HitPredict

Interactor 1: RPB3 (P19387)
DNA-directed RNA polymerase II subunit RPB3 (RNA polymerase II subunit 3) (RNA polymerase II subunit B3) (DNA-directed RNA polymerase II 33 kDa polypeptide) (RPB33) (DNA-directed RNA polymerase II subunit C) (RPB31)
Gene: POLR2C

Interactor 2: RPB1B (Q9GZM3)
DNA-directed RNA polymerase II subunit RPB11-b1 (RNA polymerase II subunit B11-b1) (RPB11b1) (DNA-directed RNA polymerase II subunit J2)
Gene: POLR2J2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	1.00	0.768

Property	Details
Experiments	34079125, 37222571
Identification Methods	proximity labelling technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	RNA_pol_L~RNA_pol_L_2
Common GO terms	GO:0001055 - RNA polymerase II activity GO:0003677 - DNA binding GO:0005665 - RNA polymerase II, core complex GO:0006366 - transcription by RNA polymerase II GO:0046983 - protein dimerization activity
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 275 Hs			1 115
+	Hs
		583438 RPB3_HUMAN (1-275): 6.89e-138: 391: 100.00		RPB11_HUMAN (1-108): 5.83e-46: 145: 94.50
+	Mm
		956874 RPB3_MOUSE (1-275): 5.66e-138: 391: 99.27		Q3TYI2_MOUSE (1-108): 3.75e-45: 143: 93.58
+	Dm
		333012 O97183_DROME (1-274): 2.46e-129: 369: 69.09		RPB11_DROME (1-108): 3.28e-44: 141: 75.23
+	Hs
		169946 RPAC1_HUMAN (3-269): 1.2e-110: 325: 25.90		RPB1C_HUMAN (1-115): 1.6e-52: 162: 99.13
+	Hs
		169941 RPAC1_HUMAN (3-269): 1.2e-110: 325: 25.90		RPB1B_HUMAN (1-115): 1.03e-51: 160: 100.00
+	Hs
		169818 RPAC1_HUMAN (3-269): 1.2e-110: 325: 25.90		RPB11_HUMAN (1-108): 5.83e-46: 145: 94.50
+	Sc
		558050 RPB3_YEAST (4-271): 9.52e-107: 313: 45.06		RPB11_YEAST (1-107): 9.17e-42: 135: 50.93
+	At
		1104914 NRPB3_ARATH (3-272): 1.3e-101: 300: 39.22		NRPBB_ARATH (1-108): 2.13e-45: 144: 47.71
+	Hs
		169778 RPAC1_HUMAN (3-269): 1.2e-110: 325: 25.90		RPAC2_HUMAN (29-108): 3.17e-34: 116: 32.50
+	At
		1104915 RPD3B_ARATH (3-272): 1.16e-99: 296: 38.03		NRPBB_ARATH (1-108): 2.13e-45: 144: 47.71
+	Sc
		557923 RPB3_YEAST (4-271): 9.52e-107: 313: 45.06		RPAC2_YEAST (14-108): 4.25e-34: 116: 31.58
+	Sp
		741615 RPB3_SCHPO (9-275): 1.43e-99: 295: 43.89		RPB11_SCHPO (1-104): 5.16e-38: 125: 47.12
+	Sp
		293857 RPAC1_SCHPO (3-269): 2.63e-99: 296: 22.80		RPAC2_SCHPO (24-108): 4.9e-33: 113: 36.47
+	Sc
		429651 RPAC1_YEAST (3-261): 1.36e-96: 288: 25.42		RPAC2_YEAST (14-108): 4.25e-34: 116: 31.58
+	Dm
		1368240 Q9VMX3_DROME (3-266): 3.21e-101: 300: 26.42		RPAC2_DROME (31-108): 1.17e-27: 99.3: 30.77
+	Ss
		955989 RPO3_SACS2 (8-263): 3.01e-77: 236: 27.37		RPO11_SACS2 (18-105): 1.37e-25: 93.5: 31.82
+	Mj
		1123053 RPO3_METJA (9-268): 1.15e-62: 197: 27.00		RPO11_METJA (18-107): 8.29e-19: 76.6: 23.47