HitPredict

Interactor 1: ESR1 (P03372)
Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1)
Gene: ESR1

Interactor 2: MPRIP (Q6WCQ1)
Myosin phosphatase Rho-interacting protein (M-RIP) (Rho-interacting protein 3) (RIP3) (p116Rip)
Gene: MPRIP

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.66	0.60	0.633

Property	Details
Experiments	26487511, 31527615, unassigned1953
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 595 Hs			1 1025
+	Hs
		1167393 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		MPRIP_HUMAN (1-1025): 9.29e-127: 412: 100.00
+	Hs
		370068 ESR1_HUMAN (1-595): 0: 599: 100.00		DLG5_HUMAN (647-1019): 8.88e-54: 207: 21.61
+	Hs
		370417 ESR1_HUMAN (1-595): 0: 599: 100.00		TARA_HUMAN (231-985): 1.44e-51: 201: 35.57
+	Hs
		369813 ESR1_HUMAN (1-595): 0: 599: 100.00		PKHA7_HUMAN (336-980): 5.04e-41: 166: 13.51
+	Hs
		370723 ESR1_HUMAN (1-595): 0: 599: 100.00		CE164_HUMAN (163-980): 5.02e-36: 150: 11.93
+	Hs
		148263 ESR1_HUMAN (1-595): 0: 599: 100.00		CTRO_HUMAN (195-1019): 1.45e-35: 149: 11.42
+	Hs
		369096 ESR1_HUMAN (1-595): 0: 599: 100.00		MYH9_HUMAN (540-1015): 1.52e-17: 90.5: 9.66
+	Hs
		368902 ESR1_HUMAN (1-595): 0: 599: 100.00		MYH6_HUMAN (559-1024): 5.56e-13: 75.9: 9.79
+	Hs
		369641 ESR1_HUMAN (1-595): 0: 599: 100.00		PLEC_HUMAN (499-978): 3.1e-11: 70.1: 14.96
+	Hs
		255273 ESR1_HUMAN (1-595): 0: 599: 100.00		HIP1R_HUMAN (626-929): 1.25e-09: 64.5: 19.56
+	Hs
		369901 ESR1_HUMAN (1-595): 0: 599: 100.00		MYH14_HUMAN (595-972): 3.69e-09: 63.1: 14.89
+	Hs
		1255114 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		DLG5_HUMAN (647-1019): 8.88e-54: 207: 21.61
+	Hs
		1150622 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		MRCKG_HUMAN (599-998): 1.13e-44: 178: 19.48
+	Hs
		1153313 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		PKHA7_HUMAN (336-980): 5.04e-41: 166: 13.51
+	Hs
		149132 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		CTRO_HUMAN (195-1019): 1.45e-35: 149: 11.42
+	Hs
		724944 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		MYH9_HUMAN (540-1015): 1.52e-17: 90.5: 9.66
+	Hs
		522631 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		MYH7_HUMAN (101-931): 7.33e-17: 88.6: 10.36
+	Hs
		1068618 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		PLEC_HUMAN (499-978): 3.1e-11: 70.1: 14.96
+	Hs
		255345 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		HIP1R_HUMAN (626-929): 1.25e-09: 64.5: 19.56
+	Hs
		1189781 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		MYH14_HUMAN (595-972): 3.69e-09: 63.1: 14.89