HitPredict

Interactor 1: ABL1 (P00519)
Tyrosine-protein kinase ABL1 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 1) (Abelson tyrosine-protein kinase 1) (Proto-oncogene c-Abl) (p150)
Gene: ABL1

Interactor 2: ASAP1 (Q9ULH1)
Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 (130 kDa phosphatidylinositol 4,5-bisphosphate-dependent ARF1 GTPase-activating protein) (ADP-ribosylation factor-directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (DEF-1) (Differentiation-enhancing factor 1) (PIP2-dependent ARF1 GAP)
Gene: ASAP1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	17474147
Identification Methods	peptide array
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PH~PK_Tyr_Ser-Thr, PK_Tyr_Ser-Thr~SH3_9, Ank_2~SH3_1, PH~SH3_1
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 1130 Hs			1 1129
+	Hs
		362293 ABL1_HUMAN (1-1130): 0: 987: 100.00		ACAP1_HUMAN (45-688): 1.13e-152: 475: 20.79
+	Hs
		557518 SRC_HUMAN (13-510): 0: 547: 38.58		ASAP1_HUMAN (17-1129): 0: 826: 100.00
+	Hs
		440782 FYN_HUMAN (18-510): 0: 543: 38.64		ASAP1_HUMAN (17-1129): 0: 826: 100.00
+	Hs
		473483 HCK_HUMAN (9-508): 2.76e-174: 524: 38.79		ASAP1_HUMAN (17-1129): 0: 826: 100.00
+	Hs
		840901 TEC_HUMAN (40-502): 3.78e-153: 473: 37.05		ASAP1_HUMAN (17-1129): 0: 826: 100.00
+	Hs
		207909 SRC_HUMAN (13-510): 0: 547: 38.58		ASAP2_HUMAN (21-967): 0: 644: 55.31
+	Hs
		207903 FYN_HUMAN (18-510): 0: 543: 38.64		ASAP2_HUMAN (21-967): 0: 644: 55.31
+	Hs
		207904 YES_HUMAN (5-510): 5.81e-179: 536: 39.42		ASAP2_HUMAN (21-967): 0: 644: 55.31
+	Hs
		557312 SRC_HUMAN (13-510): 0: 547: 38.58		ACAP1_HUMAN (45-688): 1.13e-152: 475: 20.79
+	Mm
		73887 B2RQ57_MOUSE (10-1130): 0: 645: 44.42		AGAP2_MOUSE (379-660): 1.65e-87: 309: 29.02
+	Mm
		431343 SRC_MOUSE (13-510): 0: 544: 38.19		AGAP2_MOUSE (379-660): 1.65e-87: 309: 29.02
+	Hs
		557529 SRC_HUMAN (13-510): 0: 547: 38.58		AGAP1_HUMAN (361-662): 3.34e-62: 230: 28.30
+	Hs
		440655 FYN_HUMAN (18-510): 0: 543: 38.64		ARAP2_HUMAN (162-622): 1.63e-59: 226: 18.76
+	Hs
		440161 LCK_HUMAN (9-508): 2.02e-177: 531: 38.49		ARAP2_HUMAN (162-622): 1.63e-59: 226: 18.76
+	Hs
		463685 LYN_HUMAN (9-508): 2.82e-172: 518: 36.15		ARAP2_HUMAN (162-622): 1.63e-59: 226: 18.76