HitPredict

Interactor 1: ESR1 (P03372)
Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1)
Gene: ESR1

Interactor 2: TBB3 (Q13509)
Tubulin beta-3 chain (Tubulin beta-4 chain) (Tubulin beta-III)
Gene: TUBB3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	25604459
Identification Methods	tandem affinity purification
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 595 Hs			1 450
+	Hs
		369732 ESR1_HUMAN (1-595): 0: 599: 100.00		TBB8_HUMAN (1-427): 0: 705: 87.59
+	Hs
		368829 ESR1_HUMAN (1-595): 0: 599: 100.00		TBB5_HUMAN (1-429): 0: 704: 93.94
+	Hs
		370338 ESR1_HUMAN (1-595): 0: 599: 100.00		TBB6_HUMAN (1-446): 0: 700: 92.38
+	Hs
		1037333 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		TBB3_HUMAN (1-450): 0: 723: 100.00
+	Hs
		1046531 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		TBB2A_HUMAN (1-430): 0: 700: 93.49
+	Hs
		381259 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		TBB4A_HUMAN (1-427): 0: 699: 93.21
+	Hs
		320154 ERR2_HUMAN (92-547): 4.3e-116: 354: 34.86		TBB5_HUMAN (1-429): 0: 704: 93.94
+	Hs
		377012 GCR_HUMAN (5-557): 4.67e-109: 346: 22.51		TBB5_HUMAN (1-429): 0: 704: 93.94
+	Hs
		377239 GCR_HUMAN (5-557): 4.67e-109: 346: 22.51		TBB4B_HUMAN (1-427): 0: 703: 93.91
+	Rn
		415143 GCR_RAT (5-557): 9.7e-106: 338: 22.68		TBB2B_RAT (1-430): 0: 703: 93.72
+	Hs
		381124 NR4A1_HUMAN (64-549): 2.81e-105: 331: 24.54		TBB4A_HUMAN (1-427): 0: 699: 93.21
+	Hs
		428059 PPARG_HUMAN (55-546): 2.12e-100: 316: 20.35		TBB5_HUMAN (1-429): 0: 704: 93.94
+	Hs
		414415 PRGR_HUMAN (183-508): 6.92e-44: 170: 32.14		TBB5_HUMAN (1-429): 0: 704: 93.94
+	Hs
		414483 PRGR_HUMAN (183-508): 6.92e-44: 170: 32.14		TBB4B_HUMAN (1-427): 0: 703: 93.91