HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: SEPT9 (Q9UHD8)
Septin-9 (MLL septin-like fusion protein MSF-A) (MLL septin-like fusion protein) (Ovarian/Breast septin) (Ov/Br septin) (Septin D1)
Gene: SEPTIN9

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	35384245
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005929 - cilium GO:0045296 - cadherin binding GO:0048471 - perinuclear region of cytoplasm
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 1210 Hs			1 586
+	Hs
		363978 EGFR_HUMAN (1-1210): 0: 1246: 100.00		SEPT3_HUMAN (254-568): 1.52e-167: 482: 67.49
+	Hs
		363651 EGFR_HUMAN (1-1210): 0: 1246: 100.00		SEPT8_HUMAN (266-584): 3.1e-164: 478: 39.38
+	Hs
		363951 EGFR_HUMAN (1-1210): 0: 1246: 100.00		SEP10_HUMAN (263-582): 9.07e-165: 478: 39.56
+	Hs
		363272 EGFR_HUMAN (1-1210): 0: 1246: 100.00		SEPT6_HUMAN (277-583): 5.88e-163: 473: 41.56
+	Hs
		410973 ERBB2_HUMAN (5-1203): 0: 1119: 48.38		SEPT8_HUMAN (266-584): 3.1e-164: 478: 39.38
+	Hs
		410836 ERBB2_HUMAN (5-1203): 0: 1119: 48.38		SEPT6_HUMAN (277-583): 5.88e-163: 473: 41.56
+	Hs
		710912 EPHB2_HUMAN (642-1067): 2.14e-123: 408: 28.22		SEPT9_HUMAN (1-586): 0: 979: 100.00
+	Hs
		464023 RET_HUMAN (412-1058): 7.91e-132: 433: 23.02		SEPT8_HUMAN (266-584): 3.1e-164: 478: 39.38
+	Hs
		710911 EPHB2_HUMAN (642-1067): 2.14e-123: 408: 28.22		SEPT3_HUMAN (254-568): 1.52e-167: 482: 67.49
+	Hs
		710872 EPHB2_HUMAN (642-1067): 2.14e-123: 408: 28.22		SEPT8_HUMAN (266-584): 3.1e-164: 478: 39.38
+	Hs
		710908 EPHB2_HUMAN (642-1067): 2.14e-123: 408: 28.22		SEP10_HUMAN (263-582): 9.07e-165: 478: 39.56
+	Hs
		710830 EPHB2_HUMAN (642-1067): 2.14e-123: 408: 28.22		SEPT6_HUMAN (277-583): 5.88e-163: 473: 41.56
+	Hs
		1121179 EPHA7_HUMAN (653-1064): 3.04e-119: 396: 27.51		SEPT6_HUMAN (277-583): 5.88e-163: 473: 41.56
+	Hs
		465595 IGF1R_HUMAN (438-1062): 5.28e-109: 375: 20.53		SEPT8_HUMAN (266-584): 3.1e-164: 478: 39.38
+	Hs
		465675 IGF1R_HUMAN (438-1062): 5.28e-109: 375: 20.53		SEP10_HUMAN (263-582): 9.07e-165: 478: 39.56
+	Hs
		465516 IGF1R_HUMAN (438-1062): 5.28e-109: 375: 20.53		SEPT6_HUMAN (277-583): 5.88e-163: 473: 41.56
+	Hs
		439809 INSR_HUMAN (336-637): 2.63e-27: 122: 21.64		SEPT8_HUMAN (266-584): 3.1e-164: 478: 39.38