HitPredict

Interactor 1: SUMO5 (G2XKQ0)
Small ubiquitin-related modifier 5 (SUMO-5) (SUMO1 pseudogene 1) (Ubiquitin-like 2) (Ubiquitin-like 6)
Gene: SUMO1P1

Interactor 2: SAE2 (Q9UBT2)
SUMO-activating enzyme subunit 2 (EC 2.3.2.-) (Anthracycline-associated resistance ARX) (Ubiquitin-like 1-activating enzyme E1B) (Ubiquitin-like modifier-activating enzyme 2)
Gene: UBA2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.44	1.00	0.665

Property	Details
Experiments	25416956
Identification Methods	two hybrid prey pooling approach, two hybrid array, validated two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Rad60-SLD~ThiF
Common GO terms	GO:0016925 - protein sumoylation
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 101 Hs			1 640
+	Hs
		991448 SUMO1_HUMAN (1-101): 4.49e-42: 134: 88.12		SAE2_HUMAN (1-640): 0: 716: 100.00
+	Hs
		964489 SUMO2_HUMAN (1-97): 9.63e-39: 126: 44.33		SAE2_HUMAN (1-640): 0: 716: 100.00
+	Hs
		939236 SUMO3_HUMAN (1-97): 8.4e-38: 124: 46.39		SAE2_HUMAN (1-640): 0: 716: 100.00
+	Rn
		73329 SUMO3_RAT (1-100): 7.82e-40: 129: 45.00		B1WC32_RAT (1-640): 0: 693: 94.38
+	Dm
		356355 O97102_DROME (1-98): 2.69e-37: 122: 45.92		Q7KUA4_DROME (2-631): 0: 569: 46.11
+	Sp
		149269 PMT3_SCHPO (10-99): 4.36e-38: 125: 50.00		UBA2_SCHPO (9-627): 7.89e-175: 513: 34.59
+	Sc
		912384 SMT3_YEAST (1-99): 3.19e-33: 112: 43.56		UBA2_YEAST (3-640): 2.22e-168: 496: 33.33
+	Rn
		1216900 SUMO3_RAT (1-100): 7.82e-40: 129: 45.00		UBA1_RAT (6-634): 8.86e-60: 218: 12.81
+	Hs
		647526 SUMO2_HUMAN (1-97): 9.63e-39: 126: 44.33		UBA1_HUMAN (6-634): 1.15e-60: 221: 13.71
+	Dm
		356374 O97102_DROME (1-98): 2.69e-37: 122: 45.92		Q8T0L3_DROME (6-634): 2.27e-42: 166: 13.18