HitPredict

Interactor 1: EPHA2 (P29317)
Ephrin type-A receptor 2 (EC 2.7.10.1) (Epithelial cell kinase) (Tyrosine-protein kinase receptor ECK)
Gene: EPHA2

Interactor 2: ERBB4 (Q15303)
Receptor tyrosine-protein kinase erbB-4 (EC 2.7.10.1) (Proto-oncogene-like protein c-ErbB-4) (Tyrosine kinase-type cell surface receptor HER4) (p180erbB4) [Cleaved into: ERBB4 intracellular domain (4ICD) (E4ICD) (s80HER4)]
Gene: ERBB4

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	36976175
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	EphA2_TM~PK_Tyr_Ser-Thr, Furin-like~fn3, PK_Tyr_Ser-Thr~fn3, Recep_L_domain~fn3, PK_Tyr_Ser-Thr~PK_Tyr_Ser-Thr, PK_Tyr_Ser-Thr~SAM_1
Common GO terms	GO:0004714 - transmembrane receptor protein tyrosine kinase activity GO:0005524 - ATP binding GO:0005886 - plasma membrane GO:0007169 - cell surface receptor protein tyrosine kinase signaling pathway GO:0016477 - cell migration and 1 others more... GO:0043235 - receptor complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 976 Hs			1 1308
+	Hs
		410643 EPHA2_HUMAN (1-976): 0: 1124: 100.00		ERBB2_HUMAN (25-1274): 0: 1094: 45.98
+	Hs
		410733 EPHA5_HUMAN (11-976): 0: 1115: 51.34		ERBB2_HUMAN (25-1274): 0: 1094: 45.98
+	Hs
		362824 EPHA2_HUMAN (1-976): 0: 1124: 100.00		EGFR_HUMAN (20-1286): 0: 1028: 48.70
+	Hs
		363031 EPHA5_HUMAN (11-976): 0: 1115: 51.34		EGFR_HUMAN (20-1286): 0: 1028: 48.70
+	Mm
		362442 EPHA4_MOUSE (1-974): 0: 1113: 50.56		ABL1_MOUSE (693-1305): 1.75e-127: 423: 24.32
+	Hs
		710073 EPHA2_HUMAN (1-976): 0: 1124: 100.00		EPHA2_HUMAN (671-1010): 6.91e-119: 396: 35.41
+	Hs
		710255 EPHA7_HUMAN (4-974): 0: 1120: 50.15		EPHA2_HUMAN (671-1010): 6.91e-119: 396: 35.41
+	Hs
		710076 EPHA2_HUMAN (1-976): 0: 1124: 100.00		EPHB2_HUMAN (647-987): 1.81e-116: 391: 34.45
+	Mm
		1041404 EPHA4_MOUSE (1-974): 0: 1113: 50.56		EPHA4_MOUSE (666-1067): 1.12e-119: 399: 30.43
+	Hs
		710141 EPHA5_HUMAN (11-976): 0: 1115: 51.34		EPHA2_HUMAN (671-1010): 6.91e-119: 396: 35.41
+	Hs
		710837 EPHA7_HUMAN (4-974): 0: 1120: 50.15		EPHB2_HUMAN (647-987): 1.81e-116: 391: 34.45
+	Mm
		932041 EPHA4_MOUSE (1-974): 0: 1113: 50.56		EPHB2_MOUSE (649-989): 1.3e-119: 398: 33.89
+	Hs
		710192 EPHA2_HUMAN (1-976): 0: 1124: 100.00		FAK1_HUMAN (703-997): 6.58e-59: 223: 39.53
+	Hs
		710107 EPHA2_HUMAN (1-976): 0: 1124: 100.00		ABL2_HUMAN (713-980): 1.37e-55: 214: 42.59
+	Hs
		840960 EPHA7_HUMAN (4-974): 0: 1120: 50.15		ABL2_HUMAN (713-980): 1.37e-55: 214: 42.59
+	Hs
		710074 EPHA2_HUMAN (1-976): 0: 1124: 100.00		EPHA3_HUMAN (705-987): 6.2e-54: 207: 39.10
+	Hs
		710630 EPHA7_HUMAN (4-974): 0: 1120: 50.15		EPHA3_HUMAN (705-987): 6.2e-54: 207: 39.10
+	Hs
		710612 EPHA5_HUMAN (11-976): 0: 1115: 51.34		EPHA3_HUMAN (705-987): 6.2e-54: 207: 39.10
+	Hs
		465419 EPHA2_HUMAN (1-976): 0: 1124: 100.00		IGF1R_HUMAN (333-691): 3.64e-32: 138: 18.37
+	Hs
		439654 EPHA2_HUMAN (1-976): 0: 1124: 100.00		INSR_HUMAN (353-660): 1.04e-31: 137: 19.05