HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: ICAM1 (P05362)
Intercellular adhesion molecule 1 (ICAM-1) (Major group rhinovirus receptor) (CD antigen CD54)
Gene: ICAM1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.64 0.60 0.621

The method score is based on:

Property Details
Experiments 39499777, 16799092
Identification Methods proximity labelling technology, affinity chromatography technology, pull down, anti bait coimmunoprecipitation
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0001618 - virus receptor activity
GO:0004888 - transmembrane signaling receptor activity
GO:0005615 - extracellular space
GO:0005886 - plasma membrane
GO:0005925 - focal adhesion
and 4 others

more...
Homologous interactions 14

Homologous interactions

Color coding for hit scores

1 1210
Hs

1 532
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Service provided by Combinatics, Japan

Last updated: 11Aug2025