Protein: IGF2
Insulin-like growth factor 2 (Insulin-like growth factor II) (IGF-II) (Somatomedin-A) (T3M-11-derived growth factor) [Cleaved into: Insulin-like growth factor II Ala-25 Del; Preptin]

Gene: IGF2
Organism: Homo sapiens
Interactions: 42
UniProt ID: P01344

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0001649 - osteoblast differentiation
GO:0001701 - in utero embryonic development
GO:0001892 - embryonic placenta development
GO:0005158 - insulin receptor binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

377816

IBP3
Insulin-like growth factor-binding protein 3

5

10

Small-scale

0.919

High

377813

IBP1
Insulin-like growth factor-binding protein 1

4

13

Small-scale

0.902

High

377812

IGF1R
Insulin-like growth factor 1 receptor

4

4

High-throughput

0.886

High

377818

IBP4
Insulin-like growth factor-binding protein 4

3

10

Small-scale

0.849

High

377820

IBP5
Insulin-like growth factor-binding protein 5

3

10

Small-scale

0.847

High

377810

INSR
Insulin receptor

3

4

High-throughput

0.839

High

377819

IBP6
Insulin-like growth factor-binding protein 6

2

10

Small-scale

0.799

High

377815

IDE
Insulin-degrading enzyme

2

3

Small-scale

0.755

High

377814

MPRI
Cation-independent mannose-6-phosphate receptor

3

0

Small-scale

0.724

High

377817

IBP2
Insulin-like growth factor-binding protein 2

1

10

High-throughput

0.691

High

377822

CCN3
CCN family member 3

1

2

Small-scale

0.647

High

377825

IBP7
Insulin-like growth factor-binding protein 7

1

3

Small-scale

0.647

High

377835

ANM6
Protein arginine N-methyltransferase 6

2

0

High-throughput

0.576

High

284368

CLN5
Bis(monoacylglycero)phosphate synthase CLN5

2

1

High-throughput

0.553

High

377832

GP152
Probable G-protein coupled receptor 152

2

1

High-throughput

0.553

High

377827

RN123
E3 ubiquitin-protein ligase RNF123

2

3

High-throughput

0.549

High

377830

UBR1
E3 ubiquitin-protein ligase UBR1

2

3

High-throughput

0.549

High

377831

UBR2
E3 ubiquitin-protein ligase UBR2

2

3

High-throughput

0.549

High

377836

UBAC1
Ubiquitin-associated domain-containing protein 1

2

1

High-throughput

0.549

High

377826

PREP
Presequence protease, mitochondrial

1

3

High-throughput

0.514

High

62875

POTEF
POTE ankyrin domain family member F

1

0

High-throughput

0.513

High

229609

CALU
Calumenin

1

0

High-throughput

0.513

High

377842

SUFU
Suppressor of fused homolog

1

0

High-throughput

0.513

High

377808

TRFE
Serotransferrin

1

1

Small-scale

0.501

High

377811

PGS2
Decorin

1

1

Small-scale

0.501

High

377821

BAG6
Large proline-rich protein BAG6

1

1

High-throughput

0.481

High

377809

VTNC
Vitronectin

1

0

Small-scale

0.480

High

377843

FAF1
FAS-associated factor 1

1

2

High-throughput

0.464

High

377828

PCSK4
Proprotein convertase subtilisin/kexin type 4

1

1

Small-scale

0.457

High

377829

CREL2
Protein disulfide isomerase CRELD2

1

1

High-throughput

0.457

High

377834

TRI63
E3 ubiquitin-protein ligase TRIM63

1

3

High-throughput

0.439

High

377837

TRI55
Tripartite motif-containing protein 55

1

3

High-throughput

0.439

High

377840

BIRC6
Dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6

1

0

High-throughput

0.426

High

343666

GGPPS
Geranylgeranyl pyrophosphate synthase

2

0

High-throughput

0.313

High

377833

RBPMS
RNA-binding protein with multiple splicing

1

0

High-throughput

0.299

High

207782

ZZEF1
Zinc finger ZZ-type and EF-hand domain-containing protein 1

1

0

High-throughput

0.279

Low

377823

ATX3
Ataxin-3

1

0

High-throughput

0.279

Low

377839

NRK2
Nicotinamide riboside kinase 2

1

0

High-throughput

0.265

Low

377838

TRI31
E3 ubiquitin-protein ligase TRIM31

1

0

High-throughput

0.249

Low

377841

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.249

Low

229926

SAHH2
S-adenosylhomocysteine hydrolase-like protein 1

1

0

High-throughput

0.232

Low

377824

DCAF7
DDB1- and CUL4-associated factor 7

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025