HitPredict

Interactor 1: RAF1 (P04049)
RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Proto-oncogene c-RAF) (cRaf) (Raf-1)
Gene: RAF1

Interactor 2: MPRIP (Q6WCQ1)
Myosin phosphatase Rho-interacting protein (M-RIP) (Rho-interacting protein 3) (RIP3) (p116Rip)
Gene: MPRIP

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	36244648
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	C1_1~PH, PH~Pkinase
Common GO terms	GO:0005829 - cytosol
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 648 Hs			1 1025
+	Hs
		374648 RAF1_HUMAN (1-648): 0: 652: 100.00		CNKR1_HUMAN (351-693): 2.42e-66: 239: 21.04
+	Hs
		374582 RAF1_HUMAN (1-648): 0: 652: 100.00		DLG5_HUMAN (647-1019): 8.88e-54: 207: 21.61
+	Mm
		936589 RAF1_MOUSE (1-648): 0: 647: 97.69		ROCK2_MOUSE (502-969): 1.57e-40: 165: 18.71
+	Hs
		148266 RAF1_HUMAN (1-648): 0: 652: 100.00		CTRO_HUMAN (195-1019): 1.45e-35: 149: 11.42
+	Hs
		373790 RAF1_HUMAN (1-648): 0: 652: 100.00		MYH9_HUMAN (540-1015): 1.52e-17: 90.5: 9.66
+	Hs
		373791 RAF1_HUMAN (1-648): 0: 652: 100.00		MYH10_HUMAN (534-1014): 3.94e-16: 85.9: 9.18
+	Hs
		373794 RAF1_HUMAN (1-648): 0: 652: 100.00		MYH11_HUMAN (124-786): 1.25e-12: 74.7: 11.57
+	Hs
		374260 RAF1_HUMAN (1-648): 0: 652: 100.00		PLEC_HUMAN (499-978): 3.1e-11: 70.1: 14.96
+	Hs
		374446 RAF1_HUMAN (1-648): 0: 652: 100.00		MYH14_HUMAN (595-972): 3.69e-09: 63.1: 14.89
+	Hs
		1153279 KSR1_HUMAN (138-648): 6.15e-108: 348: 24.61		PKHA7_HUMAN (336-980): 5.04e-41: 166: 13.51
+	Hs
		433388 YES_HUMAN (329-607): 1.22e-105: 332: 33.92		PKHA7_HUMAN (336-980): 5.04e-41: 166: 13.51
+	Hs
		1217987 KSR1_HUMAN (138-648): 6.15e-108: 348: 24.61		PKHA5_HUMAN (318-1019): 7.56e-36: 149: 13.24
+	Hs
		111443 J3QRU1_HUMAN (329-607): 1.4e-105: 332: 33.92		MYH9_HUMAN (540-1015): 1.52e-17: 90.5: 9.66
+	Hs
		433272 YES_HUMAN (329-607): 1.22e-105: 332: 33.92		MYH9_HUMAN (540-1015): 1.52e-17: 90.5: 9.66
+	Hs
		412058 FYN_HUMAN (337-607): 2.33e-103: 326: 34.55		MYH9_HUMAN (540-1015): 1.52e-17: 90.5: 9.66