HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: ROR1 (Q01973)
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (Neurotrophic tyrosine kinase, receptor-related 1)
Gene: ROR1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	22439932
Identification Methods	anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type	association, physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~PK_Tyr_Ser-Thr
Common GO terms	GO:0004714 - transmembrane receptor protein tyrosine kinase activity GO:0005524 - ATP binding GO:0005737 - cytoplasm GO:0005886 - plasma membrane GO:0009986 - cell surface and 1 others more... GO:0043235 - receptor complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1210 Hs			1 937
+	Hs
		362824 EGFR_HUMAN (1-1210): 0: 1246: 100.00		EPHA2_HUMAN (12-806): 5.74e-161: 498: 18.91
+	Hs
		363031 EGFR_HUMAN (1-1210): 0: 1246: 100.00		EPHA5_HUMAN (12-807): 3.15e-160: 498: 17.94
+	Hs
		363317 EGFR_HUMAN (1-1210): 0: 1246: 100.00		ERBB4_HUMAN (111-932): 1.47e-143: 461: 18.35
+	Hs
		362616 EGFR_HUMAN (1-1210): 0: 1246: 100.00		RET_HUMAN (170-849): 6.03e-144: 458: 22.46
+	Hs
		362836 EGFR_HUMAN (1-1210): 0: 1246: 100.00		UFO_HUMAN (25-830): 5.25e-145: 455: 18.47
+	Hs
		710252 ERBB4_HUMAN (1-1208): 0: 1155: 49.12		EPHA2_HUMAN (12-806): 5.74e-161: 498: 18.91
+	Rn
		1224337 ERBB4_RAT (7-1208): 0: 1158: 49.04		ERBB4_RAT (109-932): 1.32e-143: 461: 17.94
+	Hs
		363343 EGFR_HUMAN (1-1210): 0: 1246: 100.00		NTRK2_HUMAN (435-754): 9.47e-115: 372: 41.75
+	Hs
		1145733 ERBB4_HUMAN (1-1208): 0: 1155: 49.12		ERBB4_HUMAN (111-932): 1.47e-143: 461: 18.35
+	Hs
		410531 ERBB2_HUMAN (5-1203): 0: 1119: 48.38		RET_HUMAN (170-849): 6.03e-144: 458: 22.46
+	Hs
		1145737 ERBB4_HUMAN (1-1208): 0: 1155: 49.12		NTRK2_HUMAN (435-754): 9.47e-115: 372: 41.75
+	Hs
		362573 EGFR_HUMAN (1-1210): 0: 1246: 100.00		NTRK1_HUMAN (478-748): 5.74e-72: 255: 46.89
+	Rn
		204713 Q9QX70_RAT (1-1210): 0: 1250: 90.34		FAK1_RAT (461-836): 2.12e-53: 204: 34.65
+	Hs
		362619 EGFR_HUMAN (1-1210): 0: 1246: 100.00		IGF1R_HUMAN (467-742): 3.43e-54: 207: 39.71
+	Hs
		364020 EGFR_HUMAN (1-1210): 0: 1246: 100.00		ALK_HUMAN (404-746): 1.75e-53: 205: 35.20
+	Hs
		410506 ERBB2_HUMAN (5-1203): 0: 1119: 48.38		NTRK1_HUMAN (478-748): 5.74e-72: 255: 46.89
+	Hs
		410576 ERBB2_HUMAN (5-1203): 0: 1119: 48.38		INSRR_HUMAN (467-742): 1.33e-55: 211: 39.35
+	Hs
		410532 ERBB2_HUMAN (5-1203): 0: 1119: 48.38		IGF1R_HUMAN (467-742): 3.43e-54: 207: 39.71
+	Hs
		410614 ERBB2_HUMAN (5-1203): 0: 1119: 48.38		EPHA1_HUMAN (479-746): 1.35e-53: 204: 41.42
+	Hs
		410559 ERBB2_HUMAN (5-1203): 0: 1119: 48.38		FGFR1_HUMAN (43-182): 7.17e-13: 74.9: 17.61