HitPredict

Interactor 1: ESR1 (P03372)
Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1)
Gene: ESR1

Interactor 2: FLII (Q13045)
Protein flightless-1 homolog
Gene: FLII

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.66	0.60	0.629

Property	Details
Experiments	14966289, 19720835
Identification Methods	pull down, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 595 Hs			1 1269
+	Hs
		1023211 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		FLII_HUMAN (1-1269): 0: 1206: 100.00
+	Hs
		368817 ESR1_HUMAN (1-595): 0: 599: 100.00		GELS_HUMAN (481-1269): 0: 798: 24.85
+	Hs
		487386 ANDR_HUMAN (172-455): 8.95e-37: 148: 30.16		FLII_HUMAN (1-1269): 0: 1206: 100.00
+	Hs
		414017 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		GELS_HUMAN (481-1269): 0: 798: 24.85
+	Hs
		93996 F1D8P7_HUMAN (103-548): 1.37e-102: 320: 21.43		GELS_HUMAN (481-1269): 0: 798: 24.85
+	Hs
		413810 ANDR_HUMAN (172-455): 8.95e-37: 148: 30.16		GELS_HUMAN (481-1269): 0: 798: 24.85
+	Hs
		370255 ESR1_HUMAN (1-595): 0: 599: 100.00		ERBIN_HUMAN (10-376): 1.85e-23: 110: 28.27
+	Hs
		313719 ESR1_HUMAN (1-595): 0: 599: 100.00		SVIL_HUMAN (1056-1267): 1.52e-21: 104: 17.69
+	Hs
		370727 ESR1_HUMAN (1-595): 0: 599: 100.00		SHOC2_HUMAN (191-379): 8.7e-15: 81.3: 27.62
+	Hs
		1270065 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		SCIN_HUMAN (906-1269): 3.84e-72: 258: 18.04
+	Hs
		377027 GCR_HUMAN (5-557): 4.67e-109: 346: 22.51		VILI_HUMAN (892-1269): 3.51e-57: 215: 15.42
+	Hs
		1269418 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		ERBIN_HUMAN (10-376): 1.85e-23: 110: 28.27
+	Hs
		1269493 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		LRRC1_HUMAN (116-379): 5.94e-20: 97.1: 29.76
+	Hs
		1269946 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		SHOC2_HUMAN (191-379): 8.7e-15: 81.3: 27.62
+	Hs
		313722 GCR_HUMAN (5-557): 4.67e-109: 346: 22.51		SVIL_HUMAN (1056-1267): 1.52e-21: 104: 17.69
+	Hs
		1301470 NR2E1_HUMAN (171-549): 5.7e-110: 336: 29.12		ERBIN_HUMAN (10-376): 1.85e-23: 110: 28.27
+	Hs
		914680 ERR3_HUMAN (91-547): 2.27e-116: 355: 33.77		MFHA1_HUMAN (2-289): 1.38e-16: 87.8: 27.43
+	Hs
		313768 PPARG_HUMAN (55-546): 2.12e-100: 316: 20.35		SVIL_HUMAN (1056-1267): 1.52e-21: 104: 17.69
+	Hs
		740630 PPARG_HUMAN (55-546): 2.12e-100: 316: 20.35		MFHA1_HUMAN (2-289): 1.38e-16: 87.8: 27.43
+	Hs
		313734 ANDR_HUMAN (172-455): 8.95e-37: 148: 30.16		SVIL_HUMAN (1056-1267): 1.52e-21: 104: 17.69