HitPredict

Interactor 1: ESR1 (P03372)
Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1)
Gene: ESR1

Interactor 2: MTCH2 (Q9Y6C9)
Mitochondrial carrier homolog 2 (Met-induced mitochondrial protein)
Gene: MTCH2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.67	0.60	0.636

Property	Details
Experiments	31527615, 15604093, unassigned1953
Identification Methods	affinity chromatography technology, two hybrid, tandem affinity purification
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0016020 - membrane
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 595 Hs			1 303
+	Hs
		370664 ESR1_HUMAN (1-595): 0: 599: 100.00		S2513_HUMAN (100-302): 1.38e-37: 143: 16.91
+	Hs
		368888 ESR1_HUMAN (1-595): 0: 599: 100.00		ADT3_HUMAN (113-299): 3.27e-29: 114: 14.00
+	Hs
		368809 ESR1_HUMAN (1-595): 0: 599: 100.00		ADT2_HUMAN (113-299): 1.34e-28: 113: 13.50
+	Hs
		370060 ESR1_HUMAN (1-595): 0: 599: 100.00		S2540_HUMAN (1-109): 2.67e-14: 74.2: 17.43
+	Hs
		1270050 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		MTCH2_HUMAN (1-303): 6.71e-85: 259: 100.00
+	Hs
		369817 ESR1_HUMAN (1-595): 0: 599: 100.00		SCMC1_HUMAN (209-301): 1.92e-11: 66.1: 10.75
+	Hs
		213761 ESR1_HUMAN (1-595): 0: 599: 100.00		MCAT_HUMAN (4-100): 4.15e-11: 64.5: 9.28
+	Hs
		1269876 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		S2513_HUMAN (100-302): 1.38e-37: 143: 16.91
+	Hs
		397461 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		ADT2_HUMAN (113-299): 1.34e-28: 113: 13.50
+	Hs
		274592 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		S2512_HUMAN (4-115): 2e-18: 87.3: 14.29
+	Hs
		1253072 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		S2540_HUMAN (1-109): 2.67e-14: 74.2: 17.43
+	Hs
		1156214 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		SCMC1_HUMAN (209-301): 1.92e-11: 66.1: 10.75
+	Hs
		320164 ERR2_HUMAN (92-547): 4.3e-116: 354: 34.86		ADT3_HUMAN (113-299): 3.27e-29: 114: 14.00
+	Hs
		320152 ERR2_HUMAN (92-547): 4.3e-116: 354: 34.86		ADT2_HUMAN (113-299): 1.34e-28: 113: 13.50
+	Hs
		518086 NR4A1_HUMAN (64-549): 2.81e-105: 331: 24.54		ADT1_HUMAN (113-299): 2e-28: 112: 13.78
+	Hs
		397226 PRGR_HUMAN (183-508): 6.92e-44: 170: 32.14		ADT2_HUMAN (113-299): 1.34e-28: 113: 13.50
+	Hs
		487083 ANDR_HUMAN (172-455): 8.95e-37: 148: 30.16		ADT3_HUMAN (113-299): 3.27e-29: 114: 14.00
+	Hs
		397238 ANDR_HUMAN (172-455): 8.95e-37: 148: 30.16		ADT2_HUMAN (113-299): 1.34e-28: 113: 13.50