HitPredict

Interactor 1: RASK (P01116)
GTPase KRas (EC 3.6.5.2) (K-Ras 2) (Ki-Ras) (c-K-ras) (c-Ki-ras) [Cleaved into: GTPase KRas, N-terminally processed]
Gene: KRAS

Interactor 2: EPHB4 (P54760)
Ephrin type-B receptor 4 (EC 2.7.10.1) (Hepatoma transmembrane kinase) (Tyrosine-protein kinase TYRO11)
Gene: EPHB4

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	34079125
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Ras~fn3, PK_Tyr_Ser-Thr~Ras
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 189 Hs			1 987
+	Hs
		710836 RAB35_HUMAN (4-187): 1.26e-82: 244: 31.28		EPHB2_HUMAN (17-982): 0: 1123: 55.08
+	Hs
		374500 RASH_HUMAN (1-188): 8.44e-87: 254: 86.77		EPHA4_HUMAN (3-977): 0: 1110: 49.90
+	Hs
		931947 RAB35_HUMAN (4-187): 1.26e-82: 244: 31.28		EPHB4_HUMAN (1-987): 0: 1120: 100.00
+	Hs
		373938 RASN_HUMAN (1-189): 3.16e-85: 251: 85.19		EPHA7_HUMAN (3-979): 0: 1106: 48.74
+	Hs
		375210 RASK_HUMAN (16-189): 5.35e-78: 232: 100.00		EPHB2_HUMAN (17-982): 0: 1123: 55.08
+	Hs
		1144913 RAB35_HUMAN (4-187): 1.26e-82: 244: 31.28		EPHA7_HUMAN (3-979): 0: 1106: 48.74
+	Hs
		375322 RASK_HUMAN (16-189): 5.35e-78: 232: 100.00		EPHA4_HUMAN (3-977): 0: 1110: 49.90
+	Hs
		373790 RASN_HUMAN (1-189): 3.16e-85: 251: 85.19		EPHA3_HUMAN (13-978): 0: 1087: 48.20
+	Hs
		710629 RAB35_HUMAN (4-187): 1.26e-82: 244: 31.28		EPHA3_HUMAN (13-978): 0: 1087: 48.20
+	Hs
		375209 RASK_HUMAN (16-189): 5.35e-78: 232: 100.00		EPHA3_HUMAN (13-978): 0: 1087: 48.20
+	Hs
		374420 RASH_HUMAN (1-188): 8.44e-87: 254: 86.77		EPHA2_HUMAN (15-974): 0: 1016: 44.82
+	Hs
		373789 RASN_HUMAN (1-189): 3.16e-85: 251: 85.19		EPHA2_HUMAN (15-974): 0: 1016: 44.82
+	Hs
		710251 RAB35_HUMAN (4-187): 1.26e-82: 244: 31.28		EPHA2_HUMAN (15-974): 0: 1016: 44.82
+	Hs
		375208 RASK_HUMAN (16-189): 5.35e-78: 232: 100.00		EPHA2_HUMAN (15-974): 0: 1016: 44.82
+	Hs
		374399 RASH_HUMAN (1-188): 8.44e-87: 254: 86.77		EPHA1_HUMAN (11-969): 0: 946: 39.96
+	Hs
		375173 RASK_HUMAN (16-189): 5.35e-78: 232: 100.00		EPHA1_HUMAN (11-969): 0: 946: 39.96
+	Hs
		374340 RASH_HUMAN (1-188): 8.44e-87: 254: 86.77		INSR_HUMAN (380-894): 1.74e-134: 440: 29.27
+	Hs
		373733 RASN_HUMAN (1-189): 3.16e-85: 251: 85.19		INSR_HUMAN (380-894): 1.74e-134: 440: 29.27
+	Hs
		375086 RASK_HUMAN (16-189): 5.35e-78: 232: 100.00		INSR_HUMAN (380-894): 1.74e-134: 440: 29.27
+	Hs
		375099 RASK_HUMAN (16-189): 5.35e-78: 232: 100.00		IGF1R_HUMAN (390-876): 7.15e-132: 432: 27.63