Protein: PPB1
Alkaline phosphatase, placental type (EC 3.1.3.1) (Alkaline phosphatase Regan isozyme) (Placental alkaline phosphatase 1) (PLAP-1)

Gene: PPB1, ALPP
Organism: Homo sapiens
Interactions: 128
UniProt ID: P05187

Gene Ontology (top 5):
GO:0000287 - magnesium ion binding
GO:0004035 - alkaline phosphatase activity
GO:0005886 - plasma membrane
GO:0008270 - zinc ion binding
GO:0009986 - cell surface

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

398484

PPBI
Intestinal-type alkaline phosphatase

2

4

High-throughput

0.811

High

398486

PPBN
Alkaline phosphatase, germ cell type

2

4

High-throughput

0.811

High

398493

KRA59
Keratin-associated protein 5-9

3

9

High-throughput

0.616

High

283157

RGS20
Regulator of G-protein signaling 20

2

1

High-throughput

0.606

High

398503

RGS19
Regulator of G-protein signaling 19

2

1

High-throughput

0.606

High

398490

TGM1
Protein-glutamine gamma-glutamyltransferase K

2

0

High-throughput

0.580

High

398561

NR4A3
Nuclear receptor subfamily 4 group A member 3

2

0

High-throughput

0.580

High

398487

CFTR
Cystic fibrosis transmembrane conductance regulator

2

3

High-throughput

0.571

High

180967

GSC2
Homeobox protein goosecoid-2

2

3

High-throughput

0.553

High

398502

HXA1
Homeobox protein Hox-A1

2

2

High-throughput

0.553

High

398511

KR108
Keratin-associated protein 10-8

2

8

High-throughput

0.553

High

398515

CREB5
Cyclic AMP-responsive element-binding protein 5

2

1

High-throughput

0.553

High

398517

KRA11
Keratin-associated protein 1-1

2

8

High-throughput

0.553

High

398531

LCE3E
Late cornified envelope protein 3E

2

2

High-throughput

0.553

High

398534

LCE1E
Late cornified envelope protein 1E

2

1

High-throughput

0.553

High

398538

LCE3A
Late cornified envelope protein 3A

2

2

High-throughput

0.553

High

398539

LCE3B
Late cornified envelope protein 3B

2

1

High-throughput

0.553

High

398553

KRA13
Keratin-associated protein 1-3

2

8

High-throughput

0.553

High

398573

LCE3D
Late cornified envelope protein 3D

2

2

High-throughput

0.553

High

230110

MGRN1
E3 ubiquitin-protein ligase MGRN1

1

1

High-throughput

0.536

High

398495

PCSK6
Proprotein convertase subtilisin/kexin type 6

1

1

High-throughput

0.536

High

398520

HYAL2
Hyaluronidase-2

1

1

High-throughput

0.536

High

398521

SEM3B
Semaphorin-3B

1

1

High-throughput

0.536

High

398546

CSPG4
Chondroitin sulfate proteoglycan 4

1

2

High-throughput

0.536

High

398558

PCSK9
Proprotein convertase subtilisin/kexin type 9

1

1

High-throughput

0.536

High

398560

KREM2
Kremen protein 2

1

1

High-throughput

0.536

High

398567

VMP1
Vacuole membrane protein 1

1

2

High-throughput

0.536

High

398580

ANLN
Anillin

2

1

High-throughput

0.533

High

398569

KR412
Keratin-associated protein 4-12

1

8

High-throughput

0.523

High

398488

PDIA4
Protein disulfide-isomerase A4

1

0

High-throughput

0.513

High

398566

I17RA
Interleukin-17 receptor A

1

0

High-throughput

0.513

High

398593

JAG2
Protein jagged-2

1

0

High-throughput

0.513

High

398597

AGRG1
Adhesion G-protein coupled receptor G1

1

0

High-throughput

0.513

High

398584

NLGN3
Neuroligin-3

1

1

Small-scale

0.508

High

135802

MA2B1
Lysosomal alpha-mannosidase

1

1

High-throughput

0.489

High

152067

TOR1B
Torsin-1B

1

3

High-throughput

0.489

High

398483

BGLR
Beta-glucuronidase

1

1

High-throughput

0.489

High

398497

GALNS
N-acetylgalactosamine-6-sulfatase

1

2

High-throughput

0.489

High

398506

ANAG
Alpha-N-acetylglucosaminidase

1

1

High-throughput

0.489

High

398507

LAMB2
Laminin subunit beta-2

1

1

High-throughput

0.489

High

398547

ARSK
Arylsulfatase K

1

2

High-throughput

0.489

High

398551

MEGF8
Multiple epidermal growth factor-like domains protein 8

1

2

High-throughput

0.489

High

398552

ANR46
Ankyrin repeat domain-containing protein 46

1

1

High-throughput

0.489

High

398554

P3H3
Prolyl 3-hydroxylase 3

1

1

High-throughput

0.489

High

398555

FXRD2
FAD-dependent oxidoreductase domain-containing protein 2

1

1

High-throughput

0.489

High

398563

SC65
Endoplasmic reticulum protein SC65

1

1

High-throughput

0.489

High

398585

CHPF2
Chondroitin sulfate glucuronyltransferase

1

1

High-throughput

0.489

High

398595

MA2B2
Epididymis-specific alpha-mannosidase

1

1

High-throughput

0.489

High

325592

LATS1
Serine/threonine-protein kinase LATS1

1

0

Small-scale

0.480

High

167802

NPC1
NPC intracellular cholesterol transporter 1

1

1

High-throughput

0.479

High

398524

NBR1
Next to BRCA1 gene 1 protein

1

1

High-throughput

0.479

High

398572

TX101
Testis-expressed protein 101

1

2

High-throughput

0.479

High

398575

ASPC1
Tether containing UBX domain for GLUT4

1

1

High-throughput

0.479

High

398586

HDAC6
Histone deacetylase 6

1

3

High-throughput

0.479

High

398485

NT2NC
Notch homolog 2 N-terminal-like protein C

1

4

High-throughput

0.470

High

398544

Q6FHY5
MEOX2 protein

1

1

High-throughput

0.470

High

398556

EMC5
ER membrane protein complex subunit 5

1

0

High-throughput

0.458

High

398578

CHM4B
Charged multivesicular body protein 4b

1

0

High-throughput

0.458

High

398512

SUMO1
Small ubiquitin-related modifier 1

1

1

Small-scale

0.445

High

398577

ZDHC5
Palmitoyltransferase ZDHHC5

1

1

High-throughput

0.445

High

459

NBPFJ
Neuroblastoma breakpoint family member 19

1

1

High-throughput

0.439

High

398505

MEOX2
Homeobox protein MOX-2

1

1

High-throughput

0.439

High

398510

KR103
Keratin-associated protein 10-3

1

8

High-throughput

0.439

High

398532

LCE1C
Late cornified envelope protein 1C

1

2

High-throughput

0.439

High

398536

LCE1B
Late cornified envelope protein 1B

1

1

High-throughput

0.439

High

398549

NT2NA
Notch homolog 2 N-terminal-like protein A

1

4

High-throughput

0.439

High

398574

KRA93
Keratin-associated protein 9-3

1

8

High-throughput

0.439

High

299305

UBXN7
UBX domain-containing protein 7

1

3

High-throughput

0.437

High

308312

KI20A
Kinesin-like protein KIF20A

1

7

High-throughput

0.437

High

398514

KIF23
Kinesin-like protein KIF23

1

4

High-throughput

0.437

High

398516

UBXN1
UBX domain-containing protein 1

1

2

High-throughput

0.437

High

398526

KIF14
Kinesin-like protein KIF14

1

2

High-throughput

0.437

High

398564

TF3B
Transcription factor IIIB 90 kDa subunit

1

2

Small-scale

0.437

High

398565

FAF2
FAS-associated factor 2

1

3

High-throughput

0.437

High

398568

AURKB
Aurora kinase B

1

2

High-throughput

0.437

High

398576

UBXN6
UBX domain-containing protein 6

1

1

High-throughput

0.437

High

398579

ECT2
Protein ECT2

1

1

High-throughput

0.437

High

398581

FBX6
F-box only protein 6

1

1

High-throughput

0.437

High

398591

FAF1
FAS-associated factor 1

1

4

High-throughput

0.437

High

398508

SUMO3
Small ubiquitin-related modifier 3

1

1

Small-scale

0.407

High

66948

CRTP1
Cysteine-rich tail protein 1

2

0

High-throughput

0.316

High

398492

IBP6
Insulin-like growth factor-binding protein 6

2

0

High-throughput

0.316

High

398496

OTX1
Homeobox protein OTX1

2

0

High-throughput

0.316

High

398501

CXCL5
C-X-C motif chemokine 5

2

0

High-throughput

0.316

High

398504

MCSP
Sperm mitochondrial-associated cysteine-rich protein

2

0

High-throughput

0.316

High

398509

GEMI4
Gem-associated protein 4

2

0

High-throughput

0.316

High

398519

PO4F2
POU domain, class 4, transcription factor 2

2

0

High-throughput

0.316

High

398530

LCE3C
Late cornified envelope protein 3C

2

0

High-throughput

0.316

High

398533

LCE1D
Late cornified envelope protein 1D

2

0

High-throughput

0.316

High

398535

LCE1F
Late cornified envelope protein 1F

2

0

High-throughput

0.316

High

398537

LELP1
Late cornified envelope-like proline-rich protein 1

2

0

High-throughput

0.316

High

398541

LCE2C
Late cornified envelope protein 2C

2

0

High-throughput

0.316

High

398542

LCE5A
Late cornified envelope protein 5A

2

0

High-throughput

0.316

High

398548

ATL4
ADAMTS-like protein 4

2

0

High-throughput

0.316

High

398582

FBX34
F-box only protein 34

2

0

High-throughput

0.316

High

398587

CRCT1
Cysteine-rich C-terminal protein 1

2

0

High-throughput

0.316

High

398562

GPI8
GPI-anchor transamidase

2

0

Small-scale

0.310

High

398491

BDNF
Brain-derived neurotrophic factor

1

0

High-throughput

0.279

Low

398499

IDUA
Alpha-L-iduronidase

1

0

High-throughput

0.279

Low

398500

COIA1
Collagen alpha-1(XVIII) chain [Cleaved into: Endostatin; Non-collagenous domain 1

1

0

High-throughput

0.279

Low

398513

NAAA
N-acylethanolamine-hydrolyzing acid amidase

1

0

High-throughput

0.279

Low

398518

MGT5A
Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A

1

0

High-throughput

0.279

Low

398527

NOMO1
BOS complex subunit NOMO1

1

0

High-throughput

0.279

Low

398528

GXLT1
Glucoside xylosyltransferase 1

1

0

High-throughput

0.279

Low

398543

METRL
Meteorin-like protein

1

0

High-throughput

0.279

Low

398545

GLT18
Polypeptide N-acetylgalactosaminyltransferase 18

1

0

High-throughput

0.279

Low

398557

PGLT1
Protein O-glucosyltransferase 1

1

0

High-throughput

0.279

Low

398559

UXS1
UDP-glucuronic acid decarboxylase 1

1

0

High-throughput

0.279

Low

398570

EDEM2
ER degradation-enhancing alpha-mannosidase-like protein 2

1

0

High-throughput

0.279

Low

398571

CHID1
Chitinase domain-containing protein 1

1

0

High-throughput

0.279

Low

398583

P4HTM
Transmembrane prolyl 4-hydroxylase

1

0

High-throughput

0.279

Low

398588

SUN2
SUN domain-containing protein 2

1

0

High-throughput

0.279

Low

398589

PCYOX
Prenylcysteine oxidase 1

1

0

High-throughput

0.279

Low

398590

PALD
Paladin

1

0

High-throughput

0.279

Low

398596

LOXL2
Lysyl oxidase homolog 2

1

0

High-throughput

0.279

Low

398540

LCE4A
Late cornified envelope protein 4A

1

0

High-throughput

0.251

Low

398550

NUFP2
FMR1-interacting protein NUFIP2

1

0

High-throughput

0.251

Low

199999

GPAA1
Glycosylphosphatidylinositol anchor attachment 1 protein

1

0

Small-scale

0.249

Low

352971

IL1B
Interleukin-1 beta

1

0

Small-scale

0.249

Low

398489

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.249

Low

398494

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.249

Low

398498

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

398522

DX39B
Spliceosome RNA helicase DDX39B

1

0

Small-scale

0.249

Low

398523

TRI25
E3 ubiquitin/ISG15 ligase TRIM25

1

0

High-throughput

0.249

Low

398525

EMC2
ER membrane protein complex subunit 2

1

0

High-throughput

0.249

Low

398529

UBX11
UBX domain-containing protein 11

1

0

High-throughput

0.249

Low

398592

NSF1C
NSFL1 cofactor p47

1

0

High-throughput

0.249

Low

398594

FBW1A
F-box/WD repeat-containing protein 1A

1

0

Small-scale

0.249

Low


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Last updated: 15 Jul 2024