HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: RASH (P01112)
GTPase HRas (EC 3.6.5.2) (H-Ras-1) (Ha-Ras) (Transforming protein p21) (c-H-ras) (p21ras) [Cleaved into: GTPase HRas, N-terminally processed]
Gene: HRAS

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score Annotation score Interaction score
0.56 1.00 0.754

The method score is based on:

Property Details
Experiments 30639242, 30194290
Identification Methods proximity labelling technology
Interaction Type physical association

The annotation score is based on:

Property Details
Interacting Pfam domains PK_Tyr_Ser-Thr~Ras
Common GO terms GO:0000139 - Golgi membrane
GO:0005737 - cytoplasm
GO:0005789 - endoplasmic reticulum membrane
GO:0005794 - Golgi apparatus
GO:0005829 - cytosol
and 12 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 1210
Hs

1 189
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Service provided by Combinatics, Japan

Last updated: 11Aug2025