HitPredict

Interactor 1: ESR1 (P03372)
Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1)
Gene: ESR1

Interactor 2: PHB2 (Q99623)
Prohibitin-2 (B-cell receptor-associated protein BAP37) (D-prohibitin) (Repressor of estrogen receptor activity)
Gene: PHB2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.92 0.60 0.746

The method score is based on:

Property Details
Experiments 15140878, 17932104, 10938099, 26052702, 12943695, 28555617, 10359819
Identification Methods pull down, affinity chromatography technology, two hybrid
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0005886 - plasma membrane
GO:0030331 - nuclear estrogen receptor binding
GO:0030520 - estrogen receptor signaling pathway
and 4 others

more...
Homologous interactions 12

Homologous interactions

Color coding for hit scores

1 595
Hs

1 299
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024