HitPredict

Interactor 1: RAF1 (P04049)
RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Proto-oncogene c-RAF) (cRaf) (Raf-1)
Gene: RAF1

Interactor 2: MRCKA (Q5VT25)
Serine/threonine-protein kinase MRCK alpha (EC 2.7.11.1) (CDC42-binding protein kinase alpha) (DMPK-like alpha) (Myotonic dystrophy kinase-related CDC42-binding kinase alpha) (MRCK alpha) (Myotonic dystrophy protein kinase-like alpha)
Gene: CDC42BPA

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	36244648
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	C1_1~C1_1, C1_1~Pkinase, Pkinase~Pkinase, Pkinase~Pkinase_C, C1_1~RBD
Common GO terms	GO:0004674 - protein serine/threonine kinase activity GO:0005524 - ATP binding GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0006468 - protein phosphorylation and 1 others more... GO:0106310 - protein serine kinase activity
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 648 Hs			1 1732
+	Hs
		375162 RAF1_HUMAN (1-648): 0: 652: 100.00		MRCKB_HUMAN (1-1731): 0: 1417: 60.38
+	Hs
		148266 RAF1_HUMAN (1-648): 0: 652: 100.00		CTRO_HUMAN (4-1044): 3.09e-128: 447: 24.43
+	Hs
		373769 RAF1_HUMAN (1-648): 0: 652: 100.00		AKT1_HUMAN (13-404): 1.23e-128: 413: 31.51
+	Hs
		375068 RAF1_HUMAN (1-648): 0: 652: 100.00		TNIK_HUMAN (53-905): 4.35e-97: 346: 15.60
+	Hs
		374944 RAF1_HUMAN (1-648): 0: 652: 100.00		LATS2_HUMAN (65-376): 3.53e-75: 275: 41.23
+	Hs
		542826 BRAF_HUMAN (39-647): 1.29e-170: 507: 55.88		AKT1_HUMAN (13-404): 1.23e-128: 413: 31.51
+	Hs
		488588 ARAF_HUMAN (45-646): 4.63e-169: 497: 59.28		AKT1_HUMAN (13-404): 1.23e-128: 413: 31.51
+	At
		84904 Y5169_ARATH (2-630): 8.11e-154: 467: 17.15		CIPKP_ARATH (52-532): 1.18e-133: 427: 19.50
+	Hs
		542923 BRAF_HUMAN (39-647): 1.29e-170: 507: 55.88		LATS2_HUMAN (65-376): 3.53e-75: 275: 41.23
+	Hs
		488811 ARAF_HUMAN (45-646): 4.63e-169: 497: 59.28		LATS2_HUMAN (65-376): 3.53e-75: 275: 41.23
+	Mm
		936589 RAF1_MOUSE (1-648): 0: 647: 97.69		ROCK2_MOUSE (275-1052): 2.96e-23: 110: 12.98
+	Zm
		28095 A0A1D6JP61_MAIZE (273-627): 7.9e-105: 342: 29.14		A0A1D6K201_MAIZE (17-416): 8.52e-126: 405: 29.14
+	Hs
		522810 SRC_HUMAN (331-607): 3.01e-106: 333: 33.45		AKT1_HUMAN (13-404): 1.23e-128: 413: 31.51
+	Mm
		403418 SRC_MOUSE (331-607): 3.87e-105: 330: 33.10		AKT1_MOUSE (13-404): 4.42e-129: 414: 31.27
+	Hs
		412046 FYN_HUMAN (337-607): 2.33e-103: 326: 34.55		AKT1_HUMAN (13-404): 1.23e-128: 413: 31.51
+	Hs
		433510 YES_HUMAN (329-607): 1.22e-105: 332: 33.92		ST38L_HUMAN (66-416): 1.26e-88: 299: 43.15
+	Hs
		523170 SRC_HUMAN (331-607): 3.01e-106: 333: 33.45		LATS2_HUMAN (65-376): 3.53e-75: 275: 41.23