Protein: Q8T0L3
E1 ubiquitin-activating enzyme (EC 6.2.1.45) (Ubiquitin-activating enzyme E1)

Gene: Q8T0L3, Uba1
Organism: Drosophila melanogaster
Interactions: 208
UniProt ID: Q8T0L3

Gene Ontology (top 5):
GO:0000209 - protein polyubiquitination
GO:0000423 - mitophagy
GO:0004839 - ubiquitin activating enzyme activity
GO:0005524 - ATP binding
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

762720

UBE2N
Ubiquitin-conjugating enzyme E2 N

1

20

High-throughput

0.618

High

356374

O97102
Small ubiquitin-related modifier

1

16

High-throughput

0.575

High

1344410

Q8SYG3
E2 ubiquitin-conjugating enzyme

1

20

High-throughput

0.575

High

1345305

Q9VRL1
GEO06356p1

1

20

High-throughput

0.575

High

624351

CI
Transcriptional activator cubitus interruptus

1

0

High-throughput

0.518

High

1174332

RPR
Cell death protein rpr

1

0

High-throughput

0.518

High

1175579

GRIM
Cell death protein Grim

1

0

High-throughput

0.518

High

1345296

Q9VNB2
RE42193p

1

1

High-throughput

0.514

High

1345241

DDX41
ATP-dependent RNA helicase abstrakt

1

0

High-throughput

0.486

High

1345327

Q9VYK7
glutathione-specific gamma-glutamylcyclotransferase

1

0

High-throughput

0.486

High

118964

M9NFI9
Neurabin-1

1

3

High-throughput

0.484

High

68949

MBD56
Methyl-CpG-binding domain protein 5/6 homolog sba

1

1

High-throughput

0.479

High

198220

O18680
5-aminolevulinate synthase

1

1

High-throughput

0.464

High

1345314

PYRG
CTP synthase

1

0

High-throughput

0.458

High

1345321

S6KL
Serine/threonine-protein kinase S6KL

1

1

High-throughput

0.457

High

47772

A0AQH0
Proteasome subunit beta

1

2

High-throughput

0.445

High

57581

A1ZB71
Glutathione S transferase E6

1

1

High-throughput

0.445

High

234760

O46067
Hypoxia up-regulated protein 1

1

4

High-throughput

0.445

High

426711

HP1
Heterochromatin protein 1

1

1

High-throughput

0.445

High

556700

PSA1
Proteasome subunit alpha type-1

1

1

High-throughput

0.445

High

561796

MODU
DNA-binding protein modulo

1

1

High-throughput

0.445

High

611499

PSA4
Proteasome subunit alpha type-4

1

2

High-throughput

0.445

High

648906

ANXB9
Annexin B9

1

2

High-throughput

0.445

High

649064

ANX10
Annexin B10

1

2

High-throughput

0.445

High

652755

PSA71
Proteasome subunit alpha type-7-1

1

1

High-throughput

0.445

High

726378

VATB
V-type proton ATPase subunit B

1

3

High-throughput

0.445

High

762571

UCHL
Ubiquitin carboxyl-terminal hydrolase

1

3

High-throughput

0.445

High

822058

PSB1
Proteasome subunit beta type-1

1

4

High-throughput

0.445

High

856045

MOEH
Moesin/ezrin/radixin homolog 1

1

1

High-throughput

0.445

High

871635

FKB12
Peptidyl-prolyl cis-trans isomerase Fkbp12

1

4

High-throughput

0.445

High

875235

TCPG
T-complex protein 1 subunit gamma

1

1

High-throughput

0.445

High

929508

PDI
Protein disulfide-isomerase

1

2

High-throughput

0.445

High

1019609

TRXR1
Thioredoxin reductase 1, mitochondrial

1

2

High-throughput

0.445

High

1019878

1433E
14-3-3 protein epsilon

1

1

High-throughput

0.445

High

1052240

HMGD
High mobility group protein D

1

1

High-throughput

0.445

High

1052422

ATPB
ATP synthase subunit beta, mitochondrial

1

1

High-throughput

0.445

High

1176279

VATA2
V-type proton ATPase catalytic subunit A isoform 2

1

2

High-throughput

0.445

High

1176547

NLP
Nucleoplasmin-like protein

1

1

High-throughput

0.445

High

1264665

Q7K148
Proteasome subunit beta

1

1

High-throughput

0.445

High

1265791

Q7K3J0
T-complex protein 1 subunit theta

1

2

High-throughput

0.445

High

1267249

Q7KKI0
T-complex protein 1 subunit epsilon

1

2

High-throughput

0.445

High

1267903

TERA
Transitional endoplasmic reticulum ATPase TER94

1

4

High-throughput

0.445

High

1268073

Q7KN85
ATP-citrate synthase

1

1

High-throughput

0.445

High

1269442

Q7KTW5
Inositol-1-monophosphatase

1

1

High-throughput

0.445

High

1303901

Q8INK3
Fatty acid-binding protein, muscle

1

1

High-throughput

0.445

High

1305243

Q8IQ97
Pebble, isoform B

1

3

High-throughput

0.445

High

1321955

Q8MYY7
RE44624p

1

2

High-throughput

0.445

High

1343302

OLA1
Obg-like ATPase 1

1

1

High-throughput

0.445

High

1345248

THIO2
Thioredoxin-2

1

1

High-throughput

0.445

High

1345250

PSA3
Proteasome subunit alpha type-3

1

3

High-throughput

0.445

High

1345255

Q9VAC4
GEO09167p1

1

1

High-throughput

0.445

High

1345257

Q9VAY2
Heat shock protein 83

1

4

High-throughput

0.445

High

1345263

Q9VEB1
Malate dehydrogenase, mitochondrial

1

2

High-throughput

0.445

High

1345264

FLNA
Filamin-A

1

2

High-throughput

0.445

High

1345269

Q9VH81
protein-serine/threonine phosphatase

1

3

High-throughput

0.445

High

1345279

Q9VK69
T-complex protein 1 subunit delta

1

1

High-throughput

0.445

High

1345282

Q9VKZ8
Ubiquitin carboxyl-terminal hydrolase

1

2

High-throughput

0.445

High

1345286

FKB59
FK506-binding protein 59

1

4

High-throughput

0.445

High

1345287

Q9VL89
Methionine aminopeptidase 2

1

1

High-throughput

0.445

High

1345289

AK200
A-kinase anchor protein 200

1

3

High-throughput

0.445

High

1345290

SYAC
Alanine--tRNA ligase, cytoplasmic

1

1

High-throughput

0.445

High

1345294

Q9VN44
FI07923p

1

1

High-throughput

0.445

High

1345295

PSB4
Proteasome subunit beta type-4

1

5

High-throughput

0.445

High

1345298

Q9VPN5
Stress-induced-phosphoprotein 1

1

6

High-throughput

0.445

High

1345302

Q9VQL1
serine--tRNA ligase

1

1

High-throughput

0.445

High

1345304

Q9VRD6
NTF2-related export protein

1

1

High-throughput

0.445

High

1345308

Q9VSL2
Glutathione S transferase O3

1

1

High-throughput

0.445

High

1345312

Q9VUC1
Hsc70Cb, isoform A

1

8

High-throughput

0.445

High

1345325

Q9VXQ5
Chaperonin containing TCP1 subunit 6

1

1

High-throughput

0.445

High

1345326

CLIC
Chloride intracellular channel Clic

1

1

High-throughput

0.445

High

1345336

Q9W227
Peptidyl-prolyl cis-trans isomerase

1

1

High-throughput

0.445

High

1345343

WUHO
tRNA

1

1

High-throughput

0.445

High

1345347

PSB3
Proteasome subunit beta type-3

1

3

High-throughput

0.445

High

1345348

Q9XYZ9
Glutathione S transferase E12, isoform A

1

2

High-throughput

0.445

High

1345350

PSA6
Proteasome subunit alpha type-6

1

4

High-throughput

0.445

High

57802

A1ZB77
Uncharacterized protein, isoform J

1

0

High-throughput

0.426

High

145972

UGDH
UDP-glucose 6-dehydrogenase

1

0

High-throughput

0.426

High

195060

O16043
Anon1A4

1

0

High-throughput

0.426

High

234584

VINC
Vinculin

1

0

High-throughput

0.426

High

305214

TRMB
tRNA

1

0

High-throughput

0.426

High

305674

IPYR
Inorganic pyrophosphatase

1

0

High-throughput

0.426

High

357532

INO1
Inositol-3-phosphate synthase

1

0

High-throughput

0.426

High

458109

G3P2
Glyceraldehyde-3-phosphate dehydrogenase 2

1

0

High-throughput

0.426

High

460079

ALF
Fructose-bisphosphate aldolase

1

0

High-throughput

0.426

High

476967

NDKA
Nucleoside diphosphate kinase

1

0

High-throughput

0.426

High

578101

ENO
Enolase

1

0

High-throughput

0.426

High

609416

PCNA
Proliferating cell nuclear antigen

1

0

High-throughput

0.426

High

632963

GLNA1
Glutamine synthetase 1, mitochondrial

1

0

High-throughput

0.426

High

682768

PROF
Profilin

1

0

High-throughput

0.426

High

835156

6PGD
6-phosphogluconate dehydrogenase, decarboxylating

1

0

High-throughput

0.426

High

928986

DOD
Putative peptidyl-prolyl cis-trans isomerase dodo

1

0

High-throughput

0.426

High

930159

VATE
V-type proton ATPase subunit E

1

0

High-throughput

0.426

High

1031209

PGK
Phosphoglycerate kinase

1

0

High-throughput

0.426

High

1069903

Q0E993
Valine--tRNA ligase

1

0

High-throughput

0.426

High

1260817

Q76NR6
Regucalcin

1

0

High-throughput

0.426

High

1263000

Q7JXC4
CG6459 protein

1

0

High-throughput

0.426

High

1264117

Q7K0E6
Aspartate--tRNA ligase, cytoplasmic

1

0

High-throughput

0.426

High

1268244

Q7KN99
Phosphopantothenoylcysteine synthetase, isoform A

1

0

High-throughput

0.426

High

1305713

Q8IQZ7
FI19014p1

1

0

High-throughput

0.426

High

1321663

Q8MT58
Carnosine dipeptidase 2, isoform A

1

0

High-throughput

0.426

High

1342998

Q8STA5
Histidine triad nucleotide binding protein 1, isoform A

1

0

High-throughput

0.426

High

1345231

NACA
Nascent polypeptide-associated complex subunit alpha

1

0

High-throughput

0.426

High

1345234

FAXC
Failed axon connections

1

0

High-throughput

0.426

High

1345235

IF5A
Eukaryotic translation initiation factor 5A

1

0

High-throughput

0.426

High

1345236

JUPIT
Microtubule-associated protein Jupiter

1

0

High-throughput

0.426

High

1345237

NASP
Nuclear autoantigenic sperm protein homolog

1

0

High-throughput

0.426

High

1345238

PUR6
Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase

1

0

High-throughput

0.426

High

1345239

SH3BG
SH3 domain-binding glutamic acid-rich protein homolog

1

0

High-throughput

0.426

High

1345242

Q9V3I1
Deoxyuridine 5'-triphosphate nucleotidohydrolase

1

0

High-throughput

0.426

High

1345243

JIL1
Chromosomal serine/threonine-protein kinase JIL-1

1

0

High-throughput

0.426

High

1345246

SPC25
Kinetochore protein Spc25

1

0

High-throughput

0.426

High

1345247

Q9V3V9
Endonuclease G inhibitor, isoform A

1

0

High-throughput

0.426

High

1345252

AN32A
Acidic leucine-rich nuclear phosphoprotein 32 family member A

1

0

High-throughput

0.426

High

1345253

Q9V9U3
LD45254p

1

0

High-throughput

0.426

High

1345268

TCTP
Translationally-controlled tumor protein homolog

1

0

High-throughput

0.426

High

1345270

TEBPH
Cytosolic Prostaglandin E synthase

1

0

High-throughput

0.426

High

1345271

Q9VHL2
T-complex protein 1 subunit eta

1

0

High-throughput

0.426

High

1345273

DPP3
Dipeptidyl peptidase 3

1

0

High-throughput

0.426

High

1345276

Q9VII9
Glyoxylate reductase/hydroxypyruvate reductase

1

0

High-throughput

0.426

High

1345280

Q9VKB0
threonine--tRNA ligase

1

0

High-throughput

0.426

High

1345291

Q9VLS7
LD21067p

1

0

High-throughput

0.426

High

1345292

Q9VLX0
Alpha-aminoadipic semialdehyde synthase, mitochondrial

1

0

High-throughput

0.426

High

1345293

Q9VMU6
LD31822p

1

0

High-throughput

0.426

High

1345299

Q9VPX6
Adenylyl cyclase-associated protein

1

0

High-throughput

0.426

High

1345301

BACC
Bacchus

1

0

High-throughput

0.426

High

1345310

Q9VU35
10 kDa heat shock protein, mitochondrial

1

0

High-throughput

0.426

High

1345313

GARS
Glycine--tRNA ligase

1

0

High-throughput

0.426

High

1345315

Y9705
Cold shock domain-containing protein CG9705

1

0

High-throughput

0.426

High

1345320

RS10B
Small ribosomal subunit protein eS10B

1

0

High-throughput

0.426

High

1345324

Q9VXQ3
Diphosphomevalonate decarboxylase

1

0

High-throughput

0.426

High

1345330

Q9VZY0
LD45195p

1

0

High-throughput

0.426

High

1345332

Q9W0E4
Aminopeptidase

1

0

High-throughput

0.426

High

1345333

Q9W0H8
Reticulocalbin-3

1

0

High-throughput

0.426

High

1345335

SND1
Staphylococcal nuclease domain-containing protein 1

1

0

High-throughput

0.426

High

1345338

Q9W2M4
Farnesoic acid O-methyl transferase domain-containing protein

1

0

High-throughput

0.426

High

1345339

Q9W3F6
Bleomycin hydrolase

1

0

High-throughput

0.426

High

1345341

Q9W3Y3
Calcyclin-binding protein

1

0

High-throughput

0.426

High

1345344

Q9W457
Serine hydroxymethyltransferase

1

0

High-throughput

0.426

High

1345346

NSUN2
tRNA

1

0

High-throughput

0.426

High

1345349

Q9XZ57
Eb1, isoform E

1

0

High-throughput

0.426

High

1345351

PURA
Adenylosuccinate synthetase

1

0

High-throughput

0.426

High

54026

A1Z892
1-Cys peroxiredoxin

1

2

High-throughput

0.407

High

121252

ALDR
Aldo-keto reductase 1B

1

4

High-throughput

0.407

High

197797

HCD2
3-hydroxyacyl-CoA dehydrogenase type-2

1

2

High-throughput

0.407

High

821860

PSA2
Proteasome subunit alpha type-2

1

2

High-throughput

0.407

High

1176715

SAHH
Adenosylhomocysteinase

1

1

High-throughput

0.407

High

1191662

Q3YMU0
Protein disulfide-isomerase

1

1

High-throughput

0.407

High

1262130

Q7JVH6
LD24696p

1

4

High-throughput

0.407

High

1262820

Q7JX87
1-Cys peroxiredoxin

1

2

High-throughput

0.407

High

1345233

SUCA
Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial

1

1

High-throughput

0.407

High

1345244

Q9V3Q4
thioredoxin-dependent peroxiredoxin

1

2

High-throughput

0.407

High

1345245

Q9V3V2
peptidylprolyl isomerase

1

4

High-throughput

0.407

High

1345249

PDIA6
Protein disulfide-isomerase A6 homolog

1

2

High-throughput

0.407

High

1345251

TPP2
Tripeptidyl-peptidase 2

1

2

High-throughput

0.407

High

1345256

Q9VAN7
Phosphoglycerate mutase

1

1

High-throughput

0.407

High

1345262

Q9VD29
small monomeric GTPase

1

4

High-throughput

0.407

High

1345267

Q9VGK3
peptidylprolyl isomerase

1

4

High-throughput

0.407

High

1345274

Q9VHX4
LD24679p

1

4

High-throughput

0.407

High

1345278

Q9VJD4
LD24721p

1

6

High-throughput

0.407

High

1345284

Q9VL68
Enoyl-CoA delta isomerase 1, mitochondrial

1

1

High-throughput

0.407

High

1345303

Q9VQL7
Fatty acid synthase

1

1

High-throughput

0.407

High

1345306

Q9VRP2
Uncharacterized protein, isoform A

1

1

High-throughput

0.407

High

1345309

Q9VTY2
Uncharacterized protein, isoform A

1

4

High-throughput

0.407

High

1345317

Q9VVL7
Dihydrolipoyl dehydrogenase

1

2

High-throughput

0.407

High

1345319

Q9VW70
FI21813p1

1

1

High-throughput

0.407

High

1345328

TXND5
Thioredoxin domain-containing protein 5 homolog

1

3

High-throughput

0.407

High

1345329

Q9VZI1
Transgelin

1

1

High-throughput

0.407

High

1345331

Q9W022
GEO01508p1

1

2

High-throughput

0.407

High

1345334

Q9W0L7
ubiquitinyl hydrolase 1

1

1

High-throughput

0.407

High

1345340

Q9W3X6
fumarate hydratase

1

1

High-throughput

0.407

High

1345342

CISY
Probable citrate synthase, mitochondrial

1

1

High-throughput

0.407

High

1345352

Q9Y112
BcDNA.GH10614

1

4

High-throughput

0.407

High

86516

B9EQV3
Endoplasmic reticulum transmembrane protein

1

0

High-throughput

0.232

Low

304647

RS21
Small ribosomal subunit protein eS21

1

0

High-throughput

0.232

Low

357311

O97428
Ciboulot, isoform A

1

0

High-throughput

0.232

Low

657775

VATL
V-type proton ATPase 16 kDa proteolipid subunit c

1

0

High-throughput

0.232

Low

712367

CALR
Calreticulin

1

0

High-throughput

0.232

Low

874667

RIR2
Ribonucleoside-diphosphate reductase subunit M2

1

0

High-throughput

0.232

Low

1070766

Q0KHZ6
Electron transfer flavoprotein subunit beta

1

0

High-throughput

0.232

Low

1265245

Q7K2K2
FI04612p

1

0

High-throughput

0.232

Low

1266795

EIF3J
Eukaryotic translation initiation factor 3 subunit J

1

0

High-throughput

0.232

Low

1306091

Q8IRD3
Glutathione peroxidase

1

0

High-throughput

0.232

Low

1345232

ACPM
Acyl carrier protein, mitochondrial

1

0

High-throughput

0.232

Low

1345240

CP2B
Cardio acceleratory peptide 2b

1

0

High-throughput

0.232

Low

1345254

Q9VAC1
GM14349p

1

0

High-throughput

0.232

Low

1345258

Q9VBR6
RE74917p

1

0

High-throughput

0.232

Low

1345259

Q9VBT1
CHK kinase-like domain-containing protein

1

0

High-throughput

0.232

Low

1345260

Q9VCK6
LD34157p

1

0

High-throughput

0.232

Low

1345261

Q9VD02
GH14779p

1

0

High-throughput

0.232

Low

1345265

Q9VG31
Malic enzyme

1

0

High-throughput

0.232

Low

1345266

Q9VG33
Sulfurtransferase

1

0

High-throughput

0.232

Low

1345272

Q9VHN7
transketolase

1

0

High-throughput

0.232

Low

1345275

Q9VIE8
Aconitate hydratase, mitochondrial

1

0

High-throughput

0.232

Low

1345277

Q9VJ59
PRA1 family protein

1

0

High-throughput

0.232

Low

1345281

Q9VKW5
Prolyl endopeptidase

1

0

High-throughput

0.232

Low

1345283

EF1D
Probable elongation factor 1-delta

1

0

High-throughput

0.232

Low

1345285

Q9VL70
HL08109p

1

0

High-throughput

0.232

Low

1345288

Q9VLB7
Rab GDP dissociation inhibitor

1

0

High-throughput

0.232

Low

1345297

Q9VP52
GH24315p

1

0

High-throughput

0.232

Low

1345300

Q9VQ61
Aspartate aminotransferase

1

0

High-throughput

0.232

Low

1345307

Q9VSI6
Isocitrate dehydrogenase [NADP]

1

0

High-throughput

0.232

Low

1345311

WDR1
Actin-interacting protein 1

1

0

High-throughput

0.232

Low

1345316

Q9VVC5
2-oxoglutarate dehydrogenase, mitochondrial

1

0

High-throughput

0.232

Low

1345318

Q9VW59
Rho GDP-dissociation inhibitor 3

1

0

High-throughput

0.232

Low

1345322

Q9VWQ7
Coactosin-like protein

1

0

High-throughput

0.232

Low

1345323

DHB4
Peroxisomal multifunctional enzyme type 2

1

0

High-throughput

0.232

Low

1345337

Q9W258
Babos, isoform A

1

0

High-throughput

0.232

Low

1345345

Q9W478
RE43153p

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025