HitPredict

Interactor 1: CSF2 (P04141)
Granulocyte-macrophage colony-stimulating factor (GM-CSF) (Colony-stimulating factor) (CSF) (Molgramostin) (Sargramostim)
Gene: CSF2

Interactor 2: IL3RB (P32927)
Cytokine receptor common subunit beta (CDw131) (GM-CSF/IL-3/IL-5 receptor common beta subunit) (CD antigen CD131)
Gene: CSF2RB

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.70	0.60	0.651

Property	Details
Experiments	7957082, 1702217, 18692472
Identification Methods	biochemical, cross-linking study, experimental interaction detection, saturation binding
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0007259 - cell surface receptor signaling pathway via JAK-STAT GO:0030526 - granulocyte macrophage colony-stimulating factor receptor complex GO:0038157 - granulocyte-macrophage colony-stimulating factor signaling pathway GO:0070665 - positive regulation of leukocyte proliferation
Homologous interactions	1

Homologous interactions

Color coding for hit scores

	1 144 Hs			1 897
+	Hs
		376546 CSF2_HUMAN (1-144): 1.69e-104: 296: 100.00		CSF2R_HUMAN (122-479): 7.49e-79: 263: 14.25