Interactor 1: IGF2 (P01344)
Insulin-like growth factor 2 (Insulin-like growth factor II) (IGF-II) (Somatomedin-A) (T3M-11-derived growth factor) [Cleaved into: Insulin-like growth factor II Ala-25 Del; Preptin]
Gene: IGF2
Interactor 2: IDE (P14735)
Insulin-degrading enzyme (EC 3.4.24.56) (Abeta-degrading protease) (Insulin protease) (Insulinase) (Insulysin)
Gene: IDE
Species: Homo sapiens
Source: intact
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.56 | 1.00 | 0.755 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 1733942, unassigned3799 |
| Identification Methods | pull down, anti tag coimmunoprecipitation |
| Interaction Type | direct interaction, association |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | Insulin~Peptidase_M16, Insulin~Peptidase_M16_C, Insulin~Peptidase_M16_M, Insulin~PqqF-like_C_4 |
| Common GO terms | GO:0005615 - extracellular space GO:0008286 - insulin receptor signaling pathway |
| Homologous interactions | 3 |
Homologous interactions
Color coding for hit scores 
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Service provided by Combinatics, Japan
Last updated: 11Aug2025
