Protein: SAE2
SUMO-activating enzyme subunit 2 (EC 2.3.2.-) (Anthracycline-associated resistance ARX) (Ubiquitin-like 1-activating enzyme E1B) (Ubiquitin-like modifier-activating enzyme 2)

Gene: SAE2, UBA2
Organism: Homo sapiens
Interactions: 104
UniProt ID: Q9UBT2

Gene Ontology (top 5):
GO:0000287 - magnesium ion binding
GO:0005524 - ATP binding
GO:0005654 - nucleoplasm
GO:0005730 - nucleolus
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1458333

SAE1
SUMO-activating enzyme subunit 1

19

12

Small-scale

0.988

High

993787

UBC9
SUMO-conjugating enzyme UBC9

17

20

Small-scale

0.987

High

991448

SUMO1
Small ubiquitin-related modifier 1

10

10

Small-scale

0.975

High

964489

SUMO2
Small ubiquitin-related modifier 2

3

10

Small-scale

0.834

High

508765

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

2

14

Small-scale

0.778

High

1458711

SAE2
SUMO-activating enzyme subunit 2

2

10

Small-scale

0.778

High

243192

PRKN
E3 ubiquitin-protein ligase parkin

2

8

High-throughput

0.754

High

107819

SUMO5
Small ubiquitin-related modifier 5

1

10

High-throughput

0.665

High

182006

UBD
Ubiquitin D

1

15

Small-scale

0.647

High

1154948

NEDD8
Ubiquitin-like protein NEDD8

1

5

Small-scale

0.647

High

939236

SUMO3
Small ubiquitin-related modifier 3

1

10

Small-scale

0.618

High

971234

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

20

High-throughput

0.618

High

1408152

BAG1
BAG family molecular chaperone regulator 1

1

1

High-throughput

0.618

High

276797

TBCA
Tubulin-specific chaperone A

3

0

High-throughput

0.613

High

1335035

SERB1
SERPINE1 mRNA-binding protein 1

2

4

Small-scale

0.586

High

1439078

CPNE5
Copine-5

2

1

High-throughput

0.574

High

1215527

CE162
Centrosomal protein of 162 kDa

2

1

High-throughput

0.571

High

1291375

LCA5
Lebercilin

2

1

High-throughput

0.571

High

1051333

KPCZ
Protein kinase C zeta type

1

1

High-throughput

0.536

High

1151677

TRIP6
Thyroid receptor-interacting protein 6

1

1

High-throughput

0.536

High

1351893

NEK7
Serine/threonine-protein kinase Nek7

1

1

High-throughput

0.536

High

1406652

HCD2
3-hydroxyacyl-CoA dehydrogenase type-2

1

2

High-throughput

0.536

High

1381215

UB2E3
Ubiquitin-conjugating enzyme E2 E3

1

19

Small-scale

0.516

High

163184

CHK1
Serine/threonine-protein kinase Chk1

1

2

Small-scale

0.501

High

1042936

ERCC6
DNA excision repair protein ERCC-6

1

3

High-throughput

0.501

High

1458717

SAR1B
Small COPII coat GTPase SAR1B

1

4

High-throughput

0.489

High

1275979

SETX
Probable helicase senataxin

1

0

Small-scale

0.486

High

1404915

PARK7
Parkinson disease protein 7

1

0

Small-scale

0.486

High

894221

MEOX2
Homeobox protein MOX-2

1

1

High-throughput

0.481

High

1351492

BRX1
Ribosome biogenesis protein BRX1 homolog

1

1

High-throughput

0.481

High

846940

ETV4
ETS translocation variant 4

1

0

Small-scale

0.480

High

143305

NFIB
Nuclear factor 1 B-type

1

1

High-throughput

0.479

High

260569

BRD4
Bromodomain-containing protein 4

1

3

High-throughput

0.479

High

347972

BAG3
BAG family molecular chaperone regulator 3

1

1

High-throughput

0.479

High

363970

EGFR
Epidermal growth factor receptor

1

1

High-throughput

0.479

High

412749

NTRK1
High affinity nerve growth factor receptor

1

4

High-throughput

0.479

High

414769

P53
Cellular tumor antigen p53

1

2

High-throughput

0.479

High

474345

NFIC
Nuclear factor 1 C-type

1

1

High-throughput

0.479

High

487848

PARP1
Poly [ADP-ribose] polymerase 1

1

1

High-throughput

0.479

High

589937

RFA2
Replication protein A 32 kDa subunit

1

5

High-throughput

0.479

High

607187

CEBPB
CCAAT/enhancer-binding protein beta

1

5

High-throughput

0.479

High

696759

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

3

High-throughput

0.479

High

769413

RFA3
Replication protein A 14 kDa subunit

1

4

High-throughput

0.479

High

831582

CCNF
Cyclin-F

1

2

High-throughput

0.479

High

890607

RBP2
E3 SUMO-protein ligase RanBP2

1

1

Small-scale

0.479

High

935237

TERA
Transitional endoplasmic reticulum ATPase

1

5

High-throughput

0.479

High

986788

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

1

High-throughput

0.479

High

1097606

CBX3
Chromobox protein homolog 3

1

1

High-throughput

0.479

High

1100489

TIF1B
Transcription intermediary factor 1-beta

1

2

High-throughput

0.479

High

1114543

CUL3
Cullin-3

1

4

High-throughput

0.479

High

1122577

IKKE
Inhibitor of nuclear factor kappa-B kinase subunit epsilon

1

1

High-throughput

0.479

High

1255937

TRI67
Tripartite motif-containing protein 67

1

11

High-throughput

0.479

High

1324099

RHG24
Rho GTPase-activating protein 24

1

3

High-throughput

0.479

High

1364289

TOPB1
DNA topoisomerase 2-binding protein 1

1

3

High-throughput

0.479

High

1364652

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

3

High-throughput

0.479

High

1370432

CSN5
COP9 signalosome complex subunit 5

1

4

High-throughput

0.479

High

1405699

NECD
Necdin

1

2

High-throughput

0.479

High

1434133

PKHA4
Pleckstrin homology domain-containing family A member 4

1

7

High-throughput

0.479

High

1453014

TLS1
Splicing factor C9orf78

1

1

High-throughput

0.479

High

1458713

ZRAN1
Ubiquitin thioesterase ZRANB1

1

4

High-throughput

0.479

High

1458714

HERC5
E3 ISG15--protein ligase HERC5

1

11

Small-scale

0.479

High

1458715

FND3A
Fibronectin type-III domain-containing protein 3A

1

2

High-throughput

0.479

High

1458716

TRAF6
TNF receptor-associated factor 6

1

4

High-throughput

0.479

High

1232620

Q6FHY5
MEOX2 protein

1

1

High-throughput

0.470

High

163845

TCRG1
Transcription elongation regulator 1

1

0

High-throughput

0.458

High

189024

TMPS2
Transmembrane protease serine 2

1

0

High-throughput

0.458

High

192756

ARPC5
Actin-related protein 2/3 complex subunit 5

1

0

High-throughput

0.458

High

659622

CRCM
Colorectal mutant cancer protein

1

0

High-throughput

0.458

High

879575

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

0

High-throughput

0.458

High

961651

PHS
Pterin-4-alpha-carbinolamine dehydratase

1

0

High-throughput

0.458

High

1041344

CAV1
Caveolin-1

1

0

High-throughput

0.458

High

1135837

HAPR1
HUWE1-associated protein modifying stress responses 1

1

0

Small-scale

0.458

High

1419718

GTPB4
GTP-binding protein 4

1

0

Small-scale

0.458

High

1433103

CHM4B
Charged multivesicular body protein 4b

1

0

High-throughput

0.458

High

1449239

RAD18
E3 ubiquitin-protein ligase RAD18

1

0

High-throughput

0.458

High

1452452

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

0

High-throughput

0.458

High

1458712

DAXX
Death domain-associated protein 6

1

0

Small-scale

0.458

High

1450167

Q9NUW4
Ribosome biogenesis protein BRX1 homolog

1

1

High-throughput

0.457

High

330354

VENTX
Homeobox protein VENTX

1

4

High-throughput

0.445

High

564499

CFTR
Cystic fibrosis transmembrane conductance regulator

1

2

High-throughput

0.445

High

765966

BMI1
Polycomb complex protein BMI-1

1

4

High-throughput

0.445

High

1315724

DND1
Dead end protein homolog 1

1

1

High-throughput

0.445

High

1335892

RN169
E3 ubiquitin-protein ligase RNF169

1

2

Small-scale

0.445

High

1420749

ZDHC5
Palmitoyltransferase ZDHHC5

1

1

High-throughput

0.445

High

1449904

DDX28
Probable ATP-dependent RNA helicase DDX28

1

2

High-throughput

0.445

High

130272

PGRC1
Membrane-associated progesterone receptor component 1

1

1

Small-scale

0.437

High

318899

RHBT1
Rho-related BTB domain-containing protein 1

1

5

High-throughput

0.437

High

488884

FURIN
Furin

1

1

High-throughput

0.437

High

659851

SAHH
Adenosylhomocysteinase

1

1

High-throughput

0.437

High

1050563

UBE3A
Ubiquitin-protein ligase E3A

1

13

High-throughput

0.437

High

1420150

EDEM3
ER degradation-enhancing alpha-mannosidase-like protein 3

1

1

Small-scale

0.437

High

1390444

PELI1
E3 ubiquitin-protein ligase pellino homolog 1

1

0

Small-scale

0.426

High

1416733

OSB11
Oxysterol-binding protein-related protein 11

1

0

High-throughput

0.426

High

887293

CEBPA
CCAAT/enhancer-binding protein alpha

1

5

High-throughput

0.408

High

142434

PEX7
Peroxisomal targeting signal 2 receptor

1

3

High-throughput

0.407

High

1418495

ACE2
Angiotensin-converting enzyme 2

2

0

High-throughput

0.305

High

290191

OFD1
Centriole and centriolar satellite protein OFD1

2

0

High-throughput

0.298

High

1417693

TX101
Testis-expressed protein 101

1

0

High-throughput

0.279

Low

380176

HLAB
HLA class I histocompatibility antigen, B alpha chain

1

0

High-throughput

0.249

Low

842669

WASP
Actin nucleation-promoting factor WAS

1

0

Small-scale

0.249

Low

1194632

DUS28
Dual specificity phosphatase 28

1

0

High-throughput

0.249

Low

1414491

DERL1
Derlin-1

1

0

Small-scale

0.249

Low

1446824

GPC5C
G-protein coupled receptor family C group 5 member C

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025