HitPredict

Interactor 1: O97102 (O97102)
Small ubiquitin-related modifier (SUMO)
Gene: Sumo

Interactor 2: Q7KUA4 (Q7KUA4)
SUMO-activating enzyme subunit
Gene: Uba2

Species: Drosophila melanogaster

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	1.00	0.768

Property	Details
Experiments	11884525, 10995744
Identification Methods	affinity chromatography technology, enzymatic study
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	Rad60-SLD~ThiF
Common GO terms	GO:0002225 - positive regulation of antimicrobial peptide production GO:0005634 - nucleus GO:0016925 - protein sumoylation GO:0045752 - positive regulation of Toll signaling pathway
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 90 Dm			1 700
+	Rn
		73329 SUMO3_RAT (1-88): 3.42e-37: 122: 69.57		B1WC32_RAT (4-665): 0: 614: 46.51
+	Hs
		939236 SUMO3_HUMAN (1-90): 5.79e-37: 121: 69.15		SAE2_HUMAN (4-665): 0: 596: 47.03
+	Hs
		964489 SUMO2_HUMAN (1-89): 1.32e-35: 117: 67.02		SAE2_HUMAN (4-665): 0: 596: 47.03
+	Hs
		107819 SUMO5_HUMAN (1-88): 3.7e-33: 111: 47.42		SAE2_HUMAN (4-665): 0: 596: 47.03
+	Hs
		991448 SUMO1_HUMAN (7-88): 2.33e-32: 109: 53.66		SAE2_HUMAN (4-665): 0: 596: 47.03
+	Sc
		912384 SMT3_YEAST (8-89): 2.97e-29: 101: 46.34		UBA2_YEAST (2-671): 0: 537: 30.59
+	Sp
		149269 PMT3_SCHPO (2-88): 5.02e-37: 122: 52.87		UBA2_SCHPO (11-620): 5.31e-172: 508: 34.12
+	Rn
		1216900 SUMO3_RAT (1-88): 3.42e-37: 122: 69.57		UBA1_RAT (8-151): 5.99e-29: 125: 25.69
+	Hs
		647526 SUMO2_HUMAN (1-89): 1.32e-35: 117: 67.02		UBA1_HUMAN (8-224): 5.7e-30: 129: 21.46
+	Dm
		356374 O97102_DROME (1-90): 3.07e-39: 127: 100.00		Q8T0L3_DROME (8-197): 6.18e-18: 90.6: 21.05