HitPredict

Interactor 1: ESR1 (P03372)
Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1)
Gene: ESR1

Interactor 2: PABP1 (P11940)
Polyadenylate-binding protein 1 (PABP-1) (Poly(A)-binding protein 1)
Gene: PABPC1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	33731348, 21182205
Identification Methods	affinity chromatography technology, cosedimentation through density gradient
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0016020 - membrane
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 595 Hs			1 636
+	Hs
		370422 ESR1_HUMAN (1-595): 0: 599: 100.00		PABP3_HUMAN (1-636): 0: 541: 91.37
+	Hs
		369534 ESR1_HUMAN (1-595): 0: 599: 100.00		PABP4_HUMAN (1-635): 0: 534: 74.69
+	Hs
		369739 ESR1_HUMAN (1-595): 0: 599: 100.00		PAP1L_HUMAN (1-628): 9.51e-166: 489: 68.20
+	Hs
		1269600 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		PABP3_HUMAN (1-636): 0: 541: 91.37
+	Hs
		1031409 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		PABP4_HUMAN (1-635): 0: 534: 74.69
+	Hs
		516359 NR4A1_HUMAN (64-549): 2.81e-105: 331: 24.54		PABP1_HUMAN (1-636): 0: 582: 100.00
+	Mm
		509289 RARA_MOUSE (81-545): 8.36e-104: 323: 22.37		PABP1_MOUSE (1-636): 0: 581: 99.69
+	Hs
		1119140 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		PAP1L_HUMAN (1-628): 9.51e-166: 489: 68.20
+	Hs
		782537 HNF4A_HUMAN (146-592): 2.13e-118: 361: 20.58		PABP4_HUMAN (1-635): 0: 534: 74.69
+	Hs
		611434 NR4A1_HUMAN (64-549): 2.81e-105: 331: 24.54		PABP4_HUMAN (1-635): 0: 534: 74.69
+	Hs
		369064 ESR1_HUMAN (1-595): 0: 599: 100.00		TIA1_HUMAN (4-172): 1.71e-42: 159: 28.57
+	Hs
		370176 ESR1_HUMAN (1-595): 0: 599: 100.00		PABP5_HUMAN (6-179): 5.04e-39: 149: 25.26
+	Hs
		487081 ANDR_HUMAN (172-455): 8.95e-37: 148: 30.16		PABP1_HUMAN (1-636): 0: 582: 100.00
+	Hs
		368961 ESR1_HUMAN (1-595): 0: 599: 100.00		NUCL_HUMAN (3-89): 2.56e-19: 94.1: 33.33
+	Hs
		680471 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		TIA1_HUMAN (4-172): 1.71e-42: 159: 28.57
+	Hs
		1269332 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		PABP5_HUMAN (6-179): 5.04e-39: 149: 25.26
+	Hs
		582413 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		NUCL_HUMAN (3-89): 2.56e-19: 94.1: 33.33
+	Hs
		377077 GCR_HUMAN (5-557): 4.67e-109: 346: 22.51		NUCL_HUMAN (3-89): 2.56e-19: 94.1: 33.33