSD3_HUMAN (2864-3725): 8.77e-89: 324: 12.58
+	Hs
		935149 H31_HUMAN (1-136): 1.98e-62: 189: 99.27		RSF1_HUMAN (868-1391): 7.19e-83: 305: 14.36
+	Hs
		935368 H31_HUMAN (1-136): 1.98e-62: 189: 99.27		KMT2B_HUMAN (2757-3726): 6.75e-77: 289: 22.96
+	Hs
		256961 H31_HUMAN (1-136): 1.98e-62: 189: 99.27		KDM4A_HUMAN (1531-2006): 5.09e-79: 288: 12.53
+	Hs
		256973 H31T_HUMAN (1-136): 8.3e-62: 187: 96.32		KDM4A_HUMAN (1531-2006): 5.09e-79: 288: 12.53
+	Hs
		934804 H31_HUMAN (1-136): 1.98e-62: 189: 99.27		EZH2_HUMAN (3103-3709): 2.89e-80: 285: 13.71
+	Hs
		1079993 H31T_HUMAN (1-136): 8.3e-62: 187: 96.32		EZH2_HUMAN (3103-3709): 2.89e-80: 285: 13.71
+	Hs
		301134 H31_HUMAN (1-136): 1.98e-62: 189: 99.27		KDM4B_HUMAN (1519-2019): 5.66e-71: 264: 14.13
+	Hs
		935237 H31_HUMAN (1-136): 1.98e-62: 189: 99.27		SUV92_HUMAN (3405-3726): 1.09e-75: 261: 19.13
+	Hs
		203659 H31_HUMAN (1-136): 1.98e-62: 189: 99.27		SUV91_HUMAN (3415-3725): 1.22e-72: 252: 20.06
+	Hs
		331780 H31_HUMAN (1-136): 1.98e-62: 189: 99.27		NSD2_HUMAN (2898-3725): 1.12e-64: 247: 11.20
+	Hs
		331823 H31T_HUMAN (1-136): 8.3e-62: 187: 96.32		NSD2_HUMAN (2898-3725): 1.12e-64: 247: 11.20
+	Hs
		935374 H31_HUMAN (1-136): 1.98e-62: 189: 99.27		SET1B_HUMAN (3506-3726): 4.47e-62: 239: 33.47
+	Hs
		165661 H31_HUMAN (1-136): 1.98e-62: 189: 99.27		SET1A_HUMAN (3515-3726): 3.01e-60: 233: 40.00
+	Hs
		935004 H31_HUMAN (1-136): 1.98e-62: 189: 99.27		KMT2C_HUMAN (2429-3428): 9.35e-18: 93.9: 12.73
+	Hs
		152625 H31_HUMAN (1-136): 1.98e-62: 189: 99.27		KMT2D_HUMAN (1651-1850): 2.28e-17: 92.6: 21.85
+	Hs
		935129 H31_HUMAN (1-136): 1.98e-62: 189: 99.27		NSD1_HUMAN (3590-3725): 7.08e-17: 90.9: 39.13
+	Hs
		934681 H31_HUMAN (1-136): 1.98e-62: 189: 99.27		KMT2A_HUMAN (2215-3264): 1.02e-11: 74.1: 13.29
+	Hs
		975268 H31T_HUMAN (1-136): 8.3e-62: 187: 96.32		KMT2A_HUMAN (2215-3264): 1.02e-11: 74.1: 13.29