HitPredict

Interactor 1: RASH (P01112)
GTPase HRas (EC 3.6.5.2) (H-Ras-1) (Ha-Ras) (Transforming protein p21) (c-H-ras) (p21ras) [Cleaved into: GTPase HRas, N-terminally processed]
Gene: HRAS

Interactor 2: NGAP (Q9UJF2)
Ras GTPase-activating protein nGAP (RAS protein activator-like 2)
Gene: RASAL2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	30639242
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Ras~RasGAP
Common GO terms	GO:0005829 - cytosol GO:0007165 - signal transduction GO:0060612 - adipose tissue development
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 189 Hs			1 1139
+	Hs
		374268 RASN_HUMAN (1-188): 4.47e-88: 257: 85.64		NGAP_HUMAN (1-1139): 0: 1051: 100.00
+	Hs
		376073 RASK_HUMAN (1-188): 1.61e-84: 249: 86.24		NGAP_HUMAN (1-1139): 0: 1051: 100.00
+	Hs
		976645 RB11A_HUMAN (4-178): 6.31e-73: 220: 33.90		NGAP_HUMAN (1-1139): 0: 1051: 100.00
+	Hs
		373986 RASN_HUMAN (1-188): 4.47e-88: 257: 85.64		DAB2P_HUMAN (5-1138): 0: 963: 55.74
+	Hs
		375605 RASK_HUMAN (1-188): 1.61e-84: 249: 86.24		DAB2P_HUMAN (5-1138): 0: 963: 55.74
+	Hs
		375849 RASK_HUMAN (1-188): 1.61e-84: 249: 86.24		SYGP1_HUMAN (2-1138): 0: 765: 43.10
+	Mm
		104477 RAB2A_MOUSE (4-180): 7.5e-74: 223: 31.84		SYGP1_MOUSE (2-1138): 0: 768: 43.44
+	Mm
		104492 RAB1A_MOUSE (4-186): 2.78e-74: 223: 31.28		SYGP1_MOUSE (2-1138): 0: 768: 43.44
+	Hs
		981344 RAB1A_HUMAN (4-186): 2.78e-74: 223: 31.28		SYGP1_HUMAN (2-1138): 0: 765: 43.10
+	Hs
		976494 RB11A_HUMAN (4-178): 6.31e-73: 220: 33.90		SYGP1_HUMAN (2-1138): 0: 765: 43.10
+	Hs
		375494 RASK_HUMAN (1-188): 1.61e-84: 249: 86.24		IQGA2_HUMAN (87-757): 1.48e-150: 492: 14.63
+	Hs
		373769 RASN_HUMAN (1-188): 4.47e-88: 257: 85.64		RASA1_HUMAN (91-623): 3.29e-142: 457: 26.50
+	Hs
		375171 RASK_HUMAN (1-188): 1.61e-84: 249: 86.24		RASA1_HUMAN (91-623): 3.29e-142: 457: 26.50
+	Hs
		375280 RASK_HUMAN (1-188): 1.61e-84: 249: 86.24		IQGA1_HUMAN (88-751): 1.82e-132: 443: 12.10
+	Hs
		374396 RASH_HUMAN (16-189): 6.27e-73: 219: 100.00		RASA1_HUMAN (91-623): 3.29e-142: 457: 26.50
+	Hs
		374610 RASH_HUMAN (16-189): 6.27e-73: 219: 100.00		RASA2_HUMAN (132-564): 1.35e-118: 388: 22.15
+	Hs
		214514 RASH_HUMAN (16-189): 6.27e-73: 219: 100.00		RASL2_HUMAN (152-690): 1.03e-117: 385: 22.63
+	Hs
		373770 RASN_HUMAN (1-188): 4.47e-88: 257: 85.64		NF1_HUMAN (293-621): 8.78e-89: 317: 26.17
+	Hs
		375172 RASK_HUMAN (1-188): 1.61e-84: 249: 86.24		NF1_HUMAN (293-621): 8.78e-89: 317: 26.17
+	Hs
		374397 RASH_HUMAN (16-189): 6.27e-73: 219: 100.00		NF1_HUMAN (293-621): 8.78e-89: 317: 26.17